Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM19428![]() ((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus after 10 mins by fluorimetric analysis | Bioorg Med Chem Lett 19: 5684-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.010 BindingDB Entry DOI: 10.7270/Q2NZ87QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM50277188![]() (CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant C-terminal FLAG-tagged HDAC1 expressed in baculovirus by fluorimetry | Bioorg Med Chem Lett 19: 336-40 (2008) Article DOI: 10.1016/j.bmcl.2008.11.081 BindingDB Entry DOI: 10.7270/Q2416WXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24496![]() (3-(3-fluoro-4-{[2-(pyrrolidin-1-ylcarbonyl)thieno[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50277188![]() (CHEMBL473270 | N1-(biphenyl-3-yl)-N8-hydroxyoctane...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetry | Bioorg Med Chem Lett 19: 336-40 (2008) Article DOI: 10.1016/j.bmcl.2008.11.081 BindingDB Entry DOI: 10.7270/Q2416WXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24500![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-2-yl)thien...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50255853![]() (4-(((R)-2,3-dihydro-2-oxo-3-phenethylquinoxalin-4(...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM19130![]() ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 2 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50255852![]() (4-(((R)-3-(4-hydroxybenzyl)-2,3-dihydro-2-oxoquino...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24498![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50255096![]() (4-(((R)-3-benzyl-2,3-dihydro-2-oxoquinoxalin-4(1H)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 2 (Homo sapiens (Human)) | BDBM19428![]() ((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of recombinant C-terminal FLAG-tagged HDAC2 expressed in baculovirus after 10 mins by fluorimetric analysis | Bioorg Med Chem Lett 19: 5684-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.010 BindingDB Entry DOI: 10.7270/Q2NZ87QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24499![]() (3-(4-{[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24505![]() (3-(3-fluoro-4-{[2-(pyridin-2-yl)thieno[3,2-b]pyrid...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24504![]() (3-(3-fluoro-4-{[2-(1,3-thiazol-2-yl)thieno[3,2-b]p...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24493![]() (7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM19130![]() ((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL MMDB PC cid PC sid PDB UniChem Patents Similars | PDB Article PubMed | n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24502![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)thieno...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 24 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24502![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-pyrazol-4-yl)thieno...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24501![]() (3-(4-{[2-(1-ethyl-1H-imidazol-2-yl)thieno[3,2-b]py...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24503![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-1,2,4-triazol-5-yl)...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24498![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-4-yl)thien...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 29 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24510![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-pyrrol-2-yl)thieno[...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 31 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24485![]() (3-{4-[(6,7-dimethoxyquinolin-4-yl)oxy]-3-fluorophe...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Vascular endothelial growth factor receptor 2 (Homo sapiens (Human)) | BDBM24509![]() (3-(3-fluoro-4-{[2-(thiophen-2-yl)thieno[3,2-b]pyri...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50255809![]() (4-(((R)-3-(3,4-difluorobenzyl)-2,3-dihydro-2-oxoqu...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50255854![]() ((R)-tert-butyl 4-(1-(4-(hydroxycarbamoyl)benzyl)-3...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50255914![]() (4-(((R)-2,3-dihydro-2-oxo-3-((thiophen-2-yl)methyl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24493![]() (7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 48 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24510![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-pyrrol-2-yl)thieno[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 49 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 7 (Homo sapiens (Human)) | BDBM50300446![]() (CHEMBL583490 | N-hydroxy-9H-xanthene-9-carboxamide) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | Purchase CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal FLAG-tagged HDAC7 (438-915) expressed in baculovirus after 10 mins by fluorimetric analysis | Bioorg Med Chem Lett 19: 5684-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.010 BindingDB Entry DOI: 10.7270/Q2NZ87QH | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50255910![]() (4-(((R)-3-(4-tert-butoxybenzyl)-2,3-dihydro-2-oxoq...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 50 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant histone deacetylase 6 | Bioorg Med Chem Lett 19: 688-92 (2009) Article DOI: 10.1016/j.bmcl.2008.12.045 BindingDB Entry DOI: 10.7270/Q2G44Q5S | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24500![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-imidazol-2-yl)thien...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 51 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24499![]() (3-(4-{[2-(1-ethyl-1H-imidazol-4-yl)thieno[3,2-b]py...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 52 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24496![]() (3-(3-fluoro-4-{[2-(pyrrolidin-1-ylcarbonyl)thieno[...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 54 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-arginine methyltransferase CARM1 (Mus musculus (mouse)) | BDBM27642![]() (1-(5-{[(2S)-2-aminopropanamido]methyl}thiophen-3-y...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 9.0 | 22 |
