Reaction Details |
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Target | Cytochrome P450 26A1 |
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Ligand | BDBM50342128 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_1517856 (CHEMBL3620652) |
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IC50 | 3.0±n/a nM |
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Citation | Sun, B; Liu, K; Han, J; Zhao, LY; Su, X; Lin, B; Zhao, DM; Cheng, MS Design, synthesis, and biological evaluation of amide imidazole derivatives as novel metabolic enzyme CYP26A1 inhibitors. Bioorg Med Chem23:6763-73 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Cytochrome P450 26A1 |
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Name: | Cytochrome P450 26A1 |
Synonyms: | CP26A_HUMAN | CYP26 | CYP26A1 | Cytochrome CYP26A1 | Cytochrome P450 26A1 | Cytochrome P450 retinoic acid-inactivating 1 | P450RAI1 | Retinoic acid 4-hydroxylase |
Type: | Enzyme |
Mol. Mass.: | 56216.16 |
Organism: | Homo sapiens (Human) |
Description: | O43174 |
Residue: | 497 |
Sequence: | MGLPALLASALCTFVLPLLLFLAAIKLWDLYCVSGRDRSCALPLPPGTMGFPFFGETLQM
VLQRRKFLQMKRRKYGFIYKTHLFGRPTVRVMGADNVRRILLGEHRLVSVHWPASVRTIL
GSGCLSNLHDSSHKQRKKVIMRAFSREALECYVPVITEEVGSSLEQWLSCGERGLLVYPE
VKRLMFRIAMRILLGCEPQLAGDGDSEQQLVEAFEEMTRNLFSLPIDVPFSGLYRGMKAR
NLIHARIEQNIRAKICGLRASEAGQGCKDALQLLIEHSWERGERLDMQALKQSSTELLFG
GHETTASAATSLITYLGLYPHVLQKVREELKSKGLLCKSNQDNKLDMEILEQLKYIGCVI
KETLRLNPPVPGGFRVALKTFELNGYQIPKGWNVIYSICDTHDVAEIFTNKEEFNPDRFM
LPHPEDASRFSFIPFGGGLRSCVGKEFAKILLKIFTVELARHCDWQLLNGPPTMKTSPTV
YPVDNLPARFTHFHGEI
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BDBM50342128 |
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n/a |
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Name | BDBM50342128 |
Synonyms: | 3-Imidazol-1-yl-2-methyl-3-[4-(naphthalen-2-ylamino)-phenyl]-propionicAcid Methyl Ester | CHEMBL1766005 |
Type | Small organic molecule |
Emp. Form. | C25H25N3O2 |
Mol. Mass. | 399.4849 |
SMILES | COC(=O)C(C)(C)C(c1ccc(Nc2ccc3ccccc3c2)cc1)n1ccnc1 |
Structure |
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