| Reaction Details |
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 | Report a problem with these data |
| Target | Glucose-dependent insulinotropic receptor |
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| Ligand | BDBM50364559 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1447044 (CHEMBL3374950) |
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| EC50 | 421±n/a nM |
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| Citation |  Buzard, DJ; Kim, SH; Lehmann, J; Han, S; Calderon, I; Wong, A; Kawasaki, A; Narayanan, S; Bhat, R; Gharbaoui, T; Lopez, L; Yue, D; Whelan, K; Al-Shamma, H; Unett, DJ; Shu, HH; Tung, SF; Chang, S; Chuang, CF; Morgan, M; Sadeque, A; Chu, ZL; Leonard, JN; Jones, RM Discovery and optimization of 5-fluoro-4,6-dialkoxypyrimidine GPR119 agonists. Bioorg Med Chem Lett24:4332-5 (2014) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glucose-dependent insulinotropic receptor |
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| Name: | Glucose-dependent insulinotropic receptor |
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| Synonyms: | GP119_RAT | Gpr119 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51687.59 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1506411 |
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| Residue: | 468 |
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| Sequence: | MESSFSFGVILAVLTILIIAVNALVVVAMLLSIYKNDGVGLCFTLNLAVADTLIGVAISG
LVTDQLSSSAQHTQKTLCSLRMAFVTSSAAASVLTVMLIAFDRYLAIKQPLRYFQIMNGL
VAGGCIAGLWLISYLIGFLPLGVSIFQQTTYHGPCTFFAVFHPRFVLTLSCAGFFPAVLL
FVFFYCDMLKIASVHSQHIRKMEHAGAMVGACRPPRPVNDFKAVRTVSVLIGSFTLSWSP
FLITSIVQVACHKCCLYQVLEKYLWLLGVGNSLLNPLIYAYWQREVRQQLCHMALGLLAD
GSTQPQIETLKGKEERKKVGRKTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDACDTQTLY
TCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDAQTLYTCDTQTLYTCDAQTLYTCDA
QTLYTCDAQTLYTCDAQTLYTSSLVTGQTEQTPLKRANMSDPLRTCRG
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| BDBM50364559 |
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| n/a |
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| Name | BDBM50364559 |
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| Synonyms: | CHEMBL1951032 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H29N5O6S |
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| Mol. Mass. | 479.55 |
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| SMILES | COc1c(Nc2ccc(nc2C)S(C)(=O)=O)ncnc1OC1CCN(CC1)C(=O)OC(C)C |
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| Structure | 
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