| Reaction Details |
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 | Report a problem with these data |
| Target | Nuclear receptor ROR-alpha |
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| Ligand | BDBM50177015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_1582650 (CHEMBL3817091) |
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| IC50 | >10000±n/a nM |
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| Citation |  Zheng, Y; Zhuang, L; Fan, KY; Tice, CM; Zhao, W; Dong, C; Lotesta, SD; Leftheris, K; Lindblom, PR; Liu, Z; Shimada, J; Noto, PB; Meng, S; Hardy, A; Howard, L; Krosky, P; Guo, J; Lipinski, K; Kandpal, G; Bukhtiyarov, Y; Zhao, Y; Lala, D; Van Orden, R; Zhou, J; Chen, G; Wu, Z; McKeever, BM; McGeehan, GM; Gregg, RE; Claremon, DA; Singh, SB Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR)ß Agonist. J Med Chem59:3264-71 (2016) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Nuclear receptor ROR-alpha |
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| Name: | Nuclear receptor ROR-alpha |
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| Synonyms: | NR1F1 | Nuclear receptor RZR-alpha | Nuclear receptor subfamily 1 group F member 1 | RAR-related orphan receptor A | RORA | RORA_HUMAN | RZRA | Retinoid-related orphan receptor-alpha |
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| Type: | PROTEIN |
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| Mol. Mass.: | 58976.26 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_101591 |
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| Residue: | 523 |
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| Sequence: | MESAPAAPDPAASEPGSSGADAAAGSRETPLNQESARKSEPPAPVRRQSYSSTSRGISVT
KKTHTSQIEIIPCKICGDKSSGIHYGVITCEGCKGFFRRSQQSNATYSCPRQKNCLIDRT
SRNRCQHCRLQKCLAVGMSRDAVKFGRMSKKQRDSLYAEVQKHRMQQQQRDHQQQPGEAE
PLTPTYNISANGLTELHDDLSNYIDGHTPEGSKADSAVSSFYLDIQPSPDQSGLDINGIK
PEPICDYTPASGFFPYCSFTNGETSPTVSMAELEHLAQNISKSHLETCQYLREELQQITW
QTFLQEEIENYQNKQREVMWQLCAIKITEAIQYVVEFAKRIDGFMELCQNDQIVLLKAGS
LEVVFIRMCRAFDSQNNTVYFDGKYASPDVFKSLGCEDFISFVFEFGKSLCSMHLTEDEI
ALFSAFVLMSADRSWLQEKVKIEKLQQKIQLALQHVLQKNHREDGILTKLICKVSTLRAL
CGRHTEKLMAFKAIYPDIVRLHFPPLYKELFTSEFEPAMQIDG
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| BDBM50177015 |
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| n/a |
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| Name | BDBM50177015 |
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| Synonyms: | CHEMBL3814206 | US10144715, Compound 19-1 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H27F3N4O4S |
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| Mol. Mass. | 488.524 |
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| SMILES | CC(C)[C@@H]1CN(CCN1c1ncc(CO)c(n1)C(F)(F)F)c1ccc(CO)c(c1)S(C)(=O)=O |r| |
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| Structure | 
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