| Reaction Details |
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 | Report a problem with these data |
| Target | Oxysterols receptor LXR-alpha |
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| Ligand | BDBM50034782 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1441018 (CHEMBL3377014) |
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| EC50 | 65±n/a nM |
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| Citation |  Kick, E; Martin, R; Xie, Y; Flatt, B; Schweiger, E; Wang, TL; Busch, B; Nyman, M; Gu, XH; Yan, G; Wagner, B; Nanao, M; Nguyen, L; Stout, T; Plonowski, A; Schulman, I; Ostrowski, J; Kirchgessner, T; Wexler, R; Mohan, R Liver X receptor (LXR) partial agonists: biaryl pyrazoles and imidazoles displaying a preference for LXRß. Bioorg Med Chem Lett25:372-7 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Oxysterols receptor LXR-alpha |
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| Name: | Oxysterols receptor LXR-alpha |
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| Synonyms: | LXRA | Liver X Receptor alpha (LXR-alpha) | Liver X receptor alpha | Liver X receptor alpha (LXRA) | Liver X receptor alpha (NR1H3) | Liver X, LXR alpha | NR1H3 | NR1H3_HUMAN | Nuclear orphan receptor LXR-alpha | Nuclear receptor subfamily 1 group H member 3 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 50403.85 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q13133 |
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| Residue: | 447 |
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| Sequence: | MSLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEA
AEPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKG
FFRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLK
RQEEEQAHATSLPPRASSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPM
APDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLL
ETSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLI
AISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSV
HSEQVFALRLQDKKLPPLLSEIWDVHE
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| BDBM50034782 |
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| n/a |
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| Name | BDBM50034782 |
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| Synonyms: | CHEMBL3360968 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17ClN2O4S2 |
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| Mol. Mass. | 472.964 |
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| SMILES | COC(=O)c1cc(-c2ccc(s2)-c2cccc(c2)S(C)(=O)=O)n(n1)-c1ccccc1Cl |
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| Structure | 
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