Reaction Details |
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Target | LIM domain kinase 1 |
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Ligand | BDBM50072729 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1467101 (CHEMBL3411298) |
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IC50 | 47±n/a nM |
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Citation | Yin, Y; Zheng, K; Eid, N; Howard, S; Jeong, JH; Yi, F; Guo, J; Park, CM; Bibian, M; Wu, W; Hernandez, P; Park, H; Wu, Y; Luo, JL; LoGrasso, PV; Feng, Y Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors. J Med Chem58:1846-61 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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LIM domain kinase 1 |
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Name: | LIM domain kinase 1 |
Synonyms: | LIMK | LIMK-1 | LIMK1 | LIMK1_HUMAN |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 72591.81 |
Organism: | Homo sapiens (Human) |
Description: | gi_4505001 |
Residue: | 647 |
Sequence: | MRLTLLCCTWREERMGEEGSELPVCASCGQRIYDGQYLQALNADWHADCFRCCDCSASLS
HQYYEKDGQLFCKKDYWARYGESCHGCSEQITKGLVMVAGELKYHPECFICLTCGTFIGD
GDTYTLVEHSKLYCGHCYYQTVVTPVIEQILPDSPGSHLPHTVTLVSIPASSHGKRGLSV
SIDPPHGPPGCGTEHSHTVRVQGVDPGCMSPDVKNSIHVGDRILEINGTPIRNVPLDEID
LLIQETSRLLQLTLEHDPHDTLGHGLGPETSPLSSPAYTPSGEAGSSARQKPVLRSCSID
RSPGAGSLGSPASQRKDLGRSESLRVVCRPHRIFRPSDLIHGEVLGKGCFGQAIKVTHRE
TGEVMVMKELIRFDEETQRTFLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGT
LRGIIKSMDSQYPWSQRVSFAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKNVVVADFG
LARLMVDEKTQPEGLRSLKKPDRKKRYTVVGNPYWMAPEMINGRSYDEKVDVFSFGIVLC
EIIGRVNADPDYLPRTMDFGLNVRGFLDRYCPPNCPPSFFPITVRCCDLDPEKRPSFVKL
EHWLETLRMHLAGHLPLGPQLEQLDRGFWETYRRGESGLPAHPEVPD
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BDBM50072729 |
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n/a |
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Name | BDBM50072729 |
Synonyms: | CHEMBL3410051 |
Type | Small organic molecule |
Emp. Form. | C25H28N6O2 |
Mol. Mass. | 444.5288 |
SMILES | COc1ccc(cc1)N(CCN(C)C)C(=O)Nc1ccc(cc1)-c1ncnc2[nH]cc(C)c12 |
Structure |
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