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TargetHistone-lysine N-methyltransferase SUV39H2 (Suv39H2)
LigandBDBM50400778
Substrate/Competitorn/a
Meas. Tech.ChEMBL_879132
IC50 123000±n/a nM
Citation Verma SKTian XLaFrance LVDuquenne CSuarez DPNewlander KARomeril SPBurgess JLGrant SWBrackley JAGraves APScherzer DAShu AThompson COtt HMAller GSMachutta CADiaz EJiang YJohnson NWKnight SDKruger RGMcCabe MTDhanak DTummino PJCreasy CLMiller WH Identification of Potent, Selective, Cell-Active Inhibitors of the Histone Lysine Methyltransferase EZH2. ACS Med Chem Lett 3:1091-1096 (2012) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase SUV39H2 (Suv39H2)
Name:Histone-lysine N-methyltransferase SUV39H2 (Suv39H2)
Synonyms:H3-K9-HMTase 2 | Histone H3-K9 methyltransferase 2 | Histone-lysine N-methyltransferase SUV39H2 | Lysine N-methyltransferase 1B | Su(var)3-9 homolog 2 | Suppressor of variegation 3-9 homolog 2
Type:Enzyme
Mol. Mass.:46692.47
Organism:Homo sapiens (Human)
Description:Q9H5I1
Residue:410
Sequence:
MAAVGAEARGAWCVPCLVSLDTLQELCRKEKLTCKSIGITKRNLNNYEVEYLCDYKVVKD
MEYYLVKWKGWPDSTNTWEPLQNLKCPLLLQQFSNDKHNYLSQVKKGKAITPKDNNKTLK
PAIAEYIVKKAKQRIALQRWQDELNRRKNHKGMIFVENTVDLEGPPSDFYYINEYKPAPG
ISLVNEATFGCSCTDCFFQKCCPAEAGVLLAYNKNQQIKIPPGTPIYECNSRCQCGPDCP
NRIVQKGTQYSLCIFRTSNGRGWGVKTLVKIKRMSFVMEYVGEVITSEEAERRGQFYDNK
GITYLFDLDYESDEFTVDAARYGNVSHFVNHSCDPNLQVFNVFIDNLDTRLPRIALFSTR
TINAGEELTFDYQMKGSGDISSDSIDHSPAKKRVRTVCKCGAVTCRGYLN
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  Blast E-value cutoff:
BDBM50400778
n/a
NameBDBM50400778
Synonyms:CHEMBL2204995
TypeSmall organic molecule
Emp. Form.C31H39N7O2
Mol. Mass.541.6871
SMILESCCCc1cc(C)[nH]c(=O)c1CNC(=O)c1cc(cc2n(ncc12)C(C)C)-c1ccnc(c1)N1CCN(C)CC1
Structure
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