| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M1 |
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| Ligand | BDBM50135217 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1545717 (CHEMBL3748814) |
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| EC50 | 9.0±n/a nM |
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| Citation |  Davoren, JE; O'Neil, SV; Anderson, DP; Brodney, MA; Chenard, L; Dlugolenski, K; Edgerton, JR; Green, M; Garnsey, M; Grimwood, S; Harris, AR; Kauffman, GW; LaChapelle, E; Lazzaro, JT; Lee, CW; Lotarski, SM; Nason, DM; Obach, RS; Reinhart, V; Salomon-Ferrer, R; Steyn, SJ; Webb, D; Yan, J; Zhang, L Design and optimization of selective azaindole amide M1 positive allosteric modulators. Bioorg Med Chem Lett26:650-5 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M1 |
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| Name: | Muscarinic acetylcholine receptor M1 |
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| Synonyms: | ACM1_HUMAN | CHRM1 | Cholinergic receptor, muscarinic 1 | Cholinergic, muscarinic M1 |
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| Type: | Protein |
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| Mol. Mass.: | 51442.54 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P11229 |
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| Residue: | 460 |
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| Sequence: | MNTSAPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVN
NYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLIS
FDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYI
QFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSS
SERSQPGAEGSPETPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEV
VIKMPMVDPEAQAPTKQPPRSSPNTVKRPTKKGRDRAGKGQKPRGKEQLAKRKTFSLVKE
KKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTINPMCYAL
CNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQC
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| BDBM50135217 |
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| n/a |
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| Name | BDBM50135217 |
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| Synonyms: | CHEMBL3746869 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H27N5O3 |
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| Mol. Mass. | 445.5136 |
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| SMILES | Cc1ccnc2c(cn(Cc3ccc(cc3)-c3ccn(C)n3)c12)C(=O)N[C@H]1CCOC[C@@H]1O |r| |
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| Structure | 
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