Found 119 hits of affinity data for UniProtKB/TrEMBL: O88867 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061916
(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 4.80 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibitory constant of the compound against Kynurenine 3-hydroxylase |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50266003
(CHEMBL4091152)Show SMILES C[C@@H](Oc1cc2onc(CCC(O)=O)c2cc1Cl)c1ccccn1 |r| Show InChI InChI=1S/C17H15ClN2O4/c1-10(13-4-2-3-7-19-13)23-16-9-15-11(8-12(16)18)14(20-24-15)5-6-17(21)22/h2-4,7-10H,5-6H2,1H3,(H,21,22)/t10-/m1/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| PC cid PC sid PDB UniChem
| Article PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of rat KMO expressed in HEK293 cells using kynurenine as substrate measured after 20 hrs by LC-MS/MS analysis |
J Med Chem 60: 3383-3404 (2017)
Article DOI: 10.1021/acs.jmedchem.7b00055 BindingDB Entry DOI: 10.7270/Q26112SB |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061915
(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)Show InChI InChI=1S/C10H9Cl2NO3/c11-6-2-1-5(3-7(6)12)9(14)4-8(13)10(15)16/h1-3,8H,4,13H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| 95 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibitory constant of the compound against Kynurenine 3-hydroxylase |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072080
(CHEMBL3407919)Show InChI InChI=1S/C12H6ClF3N2O3/c13-7-3-6(1-2-10(7)21-12(14,15)16)8-4-9(11(19)20)18-5-17-8/h1-5H,(H,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat KMO assessed as conversion of kynurenine to 3-hydroxykynurenine by LC-MS/MS analysis |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061924
(4-Amino-N-[4-(2-fluoro-5-trifluoromethyl-phenyl)-t...)Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C16H11F4N3O2S2/c17-13-6-1-9(16(18,19)20)7-12(13)14-8-26-15(22-14)23-27(24,25)11-4-2-10(21)3-5-11/h1-8H,21H2,(H,22,23) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072083
(CHEMBL3407929)Show SMILES OC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 mins |
Bioorg Med Chem Lett 27: 2023-2028 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.078 BindingDB Entry DOI: 10.7270/Q23R0W54 |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072083
(CHEMBL3407929)Show SMILES OC(=O)[C@H]1C[C@@H]1C(=O)c1ccc(Cl)c(Cl)c1 |r| Show InChI InChI=1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16)/t6-,7-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 mins |
Bioorg Med Chem Lett 27: 2023-2028 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.078 BindingDB Entry DOI: 10.7270/Q23R0W54 |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50126147
(CHEMBL3629571)Show InChI InChI=1S/C11H8Cl2O3/c12-8-2-1-5(3-9(8)13)10(14)6-4-7(6)11(15)16/h1-3,6-7H,4H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
TES Pharma S.r.l.
Curated by ChEMBL
| Assay Description Inhibition of rat liver KMO using [3,5-3H]-kynurenine substrate |
J Med Chem 61: 745-759 (2018)
Article DOI: 10.1021/acs.jmedchem.7b01254 BindingDB Entry DOI: 10.7270/Q22J6F80 |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061916
(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
CHDI Management/CHDI Foundation
Curated by ChEMBL
| Assay Description Inhibition of Wistar rat KMO assessed as 3-hydroxykynurenine formation preincubated for 5 mins using 100 uM kynurenine as substrate by LC-MS/MS analy... |
Drug Metab Dispos 40: 2297-306 (2012)
Article DOI: 10.1124/dmd.112.046532 BindingDB Entry DOI: 10.7270/Q2WW7KDQ |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061916
(3,4-Dimethoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-...)Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C17H15N3O6S2/c1-25-15-7-6-13(9-16(15)26-2)28(23,24)19-17-18-14(10-27-17)11-4-3-5-12(8-11)20(21)22/h3-10H,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061922
(CHEMBL140071 | N-[4-(2-Fluoro-5-trifluoromethyl-ph...)Show SMILES COc1ccc(cc1OC)S(=O)(=O)Nc1nc(cs1)-c1cc(ccc1F)C(F)(F)F Show InChI InChI=1S/C18H14F4N2O4S2/c1-27-15-6-4-11(8-16(15)28-2)30(25,26)24-17-23-14(9-29-17)12-7-10(18(20,21)22)3-5-13(12)19/h3-9H,1-2H3,(H,23,24) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 39 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061911
