The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 26299827 |
43 |
Discovery of 5-substituted tetrahydronaphthalen-2yl-methyl with N-phenyl-N-(piperidin-4-yl)propionamide derivatives as potent opioid receptor ligands. |
University of Arizona |
| 26252963 |
15 |
Novel diazabicycloalkane delta opioid agonists. |
Istituto Di Farmacologia Traslazionale |
| 25283554 |
43 |
Design, synthesis, and structure-activity relationship of novel opioid¿ receptor selective agonists:a-iminoamide derivatives with an azabicyclo[2.2.2]octene skeleton. |
Kitasato University |
| 25147605 |
52 |
Synthesis and Pharmacology of a Novel¿ Opioid Receptor (KOR) Agonist with a 1,3,5-Trioxazatriquinane Skeleton. |
Kitasato University |
| 25783191 |
87 |
Design, syntheses, and pharmacological characterization of 17-cyclopropylmethyl-3,14ß-dihydroxy-4,5a-epoxy-6a-(isoquinoline-3'-carboxamido)morphinan analogues as opioid receptor ligands. |
Virginia Commonwealth University |
| 25562563 |
18 |
Methoxyflavones from Stachys glutinosa with binding affinity to opioid receptors: in silico, in vitro, and in vivo studies. |
National Research Council |
| 25248680 |
67 |
Synthesis of a novel universal opioid receptor agonist with the 1,3,5-trioxazatriquinane skeleton and its pharmacologies. |
Kitasato University |
| 24900842 |
71 |
Novel delta opioid receptor agonists with oxazatricyclodecane structure. |
Kitasato University |
| 23477419 |
64 |
Design, synthesis, and pharmacological characterization of novel endomorphin-1 analogues as extremely potentµ-opioid agonists. |
Lanzhou University |
| 23200250 |
36 |
The effect of 17-N substituents on the activity of the opioid¿ receptor in nalfurafine derivatives. |
Kitasato University |
| 23131341 |
50 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. 3: synthesis of novel triplet drugs with the bis(epoxymethano) or bis(dimethylepoxymethano) structure (double-capped triplet). |
Kitasato University |
| 23103094 |
39 |
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 3: synthesis of decahydro(iminoethano)phenanthrene derivatives with an oxygen functionality at the 3-position and their pharmacologies. |
Kitasato University |
| 22734622 |
78 |
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associatedµ opioid receptor (MOR-1) splice variants. |
Memorial Sloan-Kettering Cancer Center |
| 23585918 |
16 |
Tuned-Affinity Bivalent Ligands for the Characterization of Opioid Receptor Heteromers. |
TBA |
| 22967810 |
102 |
Synthesis of quinolinomorphinan derivatives as highly selectived opioid receptor ligands. |
Kitasato University |
| 22742909 |
24 |
Essential structure of opioid¿ receptor agonist nalfurafine for binding to the¿ receptor 2: synthesis of decahydro(iminoethano)phenanthrene derivatives and their pharmacologies. |
Kitasato University |
| 22460026 |
39 |
Synthesis of new opioid derivatives with a propellane skeleton and their pharmacology. Part 2: Propellane derivatives with an amide side chain. |
Kitasato University |
| 22445285 |
26 |
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton and their pharmacologies. |
Kitasato University |
| 18990576 |
11 |
Synthesis of a novel 6,14-epoxymorphinan derivative and its pharmacology. |
Kitasato University |
| 18337104 |
7 |
Syntheses of 4,6'-epoxymorphinan derivatives and their pharmacologies. |
Kitasato University |
| 17962026 |
3 |
The influence of esters and carboxylic acids as the N-substituent of opioids. Part 1: Benzomorphans. |
University of Maryland |
| 18062664 |
13 |
Endomorphin-2 with a beta-turn backbone constraint retains the potent micro-opioid receptor agonist properties. |
Biological Research Center of The Hungarian Academy of Sciences |
| 15780604 |
2 |
18F-labeled sufentanil for PET-imaging of mu-opioid receptors. |
Technische Universit£T M£Nchen |
| 9397176 |
28 |
Cyclic enkephalin analogues with exceptional potency and selectivity for delta-opioid receptors. |
University of Arizona |
| 9379438 |
31 |
