The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28300404 |
4 |
Structural Basis of Small-Molecule Aggregate Induced Inhibition of a Protein-Protein Interaction. |
Janssen Research and Development |
| 25078315 |
7 |
Discovery of highly potent TNFa inhibitors using virtual screen. |
Peking University |
| 24974349 |
20 |
Prediction of anti-tumor chemical probes of a traditional Chinese medicine formula by HPLC fingerprinting combined with molecular docking. |
The Second People'S Hospital of Fujian Provinc |
| 24900576 |
11 |
Solvent Selection for Insoluble Ligands, a Challenge for Biological Assay Development: A TNF-?/SPD304 Study. |
The Centre For Research and Technology of Thessaly (Ce.Re.Te.Th.) |
| 18075579 |
9 |
Reaching for high-hanging fruit in drug discovery at protein-protein interfaces. |
University of California San Francisco |
| 10508435 |
61 |
Substituted isoquinolines and quinazolines as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. |
University of California |
| 15953722 |
56 |
Discovery of 3-OH-3-methylpipecolic hydroxamates: potent orally active inhibitors of aggrecanase and MMP-13. |
Pfizer |
| 32667202 |
5 |
Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-? Inhibitor. |
Huazhong University of Science and Technology |
| 31082234 |
14 |
Development of Small-Molecules Targeting Receptor Activator of Nuclear Factor-?B Ligand (RANKL)-Receptor Activator of Nuclear Factor-?B (RANK) Protein-Protein Interaction by Structure-Based Virtual Screening and Hit Optimization. |
Shanghai Jiaotong University School of Medicine |
| 8765505 |
26 |
Structural modifications of thalidomide produce analogs with enhanced tumor necrosis factor inhibitory activity. |
Celgene |
| 8759624 |
1 |
Potent inhibition of tumor necrosis factor-alpha production by tetrafluorothalidomide and tetrafluorophthalimides. |
Institute of Technology |
| 8568809 |
34 |
Substituted xanthines, pteridinediones, and related compounds as potential antiinflammatory agents. Synthesis and biological evaluation of inhibitors of tumor necrosis factor alpha. |
University of California |
| 12014967 |
25 |
Beta-aryl-succinic acid hydroxamates as dual inhibitors of matrix metalloproteinases and tumor necrosis factor alpha converting enzyme. |
Preclinical Research Novartis Pharma |
| 29173945 |
45 |
Synthesis and in vitro evaluations of 6-(hetero)-aryl-imidazo[1,2-b]pyridazine-3-sulfonamide's as an inhibitor of TNF-? production. |
Padmashri Vikhe Patil College of Arts |
| 29910080 |
8 |
Synthesis and biological evaluation of pyridine-linked indanone derivatives: Potential agents for inflammatory bowel disease. |
Yeungnam University |
| 28843845 |
2 |
Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis. |
Csir-Indian Institute of Integrative Medicine |
| 24943831 |
8 |
Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction. |
University of Santiago De Compostela |
| 24707965 |
33 |
A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1. |
Johns Hopkins University |
| 1731937 |
20 |
Reversal of enzyme regiospecificity with alternative substrates for aspartokinase I from Escherichia coli. |
University of Akron |
| 9336327 |
37 |
The pharmacological characterization of a novel selective 5-hydroxytryptamine1A receptor antagonist, NAD-299. |
Preclinical R & D, Astra Arcus |
| 19827831 |
83 |
Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes. |
Novartis |
| 19398200 |
45 |
Optimization of benzimidazole series as opioid receptor-like 1 (ORL1) antagonists: SAR study directed toward improvement of selectivity over hERG activity. |
Banyu Pharmaceutical |
| 17500511 |
19 |
Synthesis and biological evaluation of 3-aryl-3-(4-phenoxy)-propionic acid as a novel series of G protein-coupled receptor 40 agonists. |
Johnson & Johnson Pharmaceutical |
| 18393489 |
11 |
Synthesis of indoleamine 2,3-dioxygenase inhibitory analogues of the sponge alkaloid exiguamine a. |
University of British Columbia |
| 15895686 |
3 |
Glutamylsulfamoyladenosine and pyroglutamylsulfamoyladenosine are competitive inhibitors of E. coli glutamyl-tRNA synthetase. |
Crefsip |
| 16392822 |
87 |
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]-1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV. |
National Health Research Institutes |
| | 4 |
INFLUENCE OF STEREOCHEMISTRY ON ACTIVITY AND BINDING MODES FOR C(2) SYMMETRY-BASED DIOL INHIBITORS OF HIV-1 PROTEASE. |
Nci-Fcrdc |
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