(4-Amino-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benzen...)Show SMILES Nc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C15H12N4O4S2/c16-11-4-6-13(7-5-11)25(22,23)18-15-17-14(9-24-15)10-2-1-3-12(8-10)19(20)21/h1-9H,16H2,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061906
(4-Methyl-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benze...)Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C16H13N3O4S2/c1-11-5-7-14(8-6-11)25(22,23)18-16-17-15(10-24-16)12-3-2-4-13(9-12)19(20)21/h2-10H,1H3,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 48 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061917
(4-Methoxy-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benz...)Show SMILES COc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1cccc(c1)[N+]([O-])=O Show InChI InChI=1S/C16H13N3O5S2/c1-24-13-5-7-14(8-6-13)26(22,23)18-16-17-15(10-25-16)11-3-2-4-12(9-11)19(20)21/h2-10H,1H3,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 51 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061918
(CHEMBL136265 | N-[4-(3,4-Dichloro-phenyl)-thiazol-...)Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1ccc(Cl)c(Cl)c1 Show InChI InChI=1S/C16H12Cl2N2O2S2/c1-10-2-5-12(6-3-10)24(21,22)20-16-19-15(9-23-16)11-4-7-13(17)14(18)8-11/h2-9H,1H3,(H,19,20) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061923
(CHEMBL335326 | N-[4-(4-Chloro-phenyl)-thiazol-2-yl...)Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1ccc(Cl)cc1 Show InChI InChI=1S/C16H13ClN2O2S2/c1-11-2-8-14(9-3-11)23(20,21)19-16-18-15(10-22-16)12-4-6-13(17)7-5-12/h2-10H,1H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 56 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072081
(CHEMBL3407922)Show InChI InChI=1S/C14H11ClN2O3/c15-10-5-8(1-4-13(10)20-9-2-3-9)11-6-12(14(18)19)17-7-16-11/h1,4-7,9H,2-3H2,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 72 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061909
(4-Methyl-N-(4-p-tolyl-thiazol-2-yl)-benzenesulfona...)Show InChI InChI=1S/C17H16N2O2S2/c1-12-3-7-14(8-4-12)16-11-22-17(18-16)19-23(20,21)15-9-5-13(2)6-10-15/h3-11H,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 76 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061913
(4-Chloro-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-benze...)Show SMILES [O-][N+](=O)c1cccc(c1)-c1csc(NS(=O)(=O)c2ccc(Cl)cc2)n1 Show InChI InChI=1S/C15H10ClN3O4S2/c16-11-4-6-13(7-5-11)25(22,23)18-15-17-14(9-24-15)10-2-1-3-12(8-10)19(20)21/h1-9H,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 84 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072078
(CHEMBL3407905)Show InChI InChI=1S/C11H6F2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 86 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072079
(CHEMBL3407913)Show InChI InChI=1S/C12H9ClN2O2/c1-7-2-3-8(4-9(7)13)10-5-11(12(16)17)15-6-14-10/h2-6H,1H3,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072077
(CHEMBL3407866)Show InChI InChI=1S/C11H6Cl2N2O2/c12-7-2-1-6(3-8(7)13)9-4-10(11(16)17)15-5-14-9/h1-5H,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 105 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat microglia cells |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061910
(CHEMBL138010 | N-[4-(4-Hydroxy-3-methyl-phenyl)-th...)Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1nc(cs1)-c1ccc(O)c(C)c1 Show InChI InChI=1S/C17H16N2O3S2/c1-11-3-6-14(7-4-11)24(21,22)19-17-18-15(10-23-17)13-5-8-16(20)12(2)9-13/h3-10,20H,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 114 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072244
((Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-...)Show InChI InChI=1S/C10H6F2O4/c11-6-2-1-5(3-7(6)12)8(13)4-9(14)10(15)16/h1-3H,4H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver |
J Med Chem 43: 123-7 (2000)
BindingDB Entry DOI: 10.7270/Q2RX9B9B |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061925
(3,4-Dichloro-N-[4-(3-nitro-phenyl)-thiazol-2-yl]-b...)Show SMILES [O-][N+](=O)c1cccc(c1)-c1csc(NS(=O)(=O)c2ccc(Cl)c(Cl)c2)n1 Show InChI InChI=1S/C15H9Cl2N3O4S2/c16-12-5-4-11(7-13(12)17)26(23,24)19-15-18-14(8-25-15)9-2-1-3-10(6-9)20(21)22/h1-8H,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072257