Discovery of a novel class of substituted pyrrolooctahydroisoquinolines as potent and selective delta opioid agonists, based on an extension of the message-address concept. |
Smithkline Beecham |
| 9207938 |
15 |
Pyrrolomorphinans as delta opioid receptor antagonists. The role of steric hindrance in conferring selectivity. |
University of Minnesota |
| 9171881 |
17 |
7-Spiroindanyl derivatives of naltrexone and oxymorphone as selective ligands for delta opioid receptors. |
University of Minnesota |
| 7932569 |
116 |
Antipodal alpha-N-(methyl through decyl)-N-normetazocines (5,9 alpha-dimethyl-2'-hydroxy-6,7-benzomorphans): in vitro and in vivo properties. |
Virginia Commonwealth University |
| 8246236 |
6 |
Possible contribution of a glutathione conjugate to the long-duration action of beta-funaltrexamine. |
University of Minnesota |
| 2549247 |
39 |
Benzofuro[2,3-c]pyridin-6-ols: synthesis, affinity for opioid-receptor subtypes, and antinociceptive activity. |
Ciba-Geigy |
| 6296388 |
68 |
Synthesis and pharmacological characterization in vitro of cyclic enkephalin analogues: effect of conformational constraints on opiate receptor selectivity. |
TBA |
| 9873568 |
22 |
Selective alpha-1a adrenergic receptor antagonists. Effects of pharmacophore regio- and stereochemistry on potency and selectivity. |
Merck |
| | 36 |
Pyrrolooctahydroisoquinolines as potent and selective opioid receptor ligands: SAR analysis and docking studies |
TBA |
| 22197670 |
51 |
Synthesis of quinolinomorphinan-4-ol derivatives asd opioid receptor agonists. |
Kitasato University |
| 21889335 |
27 |
Synthesis of novel triplet drugs with 1,3,5-trioxazatriquinane skeletons and their pharmacologies. Part 2: Synthesis of novel triplet drugs with the epoxymethano structure (capped homotriplet). |
Kitasato University |
| 20850307 |
27 |
Design and synthesis of KNT-127, ad-opioid receptor agonist effective by systemic administration. |
Kitasato University |
| 20413312 |
17 |
Synthesis and opioid activity of novel 6-substituted-6-demethoxy-ethenomorphinans. |
University of Debrecen |
| 19646882 |
72 |
Novel delta opioid receptor agonists exhibit differential stimulation of signaling pathways. |
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School and The Informatics Institute of Umdnj |
| 15857130 |
37 |
Ligand-based prediction of active conformation by 3D-QSAR flexibility descriptors and their application in 3+3D-QSAR models. |
University of Szeged |
| 15482911 |
65 |
Parallel methods for the preparation and SAR exploration of N-ethyl-4-[(8-alkyl-8-aza-bicyclo[3.2.1]oct-3-ylidene)-aryl-methyl]-benzamides, powerful mu and delta opioid agonists. |
Johnson and Johnson Pharmaceutical Research and Development |
| 14736254 |
70 |
Structure-activity study on the Phe side chain arrangement of endomorphins using conformationally constrained analogues. |
Biological Research Center of The Hungarian Academy of Sciences |
| 12408719 |
21 |
Synthesis and structure-activity relationships of an orally available and long-acting analgesic peptide, N(alpha)-amidino-Tyr-D-Arg-Phe-MebetaAla-OH (ADAMB). |
Daiichi Fine Chemical |
| 11150174 |
84 |
Synthesis and in vitro and in vivo activity of (-)-(1R,5R,9R)- and (+)-(1S,5S,9S)-N-alkenyl-, -N-alkynyl-, and -N-cyanoalkyl-5, 9-dimethyl-2'-hydroxy-6,7-benzomorphan homologues. |
Virginia Commonwealth University |
| 27556704 |
64 |
Mitragynine/Corynantheidine Pseudoindoxyls As Opioid Analgesics with Mu Agonism and Delta Antagonism, Which Do Not Recruit ?-Arrestin-2. |
Memorial Sloan Kettering Cancer Center |
| 10639279 |
26 |
Exploring the structure-activity relationships of [1-(4-tert-butyl-3'-hydroxy)benzhydryl-4-benzylpiperazine] (SL-3111), a high-affinity and selective delta-opioid receptor nonpeptide agonist ligand. |
The University of Arizona |
| 10579841 |
113 |
Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-methoxycarbonyl-4-phenylpiperidine moiety. |
Synaptic Pharmaceutical |
| 9986710 |
28 |
