95 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
28111140	24	Discovery of core-structurally novel PTP1B inhibitors with specific selectivity containing oxindole-fused spirotetrahydrofurochroman by one-pot reaction.	East China Normal University
28189419	20	Furanoterpenes, new types of protein tyrosine phosphatase 1B inhibitors, from two Indonesian marine sponges, Ircinia and Spongia spp.	Tohoku Medical And Pharmaceutical University
28202316	3	An epigenetic modifier induces production of (10'S)-verruculide B, an inhibitor of protein tyrosine phosphatases by Phoma sp. nov. LG0217, a fungal endophyte of Parkinsonia microphylla.	University Of Arizona
27123900	17	Discovery of novel, high potent, ABC type PTP1B inhibitors with TCPTP selectivity and cellular activity.	Qilu University Of Technology
27353889	34	The design strategy of selective PTP1B inhibitors over TCPTP.	Chinese Academy Of Sciences
26961283	10	In vitro and in silico PTP-1B inhibition and in vivo antidiabetic activity of semisynthetic moronic acid derivatives.	Universidad Aut£Noma Del Estado De Morelos
26774579	140	Design, synthesis and in vitro activity of phidianidine B derivatives as novel PTP1B inhibitors with specific selectivity.	Shanghai Institute Of Materia Medica
26481657	20	Novel, potent, selective and cellular active ABC type PTP1B inhibitors containing (methanesulfonyl-phenyl-amino)-acetic acid methyl ester phosphotyrosine mimetic.	Qilu University Of Technology
25264584	20	Synthesis of oleanolic acid derivatives: In vitro, in vivo and in silico studies for PTP-1B inhibition.	Universidad Aut£Noma Del Estado De Morelos
26100442	17	Discovery of novel, potent, selective and cellular active ADC type PTP1B inhibitors via fragment-docking-oriented de novel design.	Qilu University Of Technology
25921264	21	Perspective: Tyrosine phosphatases as novel targets for antiplatelet therapy.	Sanford-Burnham Medical Research Institute
25907364	29	A potent and selective inhibitor for the UBLCP1 proteasome phosphatase.	Indiana University
25872983	57	Design and synthesis of novel 1,2-dithiolan-4-yl benzoate derivatives as PTP1B inhibitors.	Chinese Academy Of Sciences
25124112	54	Synthesis and biological evaluation of novel thiadiazole amides as potent Cdc25B and PTP1B inhibitors.	Liaoning Normal University
24906513	21	4-Quinolone-3-carboxylic acids as cell-permeable inhibitors of protein tyrosine phosphatase 1B.	Chinese Academy Of Sciences
25497963	19	Bioactive constituents from the green alga Caulerpa racemosa.	Nanchang University
24721313	21	Synthesis and evaluation of several oleanolic acid glycoconjugates as protein tyrosine phosphatase 1B inhibitors.	North-West University
24287560	61	Synthesis, biological activity and structure-activity relationships of new benzoic acid-based protein tyrosine phosphatase inhibitors endowed with insulinomimetic effects in mouse C2C12 skeletal muscle cells.	University Of Messina
24090912	54	Design, synthesis, and biological evaluation of novel 2-ethyl-5-phenylthiazole-4-carboxamide derivatives as protein tyrosine phosphatase 1B inhibitors with improved cellular efficacy.	Chinese Academy Of Sciences
24083656	52	Substrate-based fragment identification for the development of selective, nonpeptidic inhibitors of striatal-enriched protein tyrosine phosphatase.	Yale University
24012179	30	Calix[4]arene methylenebisphosphonic acids as inhibitors of protein tyrosine phosphatase 1B.	National Academy Of Sciences Of Ukraine
23957426	14	Identification of cryptotanshinone as an inhibitor of oncogenic protein tyrosine phosphatase SHP2 (PTPN11).	Case Western Reserve University
23942421	43	The first synthesis of natural disulfide bruguiesulfurol and biological evaluation of its derivatives as a novel scaffold for PTP1B inhibitors.	Chinese Academy Of Sciences
23713581	75	A potent and selective small-molecule inhibitor for the lymphoid-specific tyrosine phosphatase (LYP), a target associated with autoimmune diseases.	Indiana University School Of Medicine
23528300	48	Design and synthesis of 2-substituted benzoxazoles as novel PTP1B inhibitors.	Aurigene Discovery Technologies
23387824	18	Sesquiterpenes from the rhizomes of Curcuma heyneana.	University Of Toyama
23305444	171	Discovery and evaluation of novel inhibitors of mycobacterium protein tyrosine phosphatase B from the 6-Hydroxy-benzofuran-5-carboxylic acid scaffold.	Indiana University School Of Medicine
23122522	25	Discovery of di-indolinone as a novel scaffold for protein tyrosine phosphatase 1B inhibitors.	East China University Of Science And Technology
23067554	37	Synthesis and biological evaluation of 4,4-dimethyl lithocholic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.	East China Normal University
23043764	70	Design, synthesis, and evaluation of 2-substituted ethenesulfonic acid ester derivatives as protein tyrosine phosphatase 1B inhibitors.	Shanghai Jiao Tong University
22444684	9	Bromophenols as inhibitors of protein tyrosine phosphatase 1B with antidiabetic properties.	Chinese Academy Of Sciences
22424978	23	Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.	Advinus Therapeutics
22381357	41	New 4-[(5-arylidene-2-arylimino-4-oxo-3-thiazolidinyl)methyl]benzoic acids active as protein tyrosine phosphatase inhibitors endowed with insulinomimetic effect on mouse C2C12 skeletal muscle cells.	University Of Messina
20153651	37	Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity.	Chinese Academy Of Sciences
17728130	36	2-O-carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity.	Inha University
17543532	46	5-Arylidene-2,4-thiazolidinediones as inhibitors of protein tyrosine phosphatases.	Universit£
17368023	24	Methylenedisalicylic acid derivatives: new PTP1B inhibitors that confer resistance to diet-induced obesity.	Inha University
