The following articles (labelled with PubMed ID or TBD) are for your review
PMID | Data | Article Title | Organization |
28105277 |
33 |
Design and Synthesis of Novel Meta-Linked Phenylglycine Macrocyclic FVIIa Inhibitors. |
Bristol-Myers Squibb |
27994741 |
48 |
Discovery of Phenylglycine Lactams as Potent Neutral Factor VIIa Inhibitors. |
Bristol-Myers Squibb R & D |
27612545 |
37 |
Synthesis and P1' SAR exploration of potent macrocyclic tissue factor-factor VIIa inhibitors. |
Bristol-Myers Squibb Research & Development |
27455395 |
66 |
Discovery of a Highly Potent, Selective, and Orally Bioavailable Macrocyclic Inhibitor of Blood Coagulation Factor VIIa-Tissue Factor Complex. |
Bristol-Myers Squibb R & D |
27015008 |
51 |
Atropisomer Control in Macrocyclic Factor VIIa Inhibitors. |
Bristol-Myers Squibb Research & Development |
26200936 |
39 |
Applications of Fluorine in Medicinal Chemistry. |
Bristol-Myers Squibb Research and Development |
26151189 |
56 |
Structure-Based Design of Macrocyclic Coagulation Factor VIIa Inhibitors. |
TBA |
23845220 |
53 |
Nonbenzamidine acylsulfonamide tissue factor-factor VIIa inhibitors. |
Bristol-Myers Squibb R & D |
16289811 |
56 |
The discovery of fluoropyridine-based inhibitors of the factor VIIa/TF complex--Part 2. |
Pfizer |
19483697 |
23 |
Phage-encoded combinatorial chemical libraries based on bicyclic peptides. |
Laboratory of Molecular Biology, Medical Research Council |
20650636 |
118 |
Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate. |
F. Hoffmann-La Roche |
17064913 |
29 |
Design, synthesis and biological activity of selective and orally available TF/FVIIa complex inhibitors containing non-amidine P1 ligands. |
Astellas Pharma |
16793264 |
13 |
Potent 4-amino-5-azaindole factor VIIa inhibitors. |
Celera Genomics |
16455251 |
11 |
Factor VIIa inhibitors: improved pharmacokinetic parameters. |
Celera Genomics |
16412633 |
9 |
Factor VIIa inhibitors: chemical optimization, preclinical pharmacokinetics, pharmacodynamics, and efficacy in an arterial baboon thrombosis model. |
Celera Genomics |
16125385 |
55 |
The discovery of fluoropyridine-based inhibitors of the Factor VIIa/TF complex. |
Pfizer |
11527709 |
19 |
Optimization of a screening lead for factor VIIa/TF. |
Axys Pharmaceuticals |
25764119 |
15 |
Discovery of novel P1 groups for coagulation factor VIIa inhibition using fragment-based screening. |
Bristol-Myers Squibb |
29072911 |
16 |
Design of Small-Molecule Active-Site Inhibitors of the S1A Family Proteases as Procoagulant and Anticoagulant Drugs. |
University of Nottingham |
29407959 |
82 |
The selectivity and bioavailability improvement of novel oral anticoagulants: An overview. |
Hefei University of Technology |