(2-Benzyl-4-(3,4-dichloro-phenyl)-4-oxo-butyric aci...)Show InChI InChI=1S/C17H14Cl2O3/c18-14-7-6-12(9-15(14)19)16(20)10-13(17(21)22)8-11-4-2-1-3-5-11/h1-7,9,13H,8,10H2,(H,21,22) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 180 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Inhibition of rat brain KYN 3-OHase. |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061915
(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)Show InChI InChI=1S/C10H9Cl2NO3/c11-6-2-1-5(3-7(6)12)9(14)4-8(13)10(15)16/h1-3,8H,4,13H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Evotec (U.K.) Ltd
Curated by ChEMBL
| Assay Description Inhibition of rat KMO |
J Med Chem 58: 1159-83 (2015)
Article DOI: 10.1021/jm501350y BindingDB Entry DOI: 10.7270/Q2445P5N |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061915
(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)Show InChI InChI=1S/C10H9Cl2NO3/c11-6-2-1-5(3-7(6)12)9(14)4-8(13)10(15)16/h1-3,8H,4,13H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Inhibition of rat liver KYN 3-OHase. |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061912
(CHEMBL343363 | N-[4-(3-Nitro-phenyl)-thiazol-2-yl]...)Show SMILES [O-][N+](=O)c1cccc(c1)-c1csc(NS(=O)(=O)c2ccccc2)n1 Show InChI InChI=1S/C15H11N3O4S2/c19-18(20)12-6-4-5-11(9-12)14-10-23-15(16-14)17-24(21,22)13-7-2-1-3-8-13/h1-10H,(H,16,17) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061915
(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)Show InChI InChI=1S/C10H9Cl2NO3/c11-6-2-1-5(3-7(6)12)9(14)4-8(13)10(15)16/h1-3,8H,4,13H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 237 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061914
(CHEMBL342434 | N-[4-(4-Methoxy-phenyl)-thiazol-2-y...)Show SMILES COc1ccc(cc1)-c1csc(NS(=O)(=O)c2ccc(C)cc2)n1 Show InChI InChI=1S/C17H16N2O3S2/c1-12-3-9-15(10-4-12)24(20,21)19-17-18-16(11-23-17)13-5-7-14(22-2)8-6-13/h3-11H,1-2H3,(H,18,19) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 240 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50083948
(4-(3-Chloro-4-fluoro-phenyl)-2-hydroxy-4-oxo-but-2...)Show InChI InChI=1S/C10H6ClFO4/c11-6-3-5(1-2-7(6)12)8(13)4-9(14)10(15)16/h1-3H,4H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 270 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver |
J Med Chem 43: 123-7 (2000)
BindingDB Entry DOI: 10.7270/Q2RX9B9B |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072242
(4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyric ac...)Show InChI InChI=1S/C10H8Cl2O4/c11-6-2-1-5(3-7(6)12)8(13)4-9(14)10(15)16/h1-3,9,14H,4H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 300 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of rat brain KYN 3-OHase |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50083940
(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)Show InChI InChI=1S/C10H7ClO4/c11-7-3-1-2-6(4-7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 320 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver |
J Med Chem 43: 123-7 (2000)
BindingDB Entry DOI: 10.7270/Q2RX9B9B |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061915
(2-Amino-4-(3,4-dichloro-phenyl)-4-oxo-butyric acid...)Show InChI InChI=1S/C10H9Cl2NO3/c11-6-2-1-5(3-7(6)12)9(14)4-8(13)10(15)16/h1-3,8H,4,13H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 330 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Compound was evaluated for the inhibition of rat liver KYN 3-OHase |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072248
((S)-4-(3,4-Dichloro-phenyl)-2-hydroxy-4-oxo-butyri...)Show InChI InChI=1S/C10H8Cl2O4/c11-6-2-1-5(3-7(6)12)8(13)4-9(14)10(15)16/h1-3,9,14H,4H2,(H,15,16)/t9-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL KEGG PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 420 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Inhibition of rat liver KYN 3-OHase. |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072244
((Z)-4-(3,4-Difluoro-phenyl)-2-hydroxy-4-oxo-but-2-...)Show InChI InChI=1S/C10H6F2O4/c11-6-2-1-5(3-7(6)12)8(13)4-9(14)10(15)16/h1-3H,4H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 440 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Inhibition of rat brain KYN 3-OHase. |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061921
