| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase 1 |
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| Ligand | BDBM275404 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IMAP-FP Assay |
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| IC50 | 0.32±n/a nM |
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| Citation |  Siliphaivanh, P; Methot, J; Lipford, KA; Molinari, D; Sloman, DL; Witter, D; Zhou, H; Boyce, C; Huang, X; Lim, J; Guerin, D; Karunakaran, GB; Bakshi, RK; Liu, Z; Fu, J; Wan, Z; Liu, W ERK inhibitors US Patent US9884048 Publication Date 2/6/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Mitogen-activated protein kinase 1 |
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| Name: | Mitogen-activated protein kinase 1 |
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| Synonyms: | ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK |
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| Type: | Ser/Thr Protein Kinase |
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| Mol. Mass.: | 41392.76 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P28482 |
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| Residue: | 360 |
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| Sequence: | MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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| BDBM275404 |
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| n/a |
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| Name | BDBM275404 |
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| Synonyms: | 1-[(3R)-1-(2,6- difluorobenzyl)pyrrolidin-3- yl]-3-[1-(2-methylpyridin-4- yl)-1H-pyrazolo[3,4-c]pyridin- 5-yl]urea | US9884048, Example 283 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H23F2N7O |
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| Mol. Mass. | 463.4825 |
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| SMILES | Cc1cc(ccn1)-n1ncc2cc(NC(=O)N[C@@H]3CCN(Cc4c(F)cccc4F)C3)ncc12 |r| |
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| Structure | 
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