The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28087272 |
6 |
Synthesis and evaluation of 5-(1H-indol-3-yl)-N-aryl-1,3,4-oxadiazol-2-amines as Bcl-2 inhibitory anticancer agents. |
Cardiff University |
| 28233676 |
35 |
Design, synthesis and preliminary biological evaluation of indole-3-carboxylic acid-based skeleton of Bcl-2/Mcl-1 dual inhibitors. |
Shandong University |
| 27810438 |
49 |
Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains. |
Shandong University |
| 27994761 |
48 |
Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins. |
Wuhan University School of Pharmaceutical Sciences |
| 27712939 |
63 |
Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites. |
China Pharmaceutical University |
| 27353532 |
6 |
Structural modification of luteolin from Flos Chrysanthemi leads to increased tumor cell growth inhibitory activity. |
Second Military Medical University |
| 26988306 |
12 |
Selective inhibitors of Bcl-2 and Bcl-xL: Balancing antitumor activity with on-target toxicity. |
Astrazeneca |
| 26558516 |
39 |
Design, synthesis and preliminary bioactivity studies of imidazolidine-2,4-dione derivatives as Bcl-2 inhibitors. |
Shandong University |
| 26421995 |
49 |
Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors. |
Shandong University |
| 26181851 |
26 |
Discovery of a Dihydroisoquinolinone Derivative (NVP-CGM097): A Highly Potent and Selective MDM2 Inhibitor Undergoing Phase 1 Clinical Trials in p53wt Tumors. |
Novartis Institutes For Biomedical Research |
| 25844895 |
61 |
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design. |
Vanderbilt University School of Medicine |
| 25679114 |
48 |
Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity. |
Abbvie |
| 25668341 |
50 |
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents. |
Universit£ |
| 25818766 |
45 |
Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. |
Shandong University |
| 25011914 |
2 |
In vitro induction of apoptosis by isosclerone from marine-derived fungus Aspergillus fumigatus. |
Pukyong National University |
| 24881567 |
73 |
Towards the next generation of dual Bcl-2/Bcl-xL inhibitors. |
Astrazeneca |
| 25313317 |
51 |
Discovery of a Potent and Selective BCL-XL Inhibitor with in Vivo Activity. |
Abbvie |
| 24944740 |
37 |
Structure-Guided Rescaffolding of Selective Antagonists of BCL-XL. |
Genentech |
| 24749893 |
123 |
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation. |
University of Michigan Medical School |
| 24095762 |
18 |
Design and application of a rigid quinazolone scaffold based on two-face Bima-helix mimicking. |
Dalian University of Technology |
| 23767404 |
97 |
Discovery of potent and selective benzothiazole hydrazone inhibitors of Bcl-XL. |
The Walter and Eliza Hall Institute of Medical Research |
| 23474389 |
2 |
Synthesis and evaluation of 3-(benzylthio)-5-(1H-indol-3-yl)-1,2,4-triazol-4-amines as Bcl-2 inhibitory anticancer agents. |
Cardiff University |
| 23448298 |
58 |
A potent and highly efficacious Bcl-2/Bcl-xL inhibitor. |
University of Michigan |
| 24900652 |
30 |
The role of the acidity of N-heteroaryl sulfonamides as inhibitors of bcl-2 family protein-protein interactions. |
Novartis Institutes For Biomedical Research |
| 23314054 |
41 |
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors. |
Dalian University of Technology |
| 23244564 |
114 |
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. |
Vanderbilt University School of Medicine |
| 23206987 |
66 |
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1. |
Dalian University of Technology |
| 21413808 |
170 |
Synopsis of some recent tactical application of bioisosteres in drug design. |
Bristol-Myers Squibb Pharmaceutical Research and Development |
| 23167494 |
18 |
An anthraquinone scaffold for putative, two-face Bim BH3a-helix mimic. |
Dalian University of Technology |
| 23047228 |
24 |
Synthesis and biological activities of polyquinoline derivatives: new Bcl-2 family protein modulators. |
