| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PAK 6 |
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| Ligand | BDBM101618 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513385 (CHEMBL3611425) |
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| IC50 | 17±n/a nM |
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| Citation |  Karpov, AS; Amiri, P; Bellamacina, C; Bellance, MH; Breitenstein, W; Daniel, D; Denay, R; Fabbro, D; Fernandez, C; Galuba, I; Guerro-Lagasse, S; Gutmann, S; Hinh, L; Jahnke, W; Klopp, J; Lai, A; Lindvall, MK; Ma, S; Möbitz, H; Pecchi, S; Rummel, G; Shoemaker, K; Trappe, J; Voliva, C; Cowan-Jacob, SW; Marzinzik, AL Optimization of a Dibenzodiazepine Hit to a Potent and Selective Allosteric PAK1 Inhibitor. ACS Med Chem Lett6:776-81 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase PAK 6 |
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| Name: | Serine/threonine-protein kinase PAK 6 |
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| Synonyms: | PAK5 | PAK6 | PAK6_HUMAN | Serine/threonine-protein kinase PAK5 | Serine/threonine-protein kinase PAK6 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 74897.61 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1513397 |
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| Residue: | 681 |
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| Sequence: | MFRKKKKKRPEISAPQNFQHRVHTSFDPKEGKFVGLPPQWQNILDTLRRPKPVVDPSRIT
RVQLQPMKTVVRGSAMPVDGYISGLLNDIQKLSVISSNTLRGRSPTSRRRAQSLGLLGDE
HWATDPDMYLQSPQSERTDPHGLYLSCNGGTPAGHKQMPWPEPQSPRVLPNGLAAKAQSL
GPAEFQGASQRCLQLGACLQSSPPGASPPTGTNRHGMKAAKHGSEEARPQSCLVGSATGR
PGGEGSPSPKTRESSLKRRLFRSMFLSTAATAPPSSSKPGPPPQSKPNSSFRPPQKDNPP
SLVAKAQSLPSDQPVGTFSPLTTSDTSSPQKSLRTAPATGQLPGRSSPAGSPRTWHAQIS
TSNLYLPQDPTVAKGALAGEDTGVVTHEQFKAALRMVVDQGDPRLLLDSYVKIGEGSTGI
VCLAREKHSGRQVAVKMMDLRKQQRRELLFNEVVIMRDYQHFNVVEMYKSYLVGEELWVL
MEFLQGGALTDIVSQVRLNEEQIATVCEAVLQALAYLHAQGVIHRDIKSDSILLTLDGRV
KLSDFGFCAQISKDVPKRKSLVGTPYWMAPEVISRSLYATEVDIWSLGIMVIEMVDGEPP
YFSDSPVQAMKRLRDSPPPKLKNSHKVSPVLRDFLERMLVRDPQERATAQELLDHPFLLQ
TGLPECLVPLIQLYRKQTSTC
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| BDBM101618 |
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| n/a |
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| Name | BDBM101618 |
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| Synonyms: | US8530652, 114 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H30N8OS |
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| Mol. Mass. | 490.624 |
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| SMILES | CN(C)C[C@@H](NC(=O)N1Cc2c(Nc3nc(C)nc4ccsc34)n[nH]c2C1(C)C)c1ccccc1 |
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| Structure | 
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