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118 articles for thisTarget

The following articles (labelled with PubMed ID or TBD) are for your review
PMIDDataArticle TitleOrganization
28319392 216 Scaffold Repurposing of Nucleosides (Adenosine Receptor Agonists): Enhanced Activity at the Human Dopamine and Norepinephrine Sodium Symporters.EBI National Institute of Diabetes and Digestive and Kidney Diseases
28089699 63 Investigation of piperazine benzamides as humanßEBI Merck
3560162 3 Synthesis and antiarrhythmic activity of novel 3-alkyl-1-[omega-[4-[(alkylsulfonyl)amino]phenyl]-omega- hydroxyalkyl]-1H-imidazolium salts and related compounds.EBI TBA
2878080 1 6,7-Dichloro-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinoline . A structurally novel beta-adrenergic receptor blocking agent.EBI TBA
6124637 18 Syntheses and adrenergic agonist properties of ring-fluorinated isoproterenols.EBI TBA
11459642 39 Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1.EBI Nippon Roche Research Center
26709102 142 Discovery of Vibegron: A Potent and Selectiveß3 Adrenergic Receptor Agonist for the Treatment of Overactive Bladder.EBI Merck Research Laboratories
26125514 40 Discovery of Novel Indazole Derivatives as Highly Potent and Selective Humanß3-Adrenergic Receptor Agonists with the Possibility of Having No Cardiovascular Side Effects.EBI Asahi Kasei Pharma
24835980 98 Discovery of TD-4306, a long-actingß2-agonist for the treatment of asthma and COPD.EBI Theravance
24813741 110 Multivalent design of long-actingß(2)-adrenoceptor agonists incorporating biarylamines.EBI Theravance
16640337 47 Biarylaniline phenethanolamines as potent and selective beta3 adrenergic receptor agonists.EBI Glaxosmithkline
23614528 121 Synthesis and in vitro and in vivo characterization of highlyß1-selectiveß-adrenoceptor partial agonists.EBI University of Nottingham
21870877 119 Synthesis and characterization of high-affinity 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene-labeled fluorescent ligands for humanß-adrenoceptors.EBI University of Nottingham
11806709 63 Synthesis and evaluation of potent and selective beta(3) adrenergic receptor agonists containing acylsulfonamide, sulfonylsulfonamide, and sulfonylurea carboxylic acid isosteres.EBI Glaxosmithkline
12443779 44 2-(Dimethylaminomethyl)-tetrahydroisoxazolopyridobenzazepine derivatives. Synthesis of a new 5-HT(2C) antagonist with potential anxiolytic properties.EBI Janssen-Cilag
21925889 48 The discovery of long-acting saligeninß2 adrenergic receptor agonists incorporating a urea group.EBI Glaxosmithkline
21696967 51 The discovery of long-acting saligeninß2 adrenergic receptor agonists incorporating hydantoin or uracil rings.EBI Glaxosmithkline
20462258 50 Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating metabolic inactivation: an antedrug approach.EBI Glaxosmithkline
19317397 62 Synthesis and structure-activity relationships of long-acting beta2 adrenergic receptor agonists incorporating arylsulfonamide groups.EBI Glaxosmithkline
15908203 23 QSAR analysis of thiazole benzenesulfonamide substituted 3-pyridylethanolamines as beta3-adrenergic receptor agonist.EBI S.G.S.I.T.S.