11741477	37	Structure of protein tyrosine phosphatase 1B in complex with inhibitors bearing two phosphotyrosine mimetics.	University Of Waterloo
22318165	85	Exploration ofa-aminophosphonate N-derivatives as novel, potent and selective inhibitors of protein tyrosine phosphatases.	Shanxi University
22189136	25	Discovery of potent, selective and orally bioavailable triaryl-sulfonamide based PTP1B inhibitors.	M.S. University Of Baroda
21745700	20	Click to a focused library of benzyl 6-triazolo(hydroxy)benzoic glucosides: novel construction of PTP1B inhibitors on a sugar scaffold.	East China University Of Science And Technology
21680062	77	Synthesis and biological evaluation of (±)-3-(2-(2-fluorobenzyloxy) naphthalen-6-yl)-2-aminopropanoic acid derivatives as novel PTP1B inhibitors.	Yanbian University
20850970	27	Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-¿ activators.	Inha University
21669525	18	Small molecule inhibitors of SHP2 tyrosine phosphatase discovered by virtual screening.	Indiana University
21665482	62	Facile fabrication of promising protein tyrosine phosphatase (PTP) inhibitor entities based on 'clicked' serine/threonine-monosaccharide hybrids.	East China University Of Science And Technology
21251827	60	A unique and rapid approach toward the efficient development of novel protein tyrosine phosphatase (PTP) inhibitors based on 'clicked' pseudo-glycopeptides.	East China University Of Science And Technology
20731359	29	A focused library of protein tyrosine phosphatase inhibitors.	Brown University
20627471	54	Synthesis and evaluation of some novel dibenzo[b,d]furan carboxylic acids as potential anti-diabetic agents.	Glenmark Research Center
20806783	2	Bioactivity-guided isolation of 1,2,3,4,6-Penta-O-galloyl-D-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor.	University Of Vienna
20472439	37	Dammaranes from Gynostemma pentaphyllum and synthesis of their derivatives as inhibitors of protein tyrosine phosphatase 1B.	Chinese Academy Of Sciences
20363629	49	Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B.	Chinese Academy Of Sciences
19889539	49	Fragment-based discovery of selective inhibitors of the Mycobacterium tuberculosis protein tyrosine phosphatase PtpA.	University Of California
19782562	10	Isolation of the protein tyrosine phosphatase 1B inhibitory metabolite from the marine-derived fungus Cosmospora sp. SF-5060.	Silla University
20000419	51	Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer.	Incyte
19846303	59	Synthesis and biological evaluation of heterocyclic ring-substituted maslinic acid derivatives as novel inhibitors of protein tyrosine phosphatase 1B.	East China Normal University
19810703	102	Knowledge-based characterization of similarity relationships in the human protein-tyrosine phosphatase family for rational inhibitor design.	University Of Miami
19783142	27	Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects.	Inha University
19349096	81	Synthesis and evaluation of some novel isochroman carboxylic acid derivatives as potential anti-diabetic agents.	Glenmark Research Center
18722777	37	Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity.	Inha University
18707891	152	Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities.	Chinese Academy Of Sciences
18579388	18	Illudalic acid as a potential LAR inhibitor: synthesis, SAR, and preliminary studies on the mechanism of action.	Chinese Academy Of Sciences
18037290	66	Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines.	Incyte
17705360	76	Structure-based optimization of protein tyrosine phosphatase 1B inhibitors: from the active site to the second phosphotyrosine binding site.	Wyeth Research
17692525	33	Mono- and disalicylic acid derivatives: PTP1B inhibitors as potential anti-obesity drugs.	Inha University
17394300	35	Development of molecular probes for second-site screening and design of protein tyrosine phosphatase inhibitors.	Institute For Medical Research
16759857	59	Design and synthesis of potent, non-peptidic inhibitors of HPTPbeta.	Procter & Gamble Pharmaceuticals
16716588	9	A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases.	Amherst College
16220970	7	Structure-based design and discovery of protein tyrosine phosphatase inhibitors incorporating novel isothiazolidinone heterocyclic phosphotyrosine mimetics.	Incyte
15013020	94	Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.	Merck Frosst Centre For Therapeutic Research
13678400	9	Fragment screening and assembly: a highly efficient approach to a selective and cell active protein tyrosine phosphatase 1B inhibitor.	Abbott Laboratories
12852966	23	Formylchromone derivatives as a novel class of protein tyrosine phosphatase 1B inhibitors.	Inha University
12238924	145	Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.	Novo Nordisk
28395151	21	Discovery and evaluation of the hybrid of bromophenol and saccharide as potent and selective protein tyrosine phosphatase 1B inhibitors.	Chinese Academy Of Sciences
22380772	34	Secondary/tertiary benzenesulfonamides with inhibitory action against the cytosolic human carbonic anhydrase isoforms I and II.	Ataturk University
25352216	105	A Molecular Dynamics Investigation of Mycobacterium tuberculosis Prenyl Synthases: Conformational Flexibility and Implications for Computer-aided Drug Discovery.	University Of California San Diego
2971798	9	[3H]SCH 23390 labels both dopamine-1 and 5-hydroxytryptamine1c receptors in the choroid plexus.	University Of Pennsylvania
9224570	23	Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin.	Massachusetts Institute Of Technology
17465519	2	A fragment-based approach for the discovery of isoform-specific p38alpha inhibitors.	Burnham Institute For Medical Research
17116397	9	Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase.	Tokyo Institute Of Technology