| Reaction Details |
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 | Report a problem with these data |
| Target | Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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| Ligand | BDBM220342 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ThermoFluor® Assay |
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| pH | 7±n/a |
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| Temperature | 274.15±n/a K |
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| Kd | 0.04±n/a nM |
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| Comments | extracted |
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| Citation |  Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Pierce, J; Goldberg, S; Fourie, A; Xue, X Methylene linked quinolinyl modulators of RORγt US Patent US9290476 Publication Date 3/22/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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| Name: | Isoform 2 of Nuclear receptor ROR-gamma (RORgT) |
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| Synonyms: | Isoform 2 of Nuclear receptor ROR-gamma | NR1F3 | Nuclear receptor ROR-gamma (RORgT) | Nuclear receptor ROR-gammaT | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma (RORgT) | Retinoid-related orphan receptor-gamma (RORĪ³T) |
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| Type: | Protein |
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| Mol. Mass.: | 55831.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P51449-2 |
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| Residue: | 497 |
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| Sequence: | MRTQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRN
RCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGA
QGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCH
LEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPE
APYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCA
HHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGK
YGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQ
LQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPL
YKELFSTETESPVGLSK
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| BDBM220342 |
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| n/a |
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| Name | BDBM220342 |
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| Synonyms: | US9290476, 88B | US9290476, 88C |
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| Type | Small organic molecule |
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| Emp. Form. | C30H22F3N7O |
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| Mol. Mass. | 553.5372 |
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| SMILES | Cc1ccc(c(C)n1)C(O)(c1cnnn1C)c1ccc2nc(C#N)c(Cc3ccc(cc3)C(F)(F)F)c(C#N)c2c1 |
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| Structure | 
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