| Reaction Details |
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 | Report a problem with these data |
| Target | Hexokinase-4 |
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| Ligand | BDBM50431770 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_951811 (CHEMBL2353001) |
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| EC50 | 3100±n/a nM |
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| Citation |  Cheruvallath, ZS; Gwaltney, SL; Sabat, M; Tang, M; Feng, J; Wang, H; Miura, J; Guntupalli, P; Jennings, A; Hosfield, D; Lee, B; Wu, Y Design, synthesis and SAR of novel glucokinase activators. Bioorg Med Chem Lett23:2166-71 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Hexokinase-4 |
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| Name: | Hexokinase-4 |
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| Synonyms: | GCK | Glucokinase (GCK) | Glucokinase (GK) | Glucokinase/Glucokinase regulatory protein | HK IV | HK4 | HXK4_HUMAN | Hexokinase-4 | Hexokinase-D |
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| Type: | Enzyme |
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| Mol. Mass.: | 52175.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P35557 |
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| Residue: | 465 |
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| Sequence: | MLDDRARMEAAKKEKVEQILAEFQLQEEDLKKVMRRMQKEMDRGLRLETHEEASVKMLPT
YVRSTPEGSEVGDFLSLDLGGTNFRVMLVKVGEGEEGQWSVKTKHQMYSIPEDAMTGTAE
MLFDYISECISDFLDKHQMKHKKLPLGFTFSFPVRHEDIDKGILLNWTKGFKASGAEGNN
VVGLLRDAIKRRGDFEMDVVAMVNDTVATMISCYYEDHQCEVGMIVGTGCNACYMEEMQN
VELVEGDEGRMCVNTEWGAFGDSGELDEFLLEYDRLVDESSANPGQQLYEKLIGGKYMGE
LVRLVLLRLVDENLLFHGEASEQLRTRGAFETRFVSQVESDTGDRKQIYNILSTLGLRPS
TTDCDIVRRACESVSTRAAHMCSAGLAGVINRMRESRSEDVMRITVGVDGSVYKLHPSFK
ERFHASVRRLTPSCEITFIESEEGSGRGAALVSAVACKKACMLGQ
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| BDBM50431770 |
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| n/a |
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| Name | BDBM50431770 |
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| Synonyms: | CHEMBL2346899 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21FN4O3S |
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| Mol. Mass. | 416.469 |
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| SMILES | Fc1ccc2[nH]c(=O)n([C@@H](CC3CCCCC3)C(=O)Nc3nccs3)c(=O)c2c1 |r| |
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| Structure | 
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