| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-3 |
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| Ligand | BDBM50002744 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1339380 (CHEMBL3243714) |
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| IC50 | 61±n/a nM |
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| Citation |  Wu, L; Lu, M; Yan, Z; Tang, X; Sun, B; Liu, W; Zhou, H; Yang, C 1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorg Med Chem22:2416-26 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Caspase-3 |
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| Name: | Caspase-3 |
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| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
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| Type: | Hydrolase; heterotetramer of two heterodimers |
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| Mol. Mass.: | 31607.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 277 |
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| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
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| BDBM50002744 |
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| n/a |
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| Name | BDBM50002744 |
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| Synonyms: | CHEMBL3233642 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O4S2 |
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| Mol. Mass. | 432.516 |
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| SMILES | CN1CCN(CC1)S(=O)(=O)c1ccc(NC(=O)n2sc3ccccc3c2=O)cc1 |
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| Structure | 
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