Reaction Details |
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Target | LIM domain kinase 1 |
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Ligand | BDBM50072672 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1467118 (CHEMBL3411315) |
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IC50 | 250±n/a nM |
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Citation | Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J Med Chem58:1846-61 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 1 |
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Name: | LIM domain kinase 1 |
Synonyms: | LIM domain kinase 1 | LIMK-1 | LIMK1_RAT | Limk | Limk1 |
Type: | PROTEIN |
Mol. Mass.: | 72598.76 |
Organism: | Rattus norvegicus |
Description: | ChEMBL_109573 |
Residue: | 647 |
Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCSQSIYDGQYLQALNADWHADCFRCCECSTSLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEHITKGLVMVGGELKYHPECFICLACGNFIGD
GDTYTLVEHSKLYCGQCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASAHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHIGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDSLGHGPVSDPSPLASPVHTPSGQAGSSARQKPVLRSCSID
TSPGAGSLVSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENRNVVVADFG
LARLMIDEKGQSEDLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EQWLETLRMHLAGHLPLGPQLEQLERGFWETYRRGESSLPAHPEVPD
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BDBM50072672 |
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n/a |
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Name | BDBM50072672 |
Synonyms: | CHEMBL3410056 |
Type | Small organic molecule |
Emp. Form. | C24H23ClFN5O2 |
Mol. Mass. | 467.923 |
SMILES | COCCN(C(=O)Nc1ccc(cc1F)-c1ncnc2[nH]c(C)c(C)c12)c1ccc(Cl)cc1 |
Structure |
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