| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Coagulation factor IX |
|---|
| Ligand | BDBM50136579 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_1548358 (CHEMBL3756142) |
|---|
| Ki | >73000±n/a nM |
|---|
| Citation |  Smith, LM; Orwat, MJ; Hu, Z; Han, W; Wang, C; Rossi, KA; Gilligan, PJ; Pabbisetty, KB; Osuna, H; Corte, JR; Rendina, AR; Luettgen, JM; Wong, PC; Narayanan, R; Harper, TW; Bozarth, JM; Crain, EJ; Wei, A; Ramamurthy, V; Morin, PE; Xin, B; Zheng, J; Seiffert, DA; Quan, ML; Lam, PY; Wexler, RR; Pinto, DJ Novel phenylalanine derived diamides as Factor XIa inhibitors. Bioorg Med Chem Lett26:472-8 (2016) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Coagulation factor IX |
|---|
| Name: | Coagulation factor IX |
|---|
| Synonyms: | Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 51768.83 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P00740 |
|---|
| Residue: | 461 |
|---|
| Sequence: | MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNL
ERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCP
FGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGR
VSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPW
QVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRII
PHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVF
HKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVE
GTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
|
|
|
|---|
| BDBM50136579 |
|---|
| n/a |
|---|
| Name | BDBM50136579 |
|---|
| Synonyms: | CHEMBL3754781 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C28H24ClN7O4 |
|---|
| Mol. Mass. | 557.988 |
|---|
| SMILES | Oc1cc(=O)[nH]c2ccc(cc12)C(=O)N[C@@H](Cc1ccccc1)C(=O)NCCc1cc(Cl)ccc1-n1cnnn1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
