Found 31 hits of Enzyme Inhibition Constant Data Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329390
(4'-(5-(1-(4-tert-butylphenyl)-1-hydroxy-3-(pyrroli...)Show SMILES CC(C)(C)c1ccc(cc1)C(O)(CCN1CCCC1)c1ccc(Cl)c(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C38H42ClNO4/c1-37(2,3)31-12-14-32(15-13-31)38(43,21-24-40-22-4-5-23-40)33-16-19-35(39)30(26-33)20-25-44-34-17-10-28(11-18-34)27-6-8-29(9-7-27)36(41)42/h6-19,26,43H,4-5,20-25H2,1-3H3,(H,41,42) | PDB
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PubMed
| 40 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329389
(4'-(5-(1-(4-tert-butylphenyl)-1-hydroxy-3-morpholi...)Show SMILES CC(C)(C)c1ccc(cc1)C(O)(CCN1CCOCC1)c1ccc(Cl)c(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C38H42ClNO5/c1-37(2,3)31-10-12-32(13-11-31)38(43,19-20-40-21-24-44-25-22-40)33-14-17-35(39)30(26-33)18-23-45-34-15-8-28(9-16-34)27-4-6-29(7-5-27)36(41)42/h4-17,26,43H,18-25H2,1-3H3,(H,41,42) | PDB
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PubMed
| 110 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329388
(4'-(5-(1-(4-bromophenyl)-1-hydroxy-3-morpholinopro...)Show SMILES OC(=O)c1ccc(cc1)-c1ccc(OCCc2cc(ccc2Cl)C(O)(CCN2CCOCC2)c2ccc(Br)cc2)cc1 Show InChI InChI=1S/C34H33BrClNO5/c35-30-10-7-28(8-11-30)34(40,16-17-37-18-21-41-22-19-37)29-9-14-32(36)27(23-29)15-20-42-31-12-5-25(6-13-31)24-1-3-26(4-2-24)33(38)39/h1-14,23,40H,15-22H2,(H,38,39) | PDB
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| 200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329386
(4'-(2-chloro-5-(1-(4-chlorophenyl)-1-hydroxy-3-mor...)Show SMILES OC(=O)c1ccc(cc1)-c1ccc(OCCc2cc(ccc2Cl)C(O)(CCN2CCOCC2)c2ccc(Cl)cc2)cc1 Show InChI InChI=1S/C34H33Cl2NO5/c35-30-10-7-28(8-11-30)34(40,16-17-37-18-21-41-22-19-37)29-9-14-32(36)27(23-29)15-20-42-31-12-5-25(6-13-31)24-1-3-26(4-2-24)33(38)39/h1-14,23,40H,15-22H2,(H,38,39) | PDB
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| 220 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329387
(4'-(2-chloro-5-(1-(4-chlorophenyl)-1-hydroxyethyl)...)Show SMILES CC(O)(c1ccc(Cl)cc1)c1ccc(Cl)c(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C29H24Cl2O4/c1-29(34,23-8-11-25(30)12-9-23)24-10-15-27(31)22(18-24)16-17-35-26-13-6-20(7-14-26)19-2-4-21(5-3-19)28(32)33/h2-15,18,34H,16-17H2,1H3,(H,32,33) | PDB
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| 460 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329385
(4'-(2-(4-(4-(dimethylamino)-1-hydroxy-1-phenylbuty...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1ccc(OCCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C33H35NO5/c1-34(2)22-6-21-33(37,28-7-4-3-5-8-28)29-15-19-31(20-16-29)39-24-23-38-30-17-13-26(14-18-30)25-9-11-27(12-10-25)32(35)36/h3-5,7-20,37H,6,21-24H2,1-2H3,(H,35,36) | PDB
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| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329380
(4'-(2-(3-(4-(dimethylamino)-1-hydroxy-1-phenylbuty...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1cccc(OCCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C33H35NO5/c1-34(2)21-7-20-33(37,28-8-4-3-5-9-28)29-10-6-11-31(24-29)39-23-22-38-30-18-16-26(17-19-30)25-12-14-27(15-13-25)32(35)36/h3-6,8-19,24,37H,7,20-23H2,1-2H3,(H,35,36) | PDB
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| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329379
(4'-(3-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)p...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1cccc(CCOc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C33H35NO4/c1-34(2)22-7-21-33(37,29-9-4-3-5-10-29)30-11-6-8-25(24-30)20-23-38-31-18-16-27(17-19-31)26-12-14-28(15-13-26)32(35)36/h3-6,8-19,24,37H,7,20-23H2,1-2H3,(H,35,36) | PDB
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| 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329378
(4'-(2-(3-(4-(dimethylamino)-1-hydroxy-1-phenylbuty...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1cccc(OCCc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C33H35NO4/c1-34(2)22-7-21-33(37,29-8-4-3-5-9-29)30-10-6-11-31(24-30)38-23-20-25-12-14-26(15-13-25)27-16-18-28(19-17-27)32(35)36/h3-6,8-19,24,37H,7,20-23H2,1-2H3,(H,35,36) | PDB
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| 4.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329375
