The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
27287367 |
36 |
Evaluation of bisbenzamidines as inhibitors for matriptase-2. |
University of Bonn |
27015008 |
51 |
Atropisomer Control in Macrocyclic Factor VIIa Inhibitors. |
Bristol-Myers Squibb Research & Development |
26985294 |
114 |
Design and Synthesis of Nonpeptide Inhibitors of Hepatocyte Growth Factor Activation. |
Southern Research |
27073051 |
71 |
Orally bioavailable pyridine and pyrimidine-based Factor XIa inhibitors: Discovery of the methyl N-phenyl carbamate P2 prime group. |
Bristol-Myers Squibb |
26732532 |
69 |
Active site-directed plasmin inhibitors: Extension on the P2 residue. |
Kobe Gakuin University |
26704266 |
80 |
Novel phenylalanine derived diamides as Factor XIa inhibitors. |
Bristol-Myers Squibb |
26421993 |
44 |
Structure-guided discovery of 2-aryl/pyridin-2-yl-1H-indole derivatives as potent and selective hepsin inhibitors. |
Aurigene Discovery Technologies |
26367391 |
6 |
Phenylalanine and Phenylglycine Analogues as Arginine Mimetics in Dengue Protease Inhibitors. |
Heidelberg University |
26393374 |
34 |
Improving the Selectivity of Engineered Protease Inhibitors: Optimizing the P2 Prime Residue Using a Versatile Cyclic Peptide Library. |
Queensland University of Technology |
26114810 |
8 |
Synthesis of 3,4-diaminobenzoyl derivatives as factor Xa inhibitors. |
Southeast University |
26122211 |
3 |
Discovery of non-competitive thrombin inhibitor derived from competitive tryptase inhibitor skeleton: Shift in molecular recognition resulted from skeletal conversion of carboxylate into phosphonate. |
Tokyo University of Pharmacy and Life Sciences |
25592713 |
37 |
Pyridine and pyridinone-based factor XIa inhibitors. |
Bristol-Myers Squibb |
26151189 |
56 |
Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors. |
TBA |
26005539 |
23 |
Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety. |
Bristol-Myers Squibb |
25782055 |
9 |
Discovery of a Cyclic Boronic Acidß-Lactamase Inhibitor (RPX7009) with Utility vs Class A Serine Carbapenemases. |
Rempex Pharmaceuticals |
25881820 |
62 |
Design and synthesis of potent, selective phenylimidazole-based FVIIa inhibitors. |
Bristol-Myers Squibb R & D |
25728130 |
79 |
Structure-based design of inhibitors of coagulation factor XIa with novel P1 moieties. |
Bristol-Myers Squibb |
24951330 |
25 |
Orally bioavailable factor Xa inhibitors containing alpha-substituted gem-dimethyl P4 moieties. |
Bristol-Myers Squibb |
25523211 |
18 |
Identification of potent orally active factor Xa inhibitors based on conjugation strategy and application of predictable fragment recommender system. |
Astellas Pharma |
25438755 |
9 |
Novel strategy to boost oral anticoagulant activity of blood coagulation enzyme inhibitors based on biotransformation into hydrophilic conjugates. |
Astellas Pharma |
25405503 |
109 |
Phenylimidazoles as potent and selective inhibitors of coagulation factor XIa with in vivo antithrombotic activity. |
Bristol-Myers Squibb |
25179681 |
81 |
Design, synthesis, and structure-activity and structure-pharmacokinetic relationship studies of novel [6,6,5] tricyclic fused oxazolidinones leading to the discovery of a potent, selective, and orally bioavailable FXa inhibitor. |
Chinese Academy of Sciences |
12565961 |
177 |
Structure-activity relationships of substituted benzothiophene-anthranilamide factor Xa inhibitors. |
Berlex Biosciences |
22726924 |
14 |
Discovery of benzothiazole guanidines as novel inhibitors of thrombin and trypsin IV. |
Astrazeneca |
12930148 |
41 |
Potent, small-molecule inhibitors of human mast cell tryptase. Antiasthmatic action of a dipeptide-based transition-state analogue containing a benzothiazole ketone. |
Johnson & Johnson Pharmaceutical Research & Development |
10956211 |
14 |
GRID/CPCA: a new computational tool to design selective ligands. |
Boehringer Ingelheim Pharma |
11858993 |
60 |
Novel, potent non-covalent thrombin inhibitors incorporating p(3)-lactam scaffolds. |
Corvas International |
16759084 |
12 |
Isatin compounds as noncovalent SARS coronavirus 3C-like protease inhibitors. |
Peking University |
15341970 |
59 |
P4 and P1' optimization of bicycloproline P2 bearing tetrapeptidyl alpha-ketoamides as HCV protease inhibitors. |
Eli Lilly |
15203158 |
84 |
Halothiophene benzimidazoles as P1 surrogates of inhibitors of blood coagulation factor Xa. |
Merck |
12482415 |
30 |
Small, low nanomolar, noncovalent thrombin inhibitors lacking a group to fill the 'distal binding pocket'. |
Merck Research Laboratories |
11549459 |
5 |
Synthesis and evaluation of the sunflower derived trypsin inhibitor as a potent inhibitor of the type II transmembrane serine protease, matriptase. |
National Cancer Institute-Frederick |
11425524 |
62 |
Dibasic inhibitors of human mast cell tryptase. Part 3: identification of a series of potent and selective inhibitors containing the benzamidine functionality. |
Axys Pharmaceuticals |
32340773 |
110 |
Design and synthesis of novel proline based factor XIa selective inhibitors as leads for potential new anticoagulants. |
Merck |
32605372 |
92 |
