Reaction Details |
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Target | Nuclear receptor ROR-gamma [258-518] |
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Ligand | BDBM221232 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ThermoFluor® Assay |
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pH | 7±n/a |
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Temperature | 274.15±n/a K |
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Kd | 51±n/a nM |
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Comments | extracted |
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Citation | Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Heteroaryl linked quinolinyl modulators of RORγt US Patent US9303015 Publication Date 4/5/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma [258-518] |
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Name: | Nuclear receptor ROR-gamma [258-518] |
Synonyms: | NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORgammat) |
Type: | Enzyme |
Mol. Mass.: | 30146.98 |
Organism: | Homo sapiens (Human) |
Description: | Artificial Sequence Construct used in the Thermofluor Assay (Seq No: 4) |
Residue: | 261 |
Sequence: | STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVF
FEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKR
KVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA
FPPLYKELFSTETESPVGLSK
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BDBM221232 |
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n/a |
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Name | BDBM221232 |
Synonyms: | US9303015, 6a | US9303015, 6b | US9303015, 6c |
Type | Small organic molecule |
Emp. Form. | C30H27ClF3N5O2 |
Mol. Mass. | 582.016 |
SMILES | CCN(CC)c1nc2ccc(cc2c(Cl)c1Oc1ccccc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F |
Structure |
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