51 articles for thisTarget

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The following articles (labelled with PubMed ID or TBD) are for your review

PMID	Data	Article Title	Organization
27131990	59	Discovery of 3-aminopicolinamides as metabotropic glutamate receptor subtype 4 (mGlu4) positive allosteric modulator warheads engendering CNS exposure and in vivo efficacy.	Vanderbilt University Medical Center
26814576	146	New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III.	University of Copenhagen
26231155	53	Re-exploring the N-phenylpicolinamide derivatives to develop mGlu4 ligands with improved affinity and in vitro microsomal stability.	Massachusetts General Hospital
25958247	22	Synthesis and studies on the mGluR agonist activity of FAP4 stereoisomers.	Univ. Rouen
25330258	18	Radiosynthesis and evaluation of an 18F-labeled positron emission tomography (PET) radioligand for metabotropic glutamate receptor subtype 4 (mGlu4).	Massachusetts General Hospital
24914612	36	Tetrahydronaphthyridine and dihydronaphthyridinone ethers as positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5).	Vanderbilt University Medical Center
24735492	98	Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): pharmacological characterization and assessment in a rat model of cocaine dependence.	Sanford-Burnham Medical Research Institute
23009245	53	Orally active metabotropic glutamate subtype 2 receptor positive allosteric modulators: structure-activity relationships and assessment in a rat model of nicotine dependence.	Sanford-Burnham Medical Research Institute
22750138	8	¿-amino-ß-fluorocyclopropanecarboxylic acids as a new tool for drug development: synthesis of glutamic acid analogs and agonist activity towards metabotropic glutamate receptor 4.	Insa De Rouen and Universit£
21247167	57	Discovery, synthesis, and structure-activity relationship development of a series of N-(4-acetamido)phenylpicolinamides as positive allosteric modulators of metabotropic glutamate receptor 4 (mGlu(4)) with CNS exposure in rats.	Vanderbilt University Medical Center
20218620	81	A virtual screening hit reveals new possibilities for developing group III metabotropic glutamate receptor agonists.	Universite Paris Descartes
18338843	57	Synthesis and pharmacological characterization at glutamate receptors of the four enantiopure isomers of tricholomic acid.	Universit£
17350267	48	Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2'-phosphono-3'-phenylcyclopropyl)glycine, the first class of 3'-substituted trans C1'-2'-2-(2'-phosphonocyclopropyl)glycines.	Universit£
16213710	32	Synthesis and preliminary biological evaluation of (2S,1'R,2'S)- and (2S,1'S,2'R)-2-(2'-phosphonocyclopropyl)glycines, two novel conformationally constrained l-AP4 analogues.	Universit£
15801843	16	Virtual screening workflow development guided by the"receiver operating characteristic" curve approach. Application to high-throughput docking on metabotropic glutamate receptor subtype 4.	Universit£
9357538	38	(S)-homo-AMPA, a specific agonist at the mGlu6 subtype of metabotropic glutamic acid receptors.	Royal Danish School of Pharmacy
7738999	88	Metabotropic glutamate receptors: novel targets for drug development.	Cns Research
22030026	13	Synthesis and SAR of a novel metabotropic glutamate receptor 4 (mGlu4) antagonist: unexpected 'molecular switch' from a closely related mGlu4 positive allosteric modulator.	Vanderbilt University Medical Center
21966889	61	Discovery, synthesis, and structure-activity relationship development of a series of N-4-(2,5-dioxopyrrolidin-1-yl)phenylpicolinamides (VU0400195, ML182): characterization of a novel positive allosteric modulator of the metabotropic glutamate receptor 4 (mGlu(4)) with oral efficacy in an antiparkin	Vanderbilt University Medical Center
20638279	46	An orally bioavailable positive allosteric modulator of the mGlu4 receptor with efficacy in an animal model of motor dysfunction.	Evotec (Uk)
19469556	47	Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).	Vanderbilt University Medical Center
	10	Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)	TBA
17722902	16	L-(+)-2-Amino-4-thiophosphonobutyric acid (L-thioAP4), a new potent agonist of group III metabotropic glutamate receptors: increased distal acidity affords enhanced potency.	Université
17376693	36	Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.	The Danish University of Pharmaceutical Sciences
16828551	12	Design and synthesis of APTCs (aminopyrrolidinetricarboxylic acids): identification of a new group III metabotropic glutamate receptor selective agonist.	Faust Pharmaceuticals
16190758	30	Synthesis, binding affinity at glutamic acid receptors, neuroprotective effects, and molecular modeling investigation of novel dihydroisoxazole amino acids.	Università
15317467	105	Synthesis, in vitro pharmacology, structure-activity relationships, and pharmacokinetics of 3-alkoxy-2-amino-6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent and selective group II metabotropic glutamate receptor antagonists.	Taisho Pharmaceutical
14711315	72	(2S,1'S,2'R,3'R)-2-(2'-Carboxy-3'-hydroxymethylcyclopropyl) glycine is a highly potent group 2 and 3 metabotropic glutamate receptor agonist with oral activity.	Eli Lilly
14643338	124	Binding of beta-carbolines at 5-HT(2) serotonin receptors.	Virginia Commonwealth University
12825948	13	Synthesis and anticonvulsant activity of novel bicyclic acidic amino acids.	Università
12213064	33	Selective agonists at group II metabotropic glutamate receptors: synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid.	The Royal Danish School of Pharmacy
11831912	43	Selective antagonists at group I metabotropic glutamate receptors: synthesis and molecular pharmacology of 4-aryl-3-isoxazolol amino acids.	The Royal Danish School of Pharmacy
10866390	7	(+)-4-phosphonophenylglycine (PPG) a new group III selective metabotropic glutamate receptor agonist.	Novartis Pharma
31537424	24	Discovery of a novel 3,4-dimethylcinnoline carboxamide M	Vanderbilt University
9871596	4	alpha-substituted quisqualic acid analogs: new metabotropic glutamate receptor group II selective antagonists.	Georgetown University Medical Center
30350962	102	Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu	Vanderbilt University School of Medicine
30247901	143	Discovery, Structure-Activity Relationship, and Biological Characterization of a Novel Series of 6-((1 H-Pyrazolo[4,3- b]pyridin-3-yl)amino)-benzo[ d]isothiazole-3-carboxamides as Positive Allosteric Modulators of the Metabotropic Glutamate Receptor 4 (mGlu	Vanderbilt University
29397723	267	Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites.	University of Paris
28902994	55	Discovery, Structure-Activity Relationship, and Antiparkinsonian Effect of a Potent and Brain-Penetrant Chemical Series of Positive Allosteric Modulators of Metabotropic Glutamate Receptor 4.	Prexton Therapeutics
26010139	34	Synthesis and anticholinergic activity of 4-hydroxycoumarin derivatives containing substituted benzyl-1,2,3-triazole moiety.	Tehran University of Medical Sciences
24119291	26	Design, synthesis and biological evaluation of pazopanib derivatives as antitumor agents.	Shandong Institute of Pharmaceutical Industry
24119242	17	Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents.	Chengde Medical University