Clermont Universit£ |
| 23030453 |
58 |
Structure-based discovery of BM-957 as a potent small-molecule inhibitor of Bcl-2 and Bcl-xL capable of achieving complete tumor regression. |
University of Michigan |
| 22448988 |
77 |
Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold. |
University of Michigan |
| 22608961 |
46 |
Identification of a phenylacylsulfonamide series of dual Bcl-2/Bcl-xL antagonists. |
Bristol-Myers Squibb Research |
| 22608393 |
64 |
Pyrazole and pyrimidine phenylacylsulfonamides as dual Bcl-2/Bcl-xL antagonists. |
Bristol-Myers Squibb Research |
| 20443627 |
26 |
BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. |
Sanford-Burnham Medical Research Institute |
| 18023349 |
30 |
Development of dimeric modulators for anti-apoptotic Bcl-2 proteins. |
University of Minnesota Minneapolis |
| 18237106 |
18 |
Acylpyrogallols as inhibitors of antiapoptotic Bcl-2 proteins. |
TBA |
| 17227711 |
40 |
Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1. |
University of Minnesota |
| 11728179 |
12 |
Discovery of small-molecule inhibitors of Bcl-2 through structure-based computer screening. |
Georgetown University Medical Center |
| 22172701 |
40 |
Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity. |
Second Military Medical University |
| 21684048 |
20 |
Probing the difference between BH3 groove of Mcl-1 and Bcl-2 protein: Implications for dual inhibitors design. |
Dalian University of Technology |
| 21366295 |
40 |
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity. |
The Walter and Eliza Hall Institute of Medical Research |
| 21235240 |
24 |
3-Thiomorpholin-8-oxo-8H-acenaphtho[1,2-b]pyrrole-9-carbonitrile (S1) based molecules as potent, dual inhibitors of B-cell lymphoma 2 (Bcl-2) and myeloid cell leukemia sequence 1 (Mcl-1): structure-based design and structure-activity relationship studies. |
Dalian University of Technology |
| 21033669 |
96 |
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins. |
Sanford-Burnham Medical Research Institute |
| 20925433 |
21 |
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives. |
Aristotle University of Thessaloniki |
| 20870405 |
31 |
Discovery of a potent and selective Bcl-2 inhibitor using SAR by NMR. |
Abbott Laboratories |
| 20405848 |
48 |
Design, synthesis, and interaction study of quinazoline-2(1H)-thione derivatives as novel potential Bcl-xL inhibitors. |
Chinese Academy of Sciences |
| 20441222 |
37 |
Vaccinia virus virulence factor N1L is a novel promising target for antiviral therapeutic intervention. |
Institute For Medical Research |
| 19329314 |
32 |
Diversity-oriented synthesis of a cytisine-inspired pyridone library leading to the discovery of novel inhibitors of Bcl-2. |
Infinity Pharmaceuticals |
| 19217289 |
8 |
Atropisomeric small molecule Bcl-2 ligands: determination of bioactive conformation. |
Ucb Pharma |
| 19027294 |
80 |
Tetrahydroisoquinoline amide substituted phenyl pyrazoles as selective Bcl-2 inhibitors. |
Ucb Pharma |
| 18841882 |
3 |
Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins. |
Abbott Laboratories |
| 17692431 |
48 |
Structure-activity relationships of Bak derived peptides: affinity and specificity modulations by amino acid replacement. |
University of Montpellier |
| 17552510 |
9 |
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins. |
University of Michigan |
| 17378545 |
10 |
Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. |
University of Michigan |
| 17181155 |
23 |
Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. |
University of Minnesota |
| 17034116 |
28 |
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins. |
University of Michigan |
| 16451081 |
132 |
Discovery and structure-activity relationship of antagonists of B-cell lymphoma 2 family proteins with chemopotentiation activity in vitro and in vivo. |
Abbott Laboratories |
| 16137879 |
16 |
A chemical strategy to promote helical peptide-protein interactions involved in apoptosis. |
