| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D6 |
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| Ligand | BDBM50443208 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1276540 (CHEMBL3088767) |
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| IC50 | 200±n/a nM |
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| Citation |  Chen, JJ; Qian, W; Biswas, K; Yuan, C; Amegadzie, A; Liu, Q; Nixey, T; Zhu, J; Ncube, M; Rzasa, RM; Chavez, F; Chen, N; DeMorin, F; Rumfelt, S; Tegley, CM; Allen, JR; Hitchcock, S; Hungate, R; Bartberger, MD; Zalameda, L; Liu, Y; McCarter, JD; Zhang, J; Zhu, L; Babu-Khan, S; Luo, Y; Bradley, J; Wen, PH; Reid, DL; Koegler, F; Dean, C; Hickman, D; Correll, TL; Williamson, T; Wood, S Discovery of 2-methylpyridine-based biaryl amides as¿-secretase modulators for the treatment of Alzheimer's disease. Bioorg Med Chem Lett23:6447-54 (2013) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D6 |
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| Name: | Cytochrome P450 2D6 |
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| Synonyms: | CP2D6_HUMAN | CYP2D6 | CYP2DL1 | CYPIID6 | Cytochrome P450 2D6 (CYP2D6) | Debrisoquine 4-hydroxylase | P450-DB1 |
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| Type: | Protein |
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| Mol. Mass.: | 55774.82 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10635 |
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| Residue: | 497 |
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| Sequence: | MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQ
LRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVF
LARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDK
AVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKV
LRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVA
DLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVI
HEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHF
LDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGV
FAFLVSPSPYELCAVPR
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| BDBM50443208 |
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| n/a |
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| Name | BDBM50443208 |
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| Synonyms: | CHEMBL3087355 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H12Cl2N2O2S |
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| Mol. Mass. | 379.26 |
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| SMILES | Clc1cc(Cl)cc(c1)S(=O)(=O)Nc1ccc(cc1)-c1ccncc1 |
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| Structure | 
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