| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein phosphatase 5 |
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| Ligand | BDBM50112357 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1513413 (CHEMBL3611568) |
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| IC50 | >50000±n/a nM |
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| Citation |  He, R; Yu, ZH; Zhang, RY; Wu, L; Gunawan, AM; Lane, BS; Shim, JS; Zeng, LF; He, Y; Chen, L; Wells, CD; Liu, JO; Zhang, ZY Exploring the Existing Drug Space for Novel pTyr Mimetic and SHP2 Inhibitors. ACS Med Chem Lett6:782-6 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein phosphatase 5 |
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| Name: | Serine/threonine-protein phosphatase 5 |
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| Synonyms: | PP-T | PP5 | PPP5 | PPP5C | PPP5_HUMAN | PPT | Protein phosphatase 5 (PP5) | Protein phosphatase T | Serine/threonine-protein phosphatase 5 |
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| Type: | Enzyme |
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| Mol. Mass.: | 56875.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53041 |
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| Residue: | 499 |
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| Sequence: | MAMAEGERTECAEPPRDEPPADGALKRAEELKTQANDYFKAKDYENAIKFYSQAIELNPS
NAIYYGNRSLAYLRTECYGYALGDATRAIELDKKYIKGYYRRAASNMALGKFRAALRDYE
TVVKVKPHDKDAKMKYQECNKIVKQKAFERAIAGDEHKRSVVDSLDIESMTIEDEYSGPK
LEDGKVTISFMKELMQWYKDQKKLHRKCAYQILVQVKEVLSKLSTLVETTLKETEKITVC
GDTHGQFYDLLNIFELNGLPSETNPYIFNGDFVDRGSFSVEVILTLFGFKLLYPDHFHLL
RGNHETDNMNQIYGFEGEVKAKYTAQMYELFSEVFEWLPLAQCINGKVLIMHGGLFSEDG
VTLDDIRKIERNRQPPDSGPMCDLLWSDPQPQNGRSISKRGVSCQFGPDVTKAFLEENNL
DYIIRSHEVKAEGYEVAHGGRCVTVFSAPNYCDQMGNKASYIHLQGSDLRPQFHQFTAVP
HPNVKPMAYANTLLQLGMM
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| BDBM50112357 |
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| n/a |
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| Name | BDBM50112357 |
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| Synonyms: | CHEMBL3609375 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25N3O6S |
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| Mol. Mass. | 495.548 |
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| SMILES | CC(C)c1ccc(NC(=O)C(=O)Nc2ccc(NC(=O)C(c3ccccc3)S(O)(=O)=O)cc2)cc1 |
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| Structure | 
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