The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 3488405 |
12 |
Synthesis and antiinflammatory/analgesic activities of 11H-dibenzo[b, e,][1,4]dioxepinacetic acids. |
TBA |
| 27131067 |
24 |
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR. |
Beni-Suef University |
| 27325447 |
6 |
Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells. |
Tohoku Medical and Pharmaceutical University |
| 27344214 |
16 |
Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies. |
King Saud University |
| 26999325 |
30 |
Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies. |
King Saud University |
| 27025563 |
12 |
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives. |
University of Mansoura |
| 26455657 |
12 |
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties. |
Tohoku Pharmaceutical University |
| 26197159 |
1 |
Synthesis of new 4-phenylpyrimidine-2(1H)-thiones and their potency to inhibit COX-1 and COX-2. |
University of Graz |
| 26117820 |
18 |
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents. |
Indian Institute of Technology (Banaras Hindu University) |
| 25768707 |
17 |
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model. |
Universit£ |
| 25549551 |
66 |
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities. |
King Saud University |
| 25147154 |
18 |
Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity. |
Dokki |
| 24576797 |
8 |
Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents. |
National Research Centre, Dokki |
| 25462246 |
20 |
Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents. |
Anadolu University |
| 25444084 |
40 |
Synthesis of novel pyrazole?thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors. |
Kle University |
| 25219899 |
16 |
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors. |
National Institute of Pharmaceutical Education and Research |
| 24763362 |
22 |
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors. |
National Institute of Pharmaceutical Education and Research |
| 24751552 |
20 |
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents. |
K.L.E.U'S College of Pharmacy |
| 24631365 |
10 |
Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents. |
Cairo University |
| 23043222 |
125 |
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor. |
Istituto Italiano Di Tecnologia |
| 22916727 |
18 |
Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity. |
Hokkaido University |
| 21800856 |
50 |
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro. |
University of Innsbruck |
| 22091869 |
6 |
Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR. |
Faculdade De Ci�Ncias E Tecnologia-Unl |
| 22516672 |
47 |
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2. |
University of Mansoura |
| 19880317 |
50 |
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans. |
Universidad Nacional De Colombia |
| 9461647 |
7 |
Two new isoflavones from Ceiba pentandra and their effect on cyclooxygenase-catalyzed prostaglandin biosynthesis. |
Uppsala University |
| 9461646 |
20 |
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis. |
Uppsala University |
| 18272371 |
50 |
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors. |
Temple University |
| 18023187 |
32 |
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers. |
University of Alberta |
| 18096394 |
22 |
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies. |
University of Alberta |
| 16143531 |
58 |
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases. |
University of Alberta |
| 15780608 |
12 |
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents. |
National Institute of Pharmaceutical Education and Research (NIPER) |
| | 35 |
Antiinflammatory -benzeneethanamines. III |
TBA |
| 22019186 |
6 |
Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents. |
Jamia Hamdard (Hamdard University) |
| 21890358 |
30 |
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors. |
University of Alberta |
| 19447036 |
12 |
Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. |
Shahid Beheshti University (M.C) |
| 21570309 |
42 |
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study. |
University of Mansoura |
| 21388719 |
54 |
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study. |
King Saud University |
| 21349729 |
44 |
Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase. |
Sun Yat-Sen University |
| 21144750 |
30 |
Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors. |
Nanjing University |
| 20961090 |
6 |
Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2. |
Tokushima Bunri University |
| 20727750 |
9 |
Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors. |
University of Alberta |
| 20804197 |
40 |
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones. |
Universitat De Barcelona |
| 20691338 |
24 |
Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors. |
Shahid Beheshti University of Medical Sciences |
| 20692174 |
12 |
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors. |
Gazi University |
| 20387815 |
40 |
Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation. |
Guru Nanak Dev University |
| 20236826 |
6 |
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro. |
University of Graz |
| 20045320 |
14 |
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. |
University of Alberta |
| 20061161 |
12 |
Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors. |
Shahid Beheshti University Mc |
| 19560931 |
15 |
Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors. |
Shahid Beheshti University (M.C) |
| 19457595 |
12 |
Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents. |
Hamdard University |
| 19481465 |
31 |
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation. |
Karl-Franzens-Universit£T Graz |
| 19596198 |
14 |
Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors. |
Shahid Beheshti University (M.C) |
| 19419861 |
18 |
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies. |
University of Alberta |
| 19136259 |
14 |
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. |
University of Alberta |
| 19084295 |
5 |
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors. |
Gazi University |
| 18945614 |
8 |
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity. |
University of Alberta |
| 18930406 |
12 |
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies. |
University of Alberta |
| 18835505 |
15 |
Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors. |
Guru Nanak Dev University |
| 11421736 |
31 |
Cox-2 inhibitory effects of naturally occurring and modified fatty acids. |
Uppsala University |
| 18226898 |
12 |
Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors. |