22313227 78 Radiosynthesis and evaluation of an (18)F-labeled positron emission tomography (PET) radioligand for brain histamine subtype-3 receptors based on a nonimidazole 2-aminoethylbenzofuran chemotype.EBI National Institute of Mental Health
24900353 6 Combination of a Beta adrenoceptor modulator and a norepinephrine-serotonin uptake inhibitor for the treatment of obesity.EBI TBA
21207959 69 Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging.EBI National Institute of Mental Health
20181479 177 Heterocyclic acetamide and benzamide derivatives as potent and selective beta3-adrenergic receptor agonists with improved rodent pharmacokinetic profiles.EBI Merck Research Laboratories
19963380 38 Synthetic studies and pharmacological evaluations on the MDMA ('Ecstasy') antagonist nantenine.EBI Hunter College and The Graduate Center of The City University of New York
19608416 29 Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and molecular modeling based on the solved X-ray structure of the beta2-adrenergic receptor: part 6.EBI Astellas Pharma
19581100 162 Discovery of novel thiourea derivatives as potent and selective beta3-adrenergic receptor agonists.EBI Astellas Pharma
19232786 72 Discovery of novel acetanilide derivatives as potent and selective beta3-adrenergic receptor agonists.EBI Astellas Pharma
18651730 123 Discovery of a novel series of benzoic acid derivatives as potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. 3. Phenylethanolaminotetraline (PEAT) skeleton containing biphenyl or biphenyl ether moiety.EBI Astellas Pharma
18083578 16 Stereospecific synthesis and bio-activity of novel beta(3)-adrenoceptor agonists and inverse agonists.EBI Universit£
18307290 97 Discovery of a novel series of biphenyl benzoic acid derivatives as potent and selective human beta3-adrenergic receptor agonists with good oral bioavailability. Part I.EBI Astellas Pharma
15603933 28 Discovery of a novel, potent and selective human beta3-adrenergic receptor agonist.EBI Fujisawa Pharmaceutical
15482914 25 Azaadamantane benzamide 5-HT4 agonists: gastrointestinal prokinetic SC-54750.EBI Pfizer
12502364 17 Relationship between stereochemistry and the beta3-adrenoceptor agonistic activity of 4'-hydroxynorephedrine derivative as an agent for treatment of frequent urination and urinary incontinence.EBI Kissei Pharmaceutical
11311069 64 (4-Piperidin-1-yl)phenyl amides: potent and selective human beta(3) agonists.EBI Wyeth-Ayerst Research
1976812 62 Synthesis of novel (aryloxy)propanolamines and related compounds possessing both class II and class III antiarrhythmic activity.EBI Berlex Laboratories
15149682 25 Potent and selective, sulfamide-based human beta 3-adrenergic receptor agonists.EBI Pfizer
11714605 39 Beta 3 agonists. Part 1: evolution from inception to BMS-194449.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
 13 A simplified template approach towards the synthesis of a potent beta-3 adrenoceptor agonist at the human receptorEBI TBA
21615150 14 Progress in structure based drug design for G protein-coupled receptors.EBI Heptares Therapeutics
21353541 25 Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective humanß3 adrenergic receptor agonists.EBI Merck Research Laboratories
20833036 221 Thienopyrimidines asß3-adrenoceptor agonists: hit-to-lead optimization.EBI 4Sc
20813948 63 Spiroindolones, a potent compound class for the treatment of malaria.EBI Swiss Tropical and Public Health Institute
20434333 111 A vHTS approach for the identification of beta-adrenoceptor ligands.EBI 4Sc
19767208 33 Discovery and optimization of novel 4-[(aminocarbonyl)amino]-N-[4-(2-aminoethyl)phenyl]benzenesulfonamide ghrelin receptor antagonists.EBI Merck Research Laboratories
19646882 72 Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways.EBI University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj
 21 Serotonin 5-HT4 agonist activity of a series of meso-azanoradamantane benzamidesEBI TBA
 38 Carboxyl-promoted enhancement of selectivity for the β3 adrenergic receptor. Negative charge of the sulfonic acid BMS-187413 introduces-β3 binding selectivityEBI TBA
 32 The synthesis and biological activity of some known and putative metabolites of the atypical antipsychotic agent olanzapine (LY170053)EBI TBA
 26 BMS-187257, a potent, selective, and novel heterocyclic β3 adrenergic receptor agonistEBI TBA