(3'-(2-(3-(4-(dimethylamino)-1-hydroxy-1-phenylbuty...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1cccc(OCCc2cccc(c2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C33H35NO4/c1-34(2)21-8-20-33(37,29-11-4-3-5-12-29)30-13-7-14-31(24-30)38-22-19-25-9-6-10-28(23-25)26-15-17-27(18-16-26)32(35)36/h3-7,9-18,23-24,37H,8,19-22H2,1-2H3,(H,35,36) | PDB
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| 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329377
(4'-((3-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1cccc(OCc2ccc(cc2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C32H33NO4/c1-33(2)21-7-20-32(36,28-8-4-3-5-9-28)29-10-6-11-30(22-29)37-23-24-12-14-25(15-13-24)26-16-18-27(19-17-26)31(34)35/h3-6,8-19,22,36H,7,20-21,23H2,1-2H3,(H,34,35) | PDB
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| 5.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329381
(3'-((4-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1ccc(OCc2cccc(c2)-c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C32H33NO4/c1-33(2)21-7-20-32(36,28-10-4-3-5-11-28)29-16-18-30(19-17-29)37-23-24-8-6-9-27(22-24)25-12-14-26(15-13-25)31(34)35/h3-6,8-19,22,36H,7,20-21,23H2,1-2H3,(H,34,35) | PDB
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| 5.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329382
(3'-(2-(4-(4-(dimethylamino)-1-hydroxy-1-phenylbuty...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1ccc(OCCc2cccc(c2)-c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C33H35NO4/c1-34(2)22-7-21-33(37,29-10-4-3-5-11-29)30-16-18-31(19-17-30)38-23-20-25-8-6-9-28(24-25)26-12-14-27(15-13-26)32(35)36/h3-6,8-19,24,37H,7,20-23H2,1-2H3,(H,35,36) | PDB
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| 8.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329384
(4'-(2-(4-(4-(dimethylamino)-1-hydroxy-1-phenylbuty...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1ccc(OCCc2ccc(cc2)-c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C33H35NO4/c1-34(2)23-6-22-33(37,29-7-4-3-5-8-29)30-17-19-31(20-18-30)38-24-21-25-9-11-26(12-10-25)27-13-15-28(16-14-27)32(35)36/h3-5,7-20,37H,6,21-24H2,1-2H3,(H,35,36) | PDB
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| 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329376
(3'-((3-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1cccc(OCc2cccc(c2)-c2ccc(cc2)C(O)=O)c1 Show InChI InChI=1S/C32H33NO4/c1-33(2)20-8-19-32(36,28-11-4-3-5-12-28)29-13-7-14-30(22-29)37-23-24-9-6-10-27(21-24)25-15-17-26(18-16-25)31(34)35/h3-7,9-18,21-22,36H,8,19-20,23H2,1-2H3,(H,34,35) | PDB
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| 2.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329383
(4'-((4-(4-(dimethylamino)-1-hydroxy-1-phenylbutyl)...)Show SMILES CN(C)CCCC(O)(c1ccccc1)c1ccc(OCc2ccc(cc2)-c2ccc(cc2)C(O)=O)cc1 Show InChI InChI=1S/C32H33NO4/c1-33(2)22-6-21-32(36,28-7-4-3-5-8-28)29-17-19-30(20-18-29)37-23-24-9-11-25(12-10-24)26-13-15-27(16-14-26)31(34)35/h3-5,7-20,36H,6,21-23H2,1-2H3,(H,34,35) | PDB
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| 8.30E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of Bcl-2 by fluorescence polarization assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50060993
(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)Show InChI InChI=1S/C13H9FO2/c14-12-7-5-10(6-8-12)9-1-3-11(4-2-9)13(15)16/h1-8H,(H,15,16) | PDB
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| n/a | n/a | n/a | 4.30E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay in presence of 500 uM 1,1-bis(4-chlorophenyl)-3-(dimethylamino)propan-1-ol |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329371
(1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperaz...)Show InChI InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3 | PDB
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PubMed
| n/a | n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329369
((R)-1-(4-chlorophenyl)-4-(dimethylamino)-1-phenylb...)Show InChI InChI=1S/C18H22ClNO/c1-20(2)14-6-13-18(21,15-7-4-3-5-8-15)16-9-11-17(19)12-10-16/h3-5,7-12,21H,6,13-14H2,1-2H3 | PDB
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Similars
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| n/a | n/a | n/a | 8.00E+4 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50329370