MethylGene Inc. | Assay Description Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor... | Bioorg Med Chem Lett 19: 1218-23 (2009) Article DOI: 10.1016/j.bmcl.2008.12.075 BindingDB Entry DOI: 10.7270/Q2K64GC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 6 (Homo sapiens (Human)) | BDBM50277329![]() ((S)-benzyl 1-(6-methoxyquinolin-8-ylamino)-1-oxo-6...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal histidine-tagged HDAC6 expressed in baculovirus by fluorimetry | Bioorg Med Chem Lett 19: 336-40 (2008) Article DOI: 10.1016/j.bmcl.2008.11.081 BindingDB Entry DOI: 10.7270/Q2416WXB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-arginine methyltransferase CARM1 (Mus musculus (mouse)) | BDBM27641![]() (1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 9.0 | 22 |
MethylGene Inc. | Assay Description Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor... | Bioorg Med Chem Lett 19: 1218-23 (2009) Article DOI: 10.1016/j.bmcl.2008.12.075 BindingDB Entry DOI: 10.7270/Q2K64GC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24508![]() (3-(3-fluoro-4-{[2-(1,3,4-thiadiazol-2-yl)thieno[3,...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-arginine methyltransferase CARM1 (Mus musculus (mouse)) | BDBM27641![]() (1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-[(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | KEGG PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc Curated by ChEMBL | Assay Description Inhibition of N-terminal His-tagged mouse recombinant CARM1 expressed in Sf9 cells by microbeta counting | Bioorg Med Chem Lett 19: 6725-32 (2009) Article DOI: 10.1016/j.bmcl.2009.09.110 BindingDB Entry DOI: 10.7270/Q20P104P | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24505![]() (3-(3-fluoro-4-{[2-(pyridin-2-yl)thieno[3,2-b]pyrid...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 62 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24512![]() (3-(3-fluoro-4-{[2-(pyrimidin-5-yl)thieno[3,2-b]pyr...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 63 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 1 (Homo sapiens (Human)) | BDBM50257130![]() ((S)-2-(2-(5-methoxy-2-methyl-1H-indol-3-yl)acetami...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 64 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant FLAG-tagged HDAC1 expressed in baculovirus | Bioorg Med Chem Lett 19: 1866-70 (2009) Article DOI: 10.1016/j.bmcl.2009.02.075 BindingDB Entry DOI: 10.7270/Q2PV6K7W | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24504![]() (3-(3-fluoro-4-{[2-(1,3-thiazol-2-yl)thieno[3,2-b]p...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24491![]() (7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 65 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24503![]() (3-(3-fluoro-4-{[2-(1-methyl-1H-1,2,4-triazol-5-yl)...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 69 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24509![]() (3-(3-fluoro-4-{[2-(thiophen-2-yl)thieno[3,2-b]pyri...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24511![]() (3-(3-fluoro-4-{[2-(furan-3-yl)thieno[3,2-b]pyridin...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 74 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-arginine methyltransferase CARM1 (Mus musculus (mouse)) | BDBM27659![]() (1-(3-{[(2S)-2-aminopropanamido]methyl}phenyl)-N-be...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet ![]() | CHEMBL KEGG PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | 9.0 | 22 |
MethylGene Inc. | Assay Description Histone H3 is used as the substrate for CARM-1 enzyme, and the methylation is monitored using tritiated S-Adenosyl-Methionine (SAM) as a methyl donor... | Bioorg Med Chem Lett 19: 1218-23 (2009) Article DOI: 10.1016/j.bmcl.2008.12.075 BindingDB Entry DOI: 10.7270/Q2K64GC6 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hepatocyte growth factor receptor (Homo sapiens (Human)) | BDBM24492![]() (7-(2-fluoro-4-{[(1-phenylacetamido)methanethioyl]a...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 80 | n/a | n/a | n/a | n/a | 7.5 | 30 |
MethylGene Inc. | Assay Description Inhibition of kinase activity was measured in a DELFIA assay (Perkin-Elmer). The substrate poly (Glu4, Tyr) was immobilized onto black high-binding p... | Bioorg Med Chem Lett 18: 2793-8 (2008) Article DOI: 10.1016/j.bmcl.2008.04.009 BindingDB Entry DOI: 10.7270/Q25X2778 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 5 (Homo sapiens (Human)) | BDBM50300443![]() (2,2-bis(3-fluorophenyl)-N-hydroxyacetamide | CHEMB...) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet ![]() | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc. Curated by ChEMBL | Assay Description Inhibition of human recombinant N-terminal FLAG-tagged HDAC5 (620-1122) expressed in baculovirus after 10 mins by fluorimetric analysis | Bioorg Med Chem Lett 19: 5684-8 (2009) Article DOI: 10.1016/j.bmcl.2009.08.010 BindingDB Entry DOI: 10.7270/Q2NZ87QH | |||||||||||
More data for this Ligand-Target Pair |
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