| Reaction Details |
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 | Report a problem with these data |
| Target | Muscarinic acetylcholine receptor M4 |
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| Ligand | BDBM50174731 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1579485 (CHEMBL3810554) |
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| EC50 | 603±n/a nM |
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| Citation |  Wood, MR; Noetzel, MJ; Engers, JL; Bollinger, KA; Melancon, BJ; Tarr, JC; Han, C; West, M; Gregro, AR; Lamsal, A; Chang, S; Ajmera, S; Smith, E; Chase, P; Hodder, PS; Bubser, M; Jones, CK; Hopkins, CR; Emmitte, KA; Niswender, CM; Wood, MW; Duggan, ME; Conn, PJ; Bridges, TM; Lindsley, CW Discovery and optimization of a novel series of highly CNS penetrant M4 PAMs based on a 5,6-dimethyl-4-(piperidin-1-yl)thieno[2,3-d]pyrimidine core. Bioorg Med Chem Lett26:3029-33 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Muscarinic acetylcholine receptor M4 |
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| Name: | Muscarinic acetylcholine receptor M4 |
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| Synonyms: | ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 53079.31 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173 |
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| Residue: | 479 |
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| Sequence: | MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVN
RQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASV
MNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTV
PDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAK
TLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGS
ATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIV
PATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMV
LVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
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| BDBM50174731 |
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| n/a |
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| Name | BDBM50174731 |
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| Synonyms: | CHEMBL3809096 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H22N4OS |
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| Mol. Mass. | 354.469 |
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| SMILES | Cc1sc2ncnc(N3CCC(CC3)Oc3ccc(C)nc3)c2c1C |
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| Structure | 
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