(4-Methyl-N-(4-phenyl-thiazol-2-yl)-benzenesulfonam...)Show InChI InChI=1S/C16H14N2O2S2/c1-12-7-9-14(10-8-12)22(19,20)18-16-17-15(11-21-16)13-5-3-2-4-6-13/h2-11H,1H3,(H,17,18) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 470 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072249
(4-(3-Chloro-phenyl)-2-hydroxy-4-oxo-butyric acid |...)Show InChI InChI=1S/C10H9ClO4/c11-7-3-1-2-6(4-7)8(12)5-9(13)10(14)15/h1-4,9,13H,5H2,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 480 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Inhibition of rat brain KYN 3-OHase. |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50083950
((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...)Show SMILES N[C@@H](CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O Show InChI InChI=1S/C10H10N2O5/c11-8(10(14)15)5-9(13)6-2-1-3-7(4-6)12(16)17/h1-4,8H,5,11H2,(H,14,15)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested for inhibitory activity against kynurenine 3-hydroxylase |
Bioorg Med Chem Lett 5: 1451-1454 (1995)
Article DOI: 10.1016/0960-894X(95)00255-R BindingDB Entry DOI: 10.7270/Q2PR7VZZ |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50083931
(4-(3-Fluoro-phenyl)-2-hydroxy-4-oxo-but-2-enoic ac...)Show InChI InChI=1S/C10H7FO4/c11-7-3-1-2-6(4-7)8(12)5-9(13)10(14)15/h1-4H,5H2,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL KEGG PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 580 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver |
J Med Chem 43: 123-7 (2000)
BindingDB Entry DOI: 10.7270/Q2RX9B9B |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50061907
((+/-)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric aci...)Show InChI InChI=1S/C10H10N2O5/c11-8(10(14)15)5-9(13)6-2-1-3-7(4-6)12(16)17/h1-4,8H,5,11H2,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 774 | n/a | n/a | n/a | n/a | n/a | n/a |
F. Hoffmann-La Roche Ltd.
Curated by ChEMBL
| Assay Description Inhibition of rat kidney Kynurenine 3-hydroxylase. |
J Med Chem 40: 4378-85 (1998)
Article DOI: 10.1021/jm970467t BindingDB Entry DOI: 10.7270/Q24B30DT |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50083933
(2-Amino-4-(3-chloro-4-fluoro-phenyl)-4-oxo-but-2-e...)Show InChI InChI=1S/C10H7ClFNO3/c11-6-3-5(1-2-7(6)12)9(14)4-8(13)10(15)16/h1-3,13H,4H2,(H,15,16) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 820 | n/a | n/a | n/a | n/a | n/a | n/a |
Glaxo Wellcome Research and Development
Curated by ChEMBL
| Assay Description Inhibition of Kynurenine-3-hydroxylase enzyme isolated from the rat liver |
J Med Chem 43: 123-7 (2000)
BindingDB Entry DOI: 10.7270/Q2RX9B9B |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072245
(4-(3,4-Dichloro-phenyl)-4-oxo-butyric acid | CHEMB...)Show InChI InChI=1S/C10H8Cl2O3/c11-7-2-1-6(5-8(7)12)9(13)3-4-10(14)15/h1-2,5H,3-4H2,(H,14,15) | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Inhibition of rat brain KYN 3-OHase. |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50072254
((E)-4-(3,4-Dichloro-phenyl)-4-oxo-but-2-enoic acid...)Show InChI InChI=1S/C10H6Cl2O3/c11-7-2-1-6(5-8(7)12)9(13)3-4-10(14)15/h1-5H,(H,14,15)/b4-3+ | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
Pharmacia& Upjohn
Curated by ChEMBL
| Assay Description Compound was evaluated for inhibition of rat brain KYN 3-OHase |
Bioorg Med Chem Lett 8: 2907-12 (1999)
BindingDB Entry DOI: 10.7270/Q23X874K |
More data for this Ligand-Target Pair | |
Kynurenine 3-monooxygenase
(Rattus norvegicus) | BDBM50083950
((S)-(+)-2-Amino-4-(3-nitro-phenyl)-4-oxo-butyric a...)Show SMILES N[C@@H](CC(=O)c1cccc(c1)[N+]([O-])=O)C(O)=O Show InChI InChI=1S/C10H10N2O5/c11-8(10(14)15)5-9(13)6-2-1-3-7(4-6)12(16)17/h1-4,8H,5,11H2,(H,14,15)/t8-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 900 | n/a | n/a | n/a | n/a | n/a | n/a |
GlaxoSmithKline
Curated by ChEMBL
| Assay Description Inhibition of KMO in rat brain homogenates using kynurenine as substrate measured after 5 to 30 mins |
Bioorg Med Chem Lett 27: 2023-2028 (2017)
Article DOI: 10.1016/j.bmcl.2017.02.078 BindingDB Entry DOI: 10.7270/Q23R0W54 |
More data for this Ligand-Target Pair | |