Reaction Details |
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Target | Nuclear receptor ROR-gamma [258-518,Y502F] |
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Ligand | BDBM221249 |
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Substrate/Competitor | n/a |
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Meas. Tech. | RORγt Reporter Assay |
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IC50 | 700±n/a nM |
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Citation | Leonard, KA; Barbay, K; Edwards, JP; Kreutter, KD; Kummer, DA; Maharoof, U; Nishimura, R; Urbanski, M; Venkatesan, H; Wang, A; Wolin, RL; Woods, CR; Fourie, A; Xue, X Heteroaryl linked quinolinyl modulators of RORγt US Patent US9303015 Publication Date 4/5/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Nuclear receptor ROR-gamma [258-518,Y502F] |
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Name: | Nuclear receptor ROR-gamma [258-518,Y502F] |
Synonyms: | NR1F3 | RORC | RORG | RORG_HUMAN | RZRG | Retinoic acid-related nuclear receptor gamma t (RORgammat) |
Type: | Enzyme |
Mol. Mass.: | 30130.98 |
Organism: | Homo sapiens (Human) |
Description: | Artificial LBD sequence mutated AF2 domain (Seq No: 9) |
Residue: | 261 |
Sequence: | STPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMW
ERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVF
FEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKR
KVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAA
FPPLFKELFSTETESPVGLSK
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BDBM221249 |
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n/a |
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Name | BDBM221249 |
Synonyms: | US9303015, 23 |
Type | Small organic molecule |
Emp. Form. | C27H17Cl2FN4O2 |
Mol. Mass. | 519.354 |
SMILES | Cn1cncc1C(O)(c1ccc(Cl)cc1)c1ccc2nc(C#N)c(Oc3ccc(F)cc3)c(Cl)c2c1 |
Structure |
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