Reaction Details | |||
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Target | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | ||
Ligand | BDBM50001576 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_1336031 (CHEMBL3240324) | ||
IC50 | 1.000000±n/a nM | ||
Citation | Li, Z; Wang, X; Eksterowicz, J; Gribble, MW; Alba, GQ; Ayres, M; Carlson, TJ; Chen, A; Chen, X; Cho, R; Connors, RV; DeGraffenreid, M; Deignan, JT; Duquette, J; Fan, P; Fisher, B; Fu, J; Huard, JN; Kaizerman, J; Keegan, KS; Li, C; Li, K; Li, Y; Liang, L; Liu, W; Lively, SE; Lo, MC; Ma, J; McMinn, DL; Mihalic, JT; Modi, K; Ngo, R; Pattabiraman, K; Piper, DE; Queva, C; Ragains, ML; Suchomel, J; Thibault, S; Walker, N; Wang, X; Wang, Z; Wanska, M; Wehn, PM; Weidner, MF; Zhang, AJ; Zhao, X; Kamb, A; Wickramasinghe, D; Dai, K; McGee, LR; Medina, JC Discovery of AMG 925, a FLT3 and CDK4 dual kinase inhibitor with preferential affinity for the activated state of FLT3. J Med Chem57:3430-49 (2014) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | |||
Name: | Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 | ||
Synonyms: | CDK4/CycD | CDK4/CycD1 | CDK4/Cyclin D1 | CDK4/D1 | Cyclin-Dependent Kinase 4 (CDK4) | Cyclin-dependent kinase 4 | Cyclin-dependent kinase 4/G1/S-specific cyclin D1 | Cyclin-dependent kinase 4/cyclin D1 | ||
Type: | Protein Complex | ||
Mol. Mass.: | n/a | ||
Description: | CDK4/D1 complexes were purified from insect cells co-infected with baculovirus vectors containing each of the components. | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Cyclin-dependent kinase 4 | ||
Synonyms: | CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3 | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 33731.96 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P11802 | ||
Residue: | 303 | ||
Sequence: |
| ||
Component 2 | |||
Name: | G1/S-specific cyclin-D1 | ||
Synonyms: | B-cell lymphoma 1 protein | BCL-1 | BCL-1 oncogene | BCL1 | CCND1 | CCND1_HUMAN | PRAD1 | PRAD1 oncogene | ||
Type: | Enzyme Subunit | ||
Mol. Mass.: | 33717.70 | ||
Organism: | Homo sapiens (Human) | ||
Description: | n/a | ||
Residue: | 295 | ||
Sequence: |
| ||
BDBM50001576 | |||
n/a | |||
Name | BDBM50001576 | ||
Synonyms: | CHEMBL3237711 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H35FN8 | ||
Mol. Mass. | 502.6295 | ||
SMILES | C[C@H]1CC[C@@H](CC1)n1c2cnccc2c2cnc(Nc3ccc(N4CCC(CC4)N(C)C)c(F)n3)nc12 |r,wU:4.7,wD:1.0,(48.6,-50.76,;48.13,-49.29,;49.17,-48.15,;48.7,-46.68,;47.19,-46.36,;46.16,-47.5,;46.63,-48.96,;46.72,-44.9,;47.63,-43.65,;49.16,-43.49,;49.79,-42.08,;48.88,-40.83,;47.35,-40.99,;46.73,-42.4,;45.26,-42.87,;43.91,-42.1,;42.58,-42.88,;42.6,-44.41,;41.27,-45.19,;41.25,-46.72,;42.56,-47.49,;42.55,-49.02,;41.22,-49.78,;41.2,-51.31,;39.86,-52.07,;39.84,-53.6,;41.17,-54.39,;42.51,-53.63,;42.53,-52.09,;41.15,-55.93,;39.8,-56.68,;42.47,-56.72,;39.9,-49,;38.55,-49.76,;39.91,-47.47,;43.93,-45.18,;45.25,-44.42,)| | ||
Structure |