Shaheed Beheshti University of Medical Sciences |
| 18061444 |
7 |
1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities. |
Guru Nanak Dev University |
| 17937989 |
6 |
Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: a novel class of cyclooxygenase-2 inhibitors. |
The University of The West Indies |
| 17764958 |
18 |
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies. |
University of Alberta |
| 17509888 |
12 |
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies. |
National Cancer Institute At Frederick |
| 17079150 |
14 |
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors. |
Okayama University Graduate School of Medicine |
| 17067801 |
14 |
Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity. |
University of Alberta Edmonton |
| 16814546 |
41 |
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides. |
National Research Institute of Chinese Medicine |
| 15943479 |
18 |
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies. |
University of Alberta |
| 15603969 |
40 |
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme. |
University of Alberta |
| 15537365 |
20 |
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors. |
University of Alberta |
| 15341950 |
14 |
A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors. |
University of Alberta |
| 15267236 |
72 |
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors. |
University of Alberta |
| 15177458 |
11 |
Synthesis and anti-inflammatory effects of novel pimarane diterpenoid analogs. |
Seoul National University |
| 15050636 |
14 |
Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor. |
University of Alberta |
| 15050635 |
18 |
Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors. |
University of Alberta |
| 15013005 |
4 |
Synthesis and evaluation of S-4-(3-thienyl)phenyl-alpha-methylacetic acid. |
National Institute of Pharmaceutical Education and Research |
| 12798335 |
22 |
6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors. |
University of Alberta |
| 11909713 |
42 |
Thalidomide and its analogues as cyclooxygenase inhibitors. |
The University of Tokyo |
| 11714595 |
43 |
Discovery of a N'-hydroxyphenylformamidine derivative HET0016 as a potent and selective 20-HETE synthase inhibitor. |
Taisho Pharmaceutical |
| 32503692 |
2 |
Synthesis of novel 3,5,6-trisubstituted 2-pyridone derivatives and evaluation for their anti-inflammatory activity. |
Universidade Estadual De Maring£ |
| 32278513 |
8 |
Screening of chalcone analogs with anti-depressant, anti-inflammatory, analgesic, and COX-2-inhibiting effects. |
China-Japan Union Hospital of Jilin University |
| 11229771 |
38 |
Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship. |
Seoul National University |
| 32163284 |
1 |
Anti-inflammatory Metabolites from |
Korea University |
| 27658794 |
5 |
Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents. |
Shandong University of Technology |
| 31255927 |
34 |
Human disorders associated with inflammation and the evolving role of natural products to overcome. |
University of Delhi |
| 30909021 |
21 |
Insights into the chemistry and therapeutic potential of furanones: A versatile pharmacophore. |
Jamia Hamdard |
| 30928709 |
30 |
Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors. |
Al-Azhar University |
| 30771604 |
75 |
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase. |
Alexandria University |
| 9484493 |
11 |
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid. |
Oxis International |
| 31401465 |
52 |
Multi-target-directed-ligands acting as enzyme inhibitors and receptor ligands. |
Julius Maximilian University of W£Rzburg |
| 30469039 |
15 |
Anti-inflammatory activity of triazine derivatives: A systematic review. |
Universidad Tecnol£Gica De Pereira |
| 30396033 |
33 |
Medicinal chemistry of vicinal diaryl scaffold: A mini review. |
The M.S University of Baroda |
| 24531199 |
16 |
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles. |
University of Bari "A. Moro |
| 8246226 |
89 |
Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors. |
Ciba-Geigy |
| 24361187 |
12 |
Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors. |
Mazandaran University of Medical Sciences |
| 23769654 |
24 |
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors. |
Kurukshetra University |
| 23914900 |
8 |
Rotenoids from Boerhaavia diffusa as potential anti-inflammatory agents. |
National Institute of Pharmaceutical Education and Research (NIPER) |
| 23693150 |
4 |
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity. |
Jamia Hamdard (Hamdard University) |
| 23517721 |
8 |
Novel dual cyclooxygenase and lipoxygenase inhibitors targeting hyaluronan-CD44v6 pathway and inducing cytotoxicity in colon cancer cells. |
Medical University of South Carolina |
| 23528298 |
64 |
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2. |
King Saud University |
| 19303782 |
40 |
Phenolic compounds with radical scavenging and cyclooxygenase-2 (COX-2) inhibitory activities from Dioscorea opposita. |
Seoul National University |
| 3930740 |
60 |
Selective thromboxane synthetase inhibitors. 1. 1-[(Aryloxy)alkyl]-1H-imidazoles. |
TBA |
| 30216848 |
30 |
Structural alterations based on naproxen scaffold: Synthesis, evaluation of antitumor activity and COX-2 inhibition, and molecular docking. |
Mansoura University |
| 29207335 |
6 |
Tamoxifen a pioneering drug: An update on the therapeutic potential of tamoxifen derivatives. |
American University of Ras Al Khaimah |
| 29980364 |
28 |
Synthesis and biological properties of aryl methyl sulfones. |
Universitat De Barcelona |
| 3081722 |
47 |
Selective thromboxane synthetase inhibitors. 2. 3-(1H-imidazol-1-ylmethyl)-2-methyl-1H-indole-1-propanoic acid and analogues. |
TBA |
| 28710965 |
4 |
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6). |
Thomas Jefferson University |
| 2115589 |
22 |
Antiinflammatory agents. 4. Syntheses and biological evaluation of potential prodrugs of 2-amino-3-benzoylbenzeneacetic acid and 2-amino-3-(4-chlorobenzoyl)benzeneacetic acid. |
A.H. Robins |
| 28610982 |
6 |
Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides. |
Zhejiang Ocean University Engineering Technology Research Center of Marine Biomedical Products |
| 21774747 |
6 |
Biotransformation of dehydroepiandrosterone with Macrophomina phaseolina and ß-glucuronidase inhibitory activity of transformed products. |
University of Karachi |
| 21699374 |
15 |
Effects of dopaminergic compounds on carbonic anhydrase isozymes I, II, and VI. |
Agri Ibrahim Cecen University |
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