| Reaction Details |
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 | Report a problem with these data |
| Target | Caspase-7 |
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| Ligand | BDBM50002365 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1339381 (CHEMBL3243715) |
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| IC50 | 76±n/a nM |
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| Citation |  Wu, L; Lu, M; Yan, Z; Tang, X; Sun, B; Liu, W; Zhou, H; Yang, C 1,2-benzisothiazol-3-one derivatives as a novel class of small-molecule caspase-3 inhibitors. Bioorg Med Chem22:2416-26 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Caspase-7 |
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| Name: | Caspase-7 |
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| Synonyms: | Apoptotic protease Mch-3 | CASP-7 | CASP7 | CASP7_HUMAN | CMH-1 | Caspase | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
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| Type: | Enzyme |
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| Mol. Mass.: | 34273.91 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P55210 |
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| Residue: | 303 |
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| Sequence: | MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQY
NMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQ
DLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKL
FFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSW
FVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELY
FSQ
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| BDBM50002365 |
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| n/a |
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| Name | BDBM50002365 |
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| Synonyms: | CHEMBL3233632 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H20N4O2S |
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| Mol. Mass. | 368.453 |
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| SMILES | CN1CCN(CC1)c1cccc(NC(=O)n2sc3ccccc3c2=O)c1 |
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| Structure | 
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