| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50217569 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_587795 (CHEMBL1043073) |
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| Ki | 7.08±n/a nM |
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| Citation |  Dvorak, CA; Apodaca, R; Xiao, W; Jablonowski, JA; Bonaventure, P; Dugovic, C; Shelton, J; Lord, B; Miller, K; Dvorak, LK; Lovenberg, TW; Carruthers, NI Diamine-based human histamine H3 receptor antagonists: (4-aminobutyn-1-yl)benzylamines. Eur J Med Chem44:4098-106 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | HH3R | HRH3_RAT | Hrh3 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48607.98 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 445 |
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| Sequence: | MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCAS
SVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAG
PEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAA
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSL
AIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFR
RAFTKLLCPQKLKVQPHGSLEQCWK
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| BDBM50217569 |
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| n/a |
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| Name | BDBM50217569 |
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| Synonyms: | 4-(3-(4-(piperidin-1-yl)but-1-ynyl)benzyl)morpholine | 4-[3-(4-Piperidin-1-yl-but-1-ynyl)-benzyl]-morpholine | CHEMBL237087 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H28N2O |
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| Mol. Mass. | 312.4491 |
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| SMILES | C(CN1CCCCC1)C#Cc1cccc(CN2CCOCC2)c1 |
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| Structure | 
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