| Reaction Details |
|---|
 | Report a problem with these data |
| Target | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
|---|
| Ligand | BDBM14390 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_877570 (CHEMBL2184505) |
|---|
| IC50 | 4690±n/a nM |
|---|
| Citation |  Wang, G; Liu, Z; Chen, T; Wang, Z; Yang, H; Zheng, M; Ren, J; Tian, G; Yang, X; Li, L; Li, J; Suo, J; Zhang, R; Jiang, X; Terrett, NK; Shen, J; Xu, Y; Jiang, H Design, synthesis, and pharmacological evaluation of monocyclic pyrimidinones as novel inhibitors of PDE5. J Med Chem55:10540-50 (2012) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
|---|
| Name: | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A |
|---|
| Synonyms: | 3',5'-cyclic phosphodiesterase | PDE7A | PDE7A_HUMAN | Phosphodiesterase 7 | Phosphodiesterase 7 (PDE7) | Phosphodiesterase 7A | Phosphodiesterase 7A (PDE7A1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55514.96 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q13946 |
|---|
| Residue: | 482 |
|---|
| Sequence: | MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
|
|
|
|---|
| BDBM14390 |
|---|
| n/a |
|---|
| Name | BDBM14390 |
|---|
| Synonyms: | 5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phenyl]-1-methyl-3-n-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one | 5-{2-ethoxy-5-[(4-methylpiperazine-1-)sulfonyl]phenyl}-1-methyl-3-propyl-1H,6H,7H-pyrazolo[4,3-d]pyrimidin-7-one | CHEMBL192 | SILDENAFIL CITRATE | Sildenafil | Sildenafil# | US11155558, Compound sildenafil | US11242347, Compound sildenafil | US11897890, Compound sildenafil | Viagra |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H30N6O4S |
|---|
| Mol. Mass. | 474.576 |
|---|
| SMILES | CCCc1nn(C)c2c1nc([nH]c2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCN(C)CC1 |
|---|
| Structure | 
|
|---|
Search and Browse