Dermorphin and deltorphin glycosylated analogues: synthesis and antinociceptive activity after systemic administration. |
Sapienza University of Rome |
| 30608693 |
48 |
Design, Synthesis, and Biological Evaluation of the Third Generation 17-Cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-[(4'-pyridyl)carboxamido]morphinan (NAP) Derivatives as ?/? Opioid Receptor Dual Selective Ligands. |
Virginia Commonwealth University |
| 9301669 |
24 |
7-spirobenzocyclohexyl derivatives of naltrexone, oxymorphone, and hydromorphone as selective opioid receptor ligands. |
University of Minnesota |
| 31782922 |
107 |
Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators. |
Virginia Commonwealth University |
| 8254604 |
50 |
Phe3-substituted analogues of deltorphin C. Spatial conformation and topography of the aromatic ring in peptide recognition by delta opioid receptors. |
University of Ferrara |
| 24262888 |
105 |
The most effective influence of 17-(3-ethoxypropyl) substituent on the binding affinity and the agonistic activity in KNT-127 derivatives, ? opioid receptor agonists. |
Kitasato University |
| 24095014 |
52 |
N-Alkyl dien- and trienamides from the roots of Otanthus maritimus with binding affinity for opioid and cannabinoid receptors. |
Uos of Cagliari |
| 24103580 |
36 |
Novel 6?-acylaminomorphinans with analgesic activity. |
Semmelweis University |
| 24090913 |
42 |
Synthesis and biological evaluation of novel delta (?) opioid receptor ligands with diazatricyclodecane skeletons. |
C.N.R. Istituto Di Farmacologia Traslazionale |
| 23948248 |
52 |
Structure activity relationship studies of 17-cyclopropylmethyl-3,14?-dihydroxy-4,5?-epoxy-6?-(isoquinoline-3'-carboxamido)morphinan (NAQ) analogues as potent opioid receptor ligands: preliminary results on the role of electronic characteristics for affinity and function. |
Virginia Commonwealth University |
| 23880538 |
51 |
Access to 7?-analogs of codeine with mixed ?/? agonist activity via 6,7-?-epoxide opening. |
University of Texas At Austin |
| 7932577 |
24 |
Selective kappa-opioid agonists: synthesis and structure-activity relationships of piperidines incorporating on oxo-containing acyl group. |
Smithkline Beecham Farmaceutici |
| 23623711 |
82 |
Design and synthesis of novel opioid ligands with an azabicyclo[2.2.2]octane skeleton having a 7-amide side chain and their pharmacologies. |
Kitasato University |
| 7658453 |
16 |
Stereoisomers of N-[1-hydroxy-(2-phenylethyl)-3-methyl-4-piperidyl]- N-phenylpropanamide: synthesis, stereochemistry, analgesic activity, and opioid receptor binding characteristics. |
Institute of Materia Medica |
| 6313921 |
10 |
Synthesis and pharmacological characterization of (+/-)-5,9 alpha-dimethyl-2-[2-(4-fluorophenyl)ethyl]-2'-hydroxy-6,7-benzomorphan (fluorophen), a ligand suitable for visualization of opiate receptors in vivo. |
TBA |
| 6090663 |
1 |
Design and synthesis of naltrexone-derived affinity labels with nonequilibrium opioid agonist and antagonist activities. Evidence for the existence of different mu receptor subtypes in different tissues. |
TBA |
| 29152051 |
40 |
?-Space Screening of Dermorphin-Based Tetrapeptides through Use of Constrained Arylazepinone and Quinolinone Scaffolds. |
Vrije Universiteit Brussel |
| 29853330 |
106 |
Chemical space screening around Phe |
Vrije Universiteit Brussel |
| 28522254 |
42 |
Novel delta opioid receptor agonists with oxazatricyclodecane structure showing potent agonistic activities. |
Kitasato University |
| 1648141 |
21 |
Naphtho and benzo analogues of the kappa opioid agonist trans-(+/-)-3,4-dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl] benzeneacetamide. |
University of Notre Dame |
| 26520885 |
21 |
Synthesis of 4-thiazolidinone analogs as potent in vitro anti-urease agents. |
Hazara University |
| 25996453 |
4 |
Synthesis of novel 3-aryl-1-oxa-2,8-diazaspiro[4.5]dec-2-ene derivatives and their biological evaluation against protein tyrosine phosphatase 1B. |
Jiangnan University |
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