 37 The discovery of CP-96,021 and CP-96,486, balanced, combined, potent and orally active leukotriene D4 (LTD4)/platelet activating factor (PAF) receptor antagonists.EBI TBA
19492813 56 Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.EBI Glaxosmithkline
19366244 138 Discovery of highly potent and selective biphenylacylsulfonamide-based beta3-adrenergic receptor agonists and evaluation of physical properties as potential overactive bladder therapies: part 5.EBI Astellas Pharma
19362005 74 Synthesis and evaluation of novel phenoxypropanolamine derivatives containing acetanilides as potent and selective beta3-adrenergic receptor agonists.EBI Astellas Pharma
19329329 183 Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET.EBI Institute of Nuclear Chemistry Johannes Gutenberg-University Mainz
19081260 10 Substituted 1,2,3,4-tetrahydroquinolin-6-yloxypropanes as beta3-adrenergic receptor agonists: design, synthesis, biological evaluation and pharmacophore modeling.EBI Central Drug Research Institute
18752946 47 Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV.EBI Astellas Pharma
18701276 97 Highly functionalized 7-azaindoles as selective PPAR gamma modulators.EBI Merck Research Laboratories
18553954 126 Discovery of a novel series of biphenyl benzoic acid derivatives as highly potent and selective human beta3 adrenergic receptor agonists with good oral bioavailability. Part II.EBI Astellas Pharma
17911024 37 Potent oxindole based human beta3 adrenergic receptor agonists.EBI Eli Lilly
17632003 55 Discovery of potent and orally bioavailable heterocycle-based beta3-adrenergic receptor agonists, potential therapeutics for the treatment of obesity.EBI Pfizer
17533126 78 Arylpropanolamines: selective beta3 agonists arising from strategies to mitigate phase I metabolic transformations.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
17303428 22 Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes.EBI Università
16931005 21 Potent benzimidazolone based human beta(3)-adrenergic receptor agonists.EBI Eli Lilly
16722631 87 An integrated in silico 3D model-driven discovery of a novel, potent, and selective amidosulfonamide 5-HT1A agonist (PRX-00023) for the treatment of anxiety and depression.EBI Predix Pharmaceuticals
16392798 46 Synthesis and in vivo validation of [O-methyl-11C]2-{4-[4-(7-methoxynaphthalen-1-yl)piperazin- 1-yl]butyl}-4-methyl-2H-[1,2,4]triazine-3,5-dione: a novel 5-HT1A receptor agonist positron emission tomography ligand.EBI Columbia University College of Physicians and Surgeons
15686912 35 Tryptamine-based human beta3-adrenergic receptor agonists. Part 3: improved oral bioavailability via modification of the sulfonamide moiety.EBI Dainippon Pharmaceutical
15546708 35 Tryptamine-based human beta3-adrenergic receptor agonists. Part 2: SAR of the methylene derivatives.EBI Dainippon Pharmaceutical
15546707 60 Tryptamine-based human beta3-adrenergic receptor agonists. Part 1: SAR studies of the 7-position of the indole ring.EBI Dainippon Pharmaceutical
15177466 74 BMS-201620: a selective beta 3 agonist.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
15149647 10 Bridgehead-methyl analog of SC-53116 as a 5-HT4 agonist.EBI Pfizer
12852947 36 Development of 3D-QSAR models in cyclic ureidobenzenesulfonamides: human beta3-adrenergic receptor agonist.EBI Central Drug Research Institute
12798332 35 Cyclic amine sulfonamides as linkers in the design and synthesis of novel human beta(3) adrenergic receptor agonists.EBI Wyeth Research
12657269 52 Novel and potent human and rat beta3-adrenergic receptor agonists containing substituted 3-indolylalkylamines.EBI Dainippon Pharmaceutical
12270184 34 Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 2: arylethanolaminomethylpiperidines.EBI Wyeth Research
12270183 45 Novel substituted 4-aminomethylpiperidines as potent and selective human beta3-agonists. Part 1: aryloxypropanolaminomethylpiperidines.EBI Wyeth Research
11720857 37 4-Aminopiperidine ureas as potent selective agonists of the human beta(3)-adrenergic receptor.EBI Wyeth-Ayerst Research
11714606 31 BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor.EBI Bristol-Myers Squibb Pharmaceutical Research Institute
11327605 27 New oxadiazolidinedione derivatives as potent and selective human beta3 agonists.EBI Wyeth-Ayerst Research
11277513 25 2,4-Thiazolidinediones as potent and selective human beta3 agonists.EBI Wyeth-Ayerst Research
11212115 72 Human beta3 adrenergic receptor agonists containing cyanoguanidine and nitroethylenediamine moieties.EBI Merck Research Laboratories