(4-(dimethylamino)-1,1-diphenylbutan-1-ol | CHEMBL1...)Show InChI InChI=1S/C18H23NO/c1-19(2)15-9-14-18(20,16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-8,10-13,20H,9,14-15H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 5.00E+6 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-XL by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50329369
((R)-1-(4-chlorophenyl)-4-(dimethylamino)-1-phenylb...)Show InChI InChI=1S/C18H22ClNO/c1-20(2)14-6-13-18(21,15-7-4-3-5-8-15)16-9-11-17(19)12-10-16/h3-5,7-12,21H,6,13-14H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 5.00E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-XL by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50329371
(1-((4-chlorophenyl)(phenyl)methyl)-4-methylpiperaz...)Show InChI InChI=1S/C18H21ClN2/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16/h2-10,18H,11-14H2,1H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 7.00E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-XL by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329368
(1,1-bis(4-chlorophenyl)-4-(dimethylamino)butan-1-o...)Show InChI InChI=1S/C18H21Cl2NO/c1-21(2)13-3-12-18(22,14-4-8-16(19)9-5-14)15-6-10-17(20)11-7-15/h4-11,22H,3,12-13H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329372
((S)-2-amino-1-(2-chloro-4-fluorophenyl)-1-phenylet...)Show InChI InChI=1S/C14H13ClFNO/c15-13-8-11(16)6-7-12(13)14(18,9-17)10-4-2-1-3-5-10/h1-8,18H,9,17H2 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | n/a | 2.50E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329373
(3'-ethylbiphenyl-4-carboxylic acid | CHEMBL1269503)Show InChI InChI=1S/C15H14O2/c1-2-11-4-3-5-14(10-11)12-6-8-13(9-7-12)15(16)17/h3-10H,2H2,1H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.00E+4 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay in presence of 500 uM 1,1-bis(4-chlorophenyl)-3-(dimethylamino)propan-1-ol |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329374
(4'-ethyl-biphenyl-4-carboxylic acid | 4'-ethylbiph...)Show InChI InChI=1S/C15H14O2/c1-2-11-3-5-12(6-4-11)13-7-9-14(10-8-13)15(16)17/h3-10H,2H2,1H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 3.00E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329374
(4'-ethyl-biphenyl-4-carboxylic acid | 4'-ethylbiph...)Show InChI InChI=1S/C15H14O2/c1-2-11-3-5-12(6-4-11)13-7-9-14(10-8-13)15(16)17/h3-10H,2H2,1H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay in presence of 500 uM 1,1-bis(4-chlorophenyl)-3-(dimethylamino)propan-1-ol |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329373
(3'-ethylbiphenyl-4-carboxylic acid | CHEMBL1269503)Show InChI InChI=1S/C15H14O2/c1-2-11-4-3-5-14(10-11)12-6-8-13(9-7-12)15(16)17/h3-10H,2H2,1H3,(H,16,17) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50329370
(4-(dimethylamino)-1,1-diphenylbutan-1-ol | CHEMBL1...)Show InChI InChI=1S/C18H23NO/c1-19(2)15-9-14-18(20,16-10-5-3-6-11-16)17-12-7-4-8-13-17/h3-8,10-13,20H,9,14-15H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 2.00E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Apoptosis regulator Bcl-2
(Homo sapiens (Human)) | BDBM50060993
(4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID | 4'-Flu...)Show InChI InChI=1S/C13H9FO2/c14-12-7-5-10(6-8-12)9-1-3-11(4-2-9)13(15)16/h1-8H,(H,15,16) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
DrugBank
MCE
MMDB
PC cid
PC sid
PDB
UniChem
Patents
| Article
PubMed
| n/a | n/a | n/a | 4.00E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-2 by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
Bcl-2-like protein 1
(Homo sapiens (Human)) | BDBM50329368
(1,1-bis(4-chlorophenyl)-4-(dimethylamino)butan-1-o...)Show InChI InChI=1S/C18H21Cl2NO/c1-21(2)13-3-12-18(22,14-4-8-16(19)9-5-14)15-6-10-17(20)11-7-15/h4-11,22H,3,12-13H2,1-2H3 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | 4.50E+5 | n/a | n/a | n/a | n/a | n/a |
Abbott Laboratories
Curated by ChEMBL
| Assay Description
Binding affinity to Bcl-XL by NMR titration assay |
Bioorg Med Chem Lett 20: 6587-91 (2010)
Article DOI: 10.1016/j.bmcl.2010.09.033
BindingDB Entry DOI: 10.7270/Q2J103C3 |
More data for this
Ligand-Target Pair | |
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