University of Illinois At Urbana-Champaign |
| 32035700 |
93 |
Pro-apoptotic carboxamide analogues of natural fislatifolic acid targeting Mcl-1 and Bcl-2. |
Universit£ |
| 31606346 |
58 |
Discovery and optimization of covalent Bcl-xL antagonists. |
Astrazeneca |
| 31129454 |
51 |
The chemical biology of apoptosis: Revisited after 17 years. |
Tsinghua University |
| 30929420 |
108 |
Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. |
Vanderbilt University School of Medicine |
| 31580668 |
29 |
Hot-Spots of Mcl-1 Protein. |
Normandie Univiversit� |
| 31339316 |
98 |
Structure-Guided Discovery of a Selective Mcl-1 Inhibitor with Cellular Activity. |
Servier Research Institute of Medicinal Chemistry |
| 31736296 |
52 |
Discovery and in Vivo Evaluation of Macrocyclic Mcl-1 Inhibitors Featuring an ?-Hydroxy Phenylacetic Acid Pharmacophore or Bioisostere. |
TBA |
| 31971799 |
74 |
Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins. |
National Institute of Chemistry |
| 30769242 |
14 |
Clinical candidates modulating protein-protein interactions: The fragment-based experience. |
Taros Chemicals |
| 31079964 |
35 |
Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors. |
Shandong University |
| 30594434 |
22 |
Design, synthesis, and bioactivity evaluation of novel Bcl-2/HDAC dual-target inhibitors for the treatment of multiple myeloma. |
Wuhan Polytechnic University |
| 31389699 |
30 |
Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. |
TBA |
| 31188592 |
39 |
Why Some Targets Benefit from beyond Rule of Five Drugs. |
Boston University |
| 26982372 |
73 |
Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like ?-Helical Mimetics. |
Dalian University of Technology |
| 26620718 |
37 |
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors. |
Shandong University |
| 22739087 |
3 |
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein. |
Soochow University |
| 30278333 |
40 |
Development of high potent and selective Bcl-2 inhibitors bearing the structural elements of natural product artemisinin. |
Shanghai Institute of Materia Medica (Simm) |
| 30170927 |
20 |
Discovery and development of substituted tyrosine derivatives as Bcl-2/Mcl-1 inhibitors. |
Shandong University |
| 28926247 |
8 |
Beyond the Rule of 5: Lessons Learned from AbbVie's Drugs and Compound Collection. |
Abbvie |
| 29620890 |
25 |
Mapping the Efficiency and Physicochemical Trajectories of Successful Optimizations. |
Glaxosmithkline |
| 29229225 |
40 |
Design, synthesis and pharmacological evaluation of new acyl sulfonamides as potent and selective Bcl-2 inhibitors. |
Shanghai Institute of Materia Medica (Simm) |
| 29453135 |
99 |
Dual inhibitors of the pro-survival proteins Bcl-2 and Mcl-1 derived from natural compound meiogynin A. |
Universit£ |
| 29407973 |
35 |
Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents. |
Hunan Provinc |
| 27749061 |
26 |
Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules. |
University of Maryland |
| 28866374 |
32 |
1-Phenyl-1H-indole derivatives as a new class of Bcl-2/Mcl-1 dual inhibitors: Design, synthesis, and preliminary biological evaluation. |
Shandong University |
| 29323899 |
120 |
Optimization of Potent and Selective Tricyclic Indole Diazepinone Myeloid Cell Leukemia-1 Inhibitors Using Structure-Based Design. |
Vanderbilt University School of Medicine |
| 28343875 |
58 |
Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors. |
Shenyang Pharmaceutical University |
| 28355052 |
5 |
Design, Synthesis, and Experimental Validation of Peptide Ligands Targeting Mycobacterium tuberculosis s Factors. |
Indian Institute of Science |
| 11496832 |
7 |
Potential of pyrazolooxadiazinone derivatives as serine protease inhibitors. |
UniversitÀ |
| 18522386 |
14 |
Triazolopyrimidine-based dihydroorotate dehydrogenase inhibitors with potent and selective activity against the malaria parasite Plasmodium falciparum. |
University of Texas At Dallas |
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