11055339 59 Tetrahydroisoquinoline derivatives containing a benzenesulfonamide moiety as potent, selective human beta3 adrenergic receptor agonists.EBI Merck Research Laboratories
11052788 33 Discovery of a potent, orally bioavailable beta(3) adrenergic receptor agonist, (R)-N-[4-[2-[[2-hydroxy-2-(3-pyridinyl)ethyl]amino]ethyl]phenyl]-4-[4 -[4-(trifluoromethyl)phenyl]thiazol-2-yl]benzenesulfonamide.EBI Merck Research Laboratories
10999482 52 Human beta3-adrenergic receptor agonists containing 1,2,3-triazole-substituted benzenesulfonamides.EBI Merck Research Laboratories
10987429 69 Potent, selective 3-pyridylethanolamine beta3 adrenergic receptor agonists possessing a thiazole benzenesulfonamide pharmacophore.EBI Merck Research Laboratories
10915043 69 Substituted oxazole benzenesulfonamides as potent human beta3 adrenergic receptor agonists.EBI Merck Research Laboratories
10888325 90 Synthesis and SAR of benzyl and phenoxymethylene oxadiazole benzenesulfonamides as selective beta3 adrenergic receptor agonist antiobesity agents.EBI Merck Research Laboratories
10888324 48 Discovery of an orally bioavailable alkyl oxadiazole beta3 adrenergic receptor agonist.EBI Merck Research Laboratories
32342685 325 Discovery, Optimization, and Characterization of ML417: A Novel and Highly Selective DEBI National Institute of Neurological Disorders and Stroke
10406657 91 Potent, elective human beta3 adrenergic receptor agonists containing a substituted indoline-5-sulfonamide pharmacophore.EBI Merck Research Laboratories
10340609 15 L-770,644: a potent and selective human beta3 adrenergic receptor agonist with improved oral bioavailability.EBI Merck Research Laboratories
10201842 69 Human beta3 adrenergic receptor agonists containing imidazolidinone and imidazolone benzenesulfonamides.EBI Merck Research Laboratories
10201841 47 Human beta3 adrenergic receptor agonists containing cyclic ureidobenzenesulfonamides.EBI Merck Research Laboratories
9925722 18 Pharmacological treatment of obesity: therapeutic strategies.EBI The R. W. Johnson Pharmaceutical Research Institute
9873681 65 3-Pyridylethanolamines: potent and selective human beta 3 adrenergic receptor agonists.EBI Merck Research Laboratories
30605331 236 Design and in Vivo Characterization of AEBI Medical College of Wisconsin
9873496 80 3-Pyridyloxypropanolamine agonists of the beta 3 adrenergic receptor with improved pharmacokinetic properties.EBI Merck Research Laboratories
9871717 72 Discovery of L-755,507: a subnanomolar human beta 3 adrenergic receptor agonist.EBI Merck Research Laboratories
9871716 94 Potent, selective benzenesulfonamide agonists of the human beta 3 adrenergic receptor.EBI Merck Research Laboratories
31620230 283 3-Amino-chromanes and Tetrahydroquinolines as Selective 5-HTEBI University of Minnesota Twin Cities
26590100 42 Discovery of benzamides as potent human ?3 adrenergic receptor agonists.EBI Merck And
21170122 84 Comparative 3D QSAR study on ?(1)-, ?(2)-, and ?(3)-adrenoceptor agonists.EBI National Institute of Pharmaceutical Education and Research
21075638 105 Synthesis and pharmacological properties of novel hydrophilic 5-HT4 receptor antagonists.EBI Drug Discovery Laboratory
17560786 48 Synthesis and evaluation of potent and selective beta3 adrenergic receptor agonists containing heterobiaryl carboxylic acids.EBI Glaxosmithkline
10377236 15 2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists.EBI University of Tennessee
29751236 46 Synthesis and biological evaluation of ?EBI Shenyang Pharmaceutical University
30389290 146 Analogs of penfluridol as chemotherapeutic agents with reduced central nervous system activity.EBI Texas Tech University Health Sciences Center
29574204 54 Design and synthesis of aryloxypropanolamine as ?EBI East China Normal University
29767967 74 Structure-Guided Modification of Heterocyclic Antagonists of the P2YEBI National Institute of Diabetes and Digestive and Kidney Diseases
28355078 34 Discovery of Novel Indazole Derivatives as Orally Available?EBI Asahi Kasei Pharma
27128689 28 Deazaflavin Inhibitors of Tyrosyl-DNA Phosphodiesterase 2 (TDP2) Specific for the Human Enzyme and Active against Cellular TDP2.BDB National Institutes of Health
2172674 5 Amplification of the rat M2 muscarinic receptor gene by the polymerase chain reaction: functional expression of the M2 muscarinic receptor.BDB University of Arizona