Reaction Details |
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Target | Nuclear receptor ROR-gamma [258-518,Y502F] |
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Ligand | BDBM221240 |
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Substrate/Competitor | n/a |
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Meas. Tech. | RORγt Reporter Assay |
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IC50 | 6000±n/a nM |
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Citation | Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Heteroaryl linked quinolinyl modulators of RORγt US Patent US9303015 Publication Date 4/5/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma [258-518,Y502F] |
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Name: | Nuclear receptor ROR-gamma [258-518,Y502F] |
Synonyms: | NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORgammat) |
Type: | Enzyme |
Mol. Mass.: | 30130.98 |
Organism: | Homo sapiens (Human) |
Description: | Artificial LBD sequence mutated AF2 domain (Seq No: 9) |
Residue: | 261 |
Sequence: | STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVF
FEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKR
KVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA
FPPLFKELFSTETESPVGLSK
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BDBM221240 |
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n/a |
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Name | BDBM221240 |
Synonyms: | US9303015, 14a | US9303015, 14b | US9303015, 14c |
Type | Small organic molecule |
Emp. Form. | C28H21ClF4N4O3 |
Mol. Mass. | 572.938 |
SMILES | CCOc1nc2ccc(cc2c(Cl)c1Oc1ccc(F)cc1)C(O)(c1cncn1C)c1ccc(nc1)C(F)(F)F |
Structure |
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