A New Class of Dengue and West Nile Virus Protease Inhibitors with Submicromolar Activity in Reporter Gene DENV-2 Protease and Viral Replication Assays. |
Heidelberg University |
32150407 |
27 |
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-?-lactamases. |
Qpex Biopharma |
11266160 |
57 |
Synthesis and SAR of benzamidine factor Xa inhibitors containing a vicinally-substituted heterocyclic core. |
Dupont Pharmaceuticals |
11212109 |
14 |
The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase. |
Roche Discover Welwyn |
27434175 |
54 |
Substrate-Guided Design of Selective FXIIa Inhibitors Based on the Plant-Derived Momordica cochinchinensis Trypsin Inhibitor-II (MCoTI-II) Scaffold. |
The University of Queensland |
27280436 |
304 |
Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines. |
Philipps University Marburg |
31679971 |
44 |
6-Substituted amiloride derivatives as inhibitors of the urokinase-type plasminogen activator for use in metastatic disease. |
University of Wollongong |
31445854 |
43 |
Structure based design of macrocyclic factor XIa inhibitors: Discovery of cyclic P1 linker moieties with improved oral bioavailability. |
Bristol-Myers Squibb |
31395511 |
29 |
Structure-activity analysis of peptidic Chlamydia HtrA inhibitors. |
University of Otago |
30446438 |
36 |
Design, synthesis and biological evaluation of anthranilamide derivatives as potential factor Xa (fXa) inhibitors. |
China Pharmaceutical University |
9873692 |
54 |
Preparation of meta-amidino-N,N-disubstituted anilines as potent inhibitors of coagulation factor Xa. |
Dupont Pharmaceuticals |
31833761 |
32 |
Potent, Orally Bioavailable, and Efficacious Macrocyclic Inhibitors of Factor XIa. Discovery of Pyridine-Based Macrocycles Possessing Phenylazole Carboxamide P1 Groups. |
Bristol-Myers Squibb |
9871573 |
15 |
Discovery of LB30057, a benzamidrazone-based selective oral thrombin inhibitor. |
Biotech Research Institute |
30830783 |
13 |
Potential Anticancer Agents Characterized from Selected Tropical Plants. |
The Ohio State University |
31103899 |
15 |
Synthesis and structure-activity relationships of small-molecular di-basic esters, amides and carbamates as flaviviral protease inhibitors. |
Heidelberg University |
30613336 |
32 |
Potent, Selective, and Cell-Penetrating Inhibitors of Kallikrein-Related Peptidase 4 Based on the Cyclic Peptide MCoTI-II. |
The University of Queensland |
30833107 |
18 |
3-Acyltetramic acids as a novel class of inhibitors for human kallikreins 5 and 7. |
Universidade Federal Fluminense |
31563807 |
63 |
Discovery of novel, potent, isosteviol-based antithrombotic agents. |
Peking University |
31413811 |
26 |
Iterative Optimization of the Cyclic Peptide SFTI-1 Yields Potent Inhibitors of Neutrophil Proteinase 3. |
The University of Queensland |
24261937 |
6 |
Protease inhibitors from Microcystis aeruginosa bloom material collected from the Dalton Reservoir, Israel. |
Tel-Aviv University |
23777401 |
4 |
Aeruginosins from a Microcystis sp. bloom material collected in Varanasi, India. |
Tel-Aviv University |
23718637 |
1 |
Metabolites from Microcystis aeruginosa bloom material collected at a water reservoir near Kibbutz Hafetz Haim, Israel. |
Tel-Aviv University |
21506603 |
4 |
HCV-NS3/4A protease inhibitory iridoid glucosides and dimeric foliamenthoic acid derivatives from Anarrhinum orientale. |
Cairo University |
9214730 |
9 |
Effects of flavonoids isolated from scutellariae radix on fibrinolytic system induced by trypsin in human umbilical vein endothelial cells. |
Ehime University |
17350836 |
5 |
Synthesis of fluorescent-labeled aeruginosin derivatives for high-throughput fluorescence correlation spectroscopy assays. |
Graduate School of Science and Engineering |
29072911 |
16 |
Design of Small-Molecule Active-Site Inhibitors of the S1A Family Proteases as Procoagulant and Anticoagulant Drugs. |
University of Nottingham |
29550094 |
28 |
Structure-based drug design of 1,3,6-trisubstituted 1,4-diazepan-7-ones as selective human kallikrein 7 inhibitors. |
Asubio Pharma |
29501396 |
59 |
Pyridazine and pyridazinone derivatives as potent and selective factor XIa inhibitors. |
Bristol-Myers Squibb |
30212625 |
107 |
Depsipeptides Featuring a Neutral P1 Are Potent Inhibitors of Kallikrein-Related Peptidase 6 with On-Target Cellular Activity. |
German Cancer Research Center (Dkfz) |
30130401 |
71 |
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer. |
University of Wollongong |
29775297 |
7 |
Factor XIa Inhibitors as New Anticoagulants. |
Bristol-Myers Squibb |
29407959 |
82 |
The selectivity and bioavailability improvement of novel oral anticoagulants: An overview. |
Hefei University of Technology |
29102227 |
19 |
Discovery and structure-activity relationship study of 1,3,6-trisubstituted 1,4-diazepane-7-ones as novel human kallikrein 7 inhibitors. |
Asubio Pharma |
29936356 |
27 |
Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. |
The University of Queensland |
29808677 |
5 |
Jizanpeptins, Cyanobacterial Protease Inhibitors from a Symploca sp. Cyanobacterium Collected in the Red Sea. |
Oregon State University |