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TargetCytochrome P450 2C8
LigandBDBM50035810
Substrate/Competitorn/a
Meas. Tech.ChEMBL_1441086 (CHEMBL3377608)
IC50>20000±n/a nM
Citation Duan, JJLu, ZJiang, BYang, BVDoweyko, LMNirschl, DSHaque, LELin, SBrown, GHynes, JTokarski, JSSack, JSKhan, JLippy, JSZhang, RFPitt, SShen, GPitts, WJCarter, PHBarrish, JCNadler, SGSalter-Cid, LMMcKinnon, MFura, ASchieven, GLWrobleski, ST Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors. Bioorg Med Chem Lett24:5721-6 (2014) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Cytochrome P450 2C8
Name:Cytochrome P450 2C8
Synonyms:CP2C8_HUMAN | CYP2C8 | CYPIIC8 | Cytochrome P450 2C8 (CYP2C8) | P450 IIC2 | P450 MP-12/MP-20 | P450 form 1 | S-mephenytoin 4-hydroxylase
Type:Protein
Mol. Mass.:55839.23
Organism:Homo sapiens (Human)
Description:P10632
Residue:490
Sequence:
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKV
YGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRW
KEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICS
VVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALT
RSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTE
TTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSD
LVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFK
KSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLP
PSYQICFIPV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50035810
n/a
NameBDBM50035810
Synonyms:CHEMBL3359927
TypeSmall organic molecule
Emp. Form.C14H17FN4O
Mol. Mass.276.3094
SMILESC[C@]1(F)CCC[C@H]1Nc1c(cnn2cccc12)C(N)=O |r|
Structure
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