Found 21 hits for monomerid = 50029150 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| 1.72 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McNeil Pharmaceutical
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 247: 1032-8 (1988)
BindingDB Entry DOI: 10.7270/Q2S75DV7 |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Siena
Curated by ChEMBL
| Assay Description Effect of compound on Serotonin transporter uptake from rat cortex using [3H]citalopram as radioligand |
J Med Chem 38: 2692-704 (1995)
BindingDB Entry DOI: 10.7270/Q27H1K7H |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| 2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma
Curated by ChEMBL
| Assay Description In vitro inhibitory constant against [3H]-paroxetine binding to rat frontal cortex membrane serotonin reuptake site |
J Med Chem 48: 6855-69 (2005)
Article DOI: 10.1021/jm050148z BindingDB Entry DOI: 10.7270/Q21C1WFP |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| 2.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma
Curated by ChEMBL
| Assay Description In vitro binding affinity for serotonin reuptake sites in rat frontal cortex membranes by [3H]-paroxetine displacement. |
Bioorg Med Chem Lett 13: 405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2Z89BSX |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| Article PubMed
| 5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by PDSP Ki Database
| |
Eur J Pharmacol 349: 129-32 (1998)
Article DOI: 10.1016/s0014-2999(98)00241-6 BindingDB Entry DOI: 10.7270/Q279436B |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
Reactome pathway KEGG
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| 50.2 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McNeil Pharmaceutical
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 247: 1032-8 (1988)
BindingDB Entry DOI: 10.7270/Q2S75DV7 |
More data for this Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | GoogleScholar AffyNet
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Patents
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| PubMed
| 513 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McNeil Pharmaceutical
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 247: 1032-8 (1988)
BindingDB Entry DOI: 10.7270/Q2S75DV7 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 2A
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| PubMed
| 794 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 5: 43-7 (1991)
BindingDB Entry DOI: 10.7270/Q2RN36B3 |
More data for this Ligand-Target Pair | |
D(2) dopamine receptor
(Homo sapiens (Human)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
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| >1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Solvay Pharma
Curated by ChEMBL
| Assay Description In vitro binding affinity at human cloned dopamine receptor D2 (long) stably expressed in CHO cells by [3H]-Spiperone displacement. |
Bioorg Med Chem Lett 13: 405-8 (2003)
BindingDB Entry DOI: 10.7270/Q2Z89BSX |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | Reactome pathway KEGG
UniProtKB/SwissProt
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| 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McNeil Pharmaceutical
Curated by PDSP Ki Database
| |
J Pharmacol Exp Ther 247: 1032-8 (1988)
BindingDB Entry DOI: 10.7270/Q2S75DV7 |
More data for this Ligand-Target Pair | |
Norepinephrine transporter
(RAT) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | GoogleScholar AffyNet
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| Article PubMed
| 2.76E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
McGill University
Curated by PDSP Ki Database
| |
Eur J Pharmacol 349: 129-32 (1998)
Article DOI: 10.1016/s0014-2999(98)00241-6 BindingDB Entry DOI: 10.7270/Q279436B |
More data for this Ligand-Target Pair | |
Serotonin (5-HT) receptor
(RAT) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| 3.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 5: 43-7 (1991)
BindingDB Entry DOI: 10.7270/Q2RN36B3 |
More data for this Ligand-Target Pair | |
HTR2C
(Beef) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
UniProtKB/SwissProt
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| 3.24E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 5: 43-7 (1991)
BindingDB Entry DOI: 10.7270/Q2RN36B3 |
More data for this Ligand-Target Pair | |
HTR1D
(Bos taurus (Bovine)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | Reactome pathway
UniProtKB/TrEMBL
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| 3.63E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 5: 43-7 (1991)
BindingDB Entry DOI: 10.7270/Q2RN36B3 |
More data for this Ligand-Target Pair | |
Serotonin 1B/1D receptor
(Rattus norvegicus (Rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
Reactome pathway KEGG
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| 4.47E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 5: 43-7 (1991)
BindingDB Entry DOI: 10.7270/Q2RN36B3 |
More data for this Ligand-Target Pair | |
5-hydroxytryptamine receptor 1A
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| 9.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Eli Lilly and Company
Curated by PDSP Ki Database
| |
Neuropsychopharmacology 5: 43-7 (1991)
BindingDB Entry DOI: 10.7270/Q2RN36B3 |
More data for this Ligand-Target Pair | |
Norepinephrine Monoamine transporters
(Rattus norvegicus) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | Reactome pathway KEGG
UniProtKB/TrEMBL
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| n/a | n/a | 1.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of uptake of noradrenaline in rat brain hypothalamus |
J Med Chem 23: 1306-10 (1981)
BindingDB Entry DOI: 10.7270/Q2GT5NQD |
More data for this Ligand-Target Pair | |
Sodium-dependent dopamine transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | Reactome pathway KEGG
UniProtKB/SwissProt
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| n/a | n/a | 1.80E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of uptake of dopamine (DA) rat brain striatum |
J Med Chem 23: 1306-10 (1981)
BindingDB Entry DOI: 10.7270/Q2GT5NQD |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Rattus norvegicus (rat)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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| PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibition of uptake of 5-HT in rat brain cortex |
J Med Chem 23: 1306-10 (1981)
BindingDB Entry DOI: 10.7270/Q2GT5NQD |
More data for this Ligand-Target Pair | |
Sodium-dependent serotonin transporter
(Homo sapiens (Human)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
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DrugBank antibodypedia GoogleScholar AffyNet
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| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description In vivo inhibition of uptake of 5-HT in human platelets |
J Med Chem 23: 1306-10 (1981)
BindingDB Entry DOI: 10.7270/Q2GT5NQD |
More data for this Ligand-Target Pair | |
Bile salt export pump
(Homo sapiens (Human)) | BDBM50029150
(3-(2-Piperidin-4-yl-ethyl)-1H-indole | CHEMBL27652...)Show InChI InChI=1S/C15H20N2/c1-2-4-15-14(3-1)13(11-17-15)6-5-12-7-9-16-10-8-12/h1-4,11-12,16-17H,5-10H2 | PDB
UniProtKB/SwissProt
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| Article PubMed
| n/a | n/a | >1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-... |
Drug Metab Dispos 40: 2332-41 (2012)
Article DOI: 10.1124/dmd.112.047068 BindingDB Entry DOI: 10.7270/Q2ZP488M |
More data for this Ligand-Target Pair | |