The following articles (labelled with PubMed ID or TBD) are for your review
| PMID | Data | Article Title | Organization |
|---|
| 28105280 |
39 |
GluN2A-Selective Pyridopyrimidinone Series of NMDAR Positive Allosteric Modulators with an Improved |
Genentech |
| 26919761 |
107 |
Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. |
Pharmaron-Beijing |
| 26653877 |
47 |
Studies on Aryl-Substituted Phenylalanines: Synthesis, Activity, and Different Binding Modes at AMPA Receptors. |
University of Copenhagen |
| 25375781 |
4 |
Positive allosteric modulators of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid receptors belonging to 4-cyclopropyl-3,4-dihydro-2h-1,2,4-pyridothiadiazine dioxides and diversely chloro-substituted 4-cyclopropyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxides. |
University of Liege |
| 23432124 |
2 |
Studies on an (S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid (AMPA) receptor antagonist IKM-159: asymmetric synthesis, neuroactivity, and structural characterization. |
Yokohama City University |
| 21190850 |
25 |
Structure based evolution of a novel series of positive modulators of the AMPA receptor. |
Merck Research Laboratories |
| 20408529 |
32 |
4-hydroxy-1,2,5-oxadiazol-3-yl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and molecular pharmacological characterization at ionotropic glutamate receptors of compounds related to glutamate and its homologues. |
Universit£ |
| 18269227 |
14 |
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4-hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. |
University of Copenhagen |
| 17672447 |
25 |
Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA. |
University of Copenhagen |
| 17348638 |
25 |
Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists. |
University Walk |
| 12238915 |
18 |
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine. |
Eli Lilly |
| 9357531 |
58 |
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes. |
University of Bristol |
| 10969973 |
103 |
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists. |
Eli Lilly |
| 21923187 |
5 |
A new phenylalanine derivative acts as an antagonist at the AMPA receptor GluA2 and introduces partial domain closure: synthesis, resolution, pharmacology, and crystal structure. |
University of Copenhagen |
| 21067182 |
37 |
Biostructural and Pharmacological Studies of Bicyclic Analogues of the 3-Isoxazolol Glutamate Receptor Agonist Ibotenic Acid |
TBA |
| 20971003 |
50 |
N-substituted pyrrolidines and tetrahydrofurans as novel AMPAR positive modulators. |
Glaxosmithkline |
| 20839777 |
25 |
Positive allosteric modulators of thea-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor. |
Merck Research Laboratories |
| 20356304 |
9 |
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside. |
Novartis Pharma |
| 20096591 |
84 |
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands. |
University of California |
| 18754610 |
2 |
6-Azido-7-nitro-1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. |
University of California San Francisco |
| 16879964 |
60 |
A novel class of AMPA receptor allosteric modulators. Part 1: design, synthesis, and SAR of 3-aryl-4-cyano-5-substituted-heteroaryl-2-carboxylic acid derivatives. |
Eli Lilly |
| 16872827 |
97 |
A novel class of positive allosteric modulators of AMPA receptors: design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346. |
Eli Lilly |
| 16610801 |
34 |
Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists. |
University Walk |
| 15974569 |
21 |
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain. |
Eli Lilly |
| 15857151 |
37 |
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues. |
The Danish University of Pharmaceutical Sciences |
| 14667236 |
61 |
2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. |
The Danish University of Pharmaceutical Sciences |
| 12747796 |
39 |
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO). |
The Danish University of Pharmaceutical Sciences |
| 10821708 |
138 |
4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists. |
Eli Lilly |
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