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Compile Data Set for Download or QSAR

Found 76 hits with Last Name = 'penhallow' and Initial = 'ba'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092365
PNG
((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1
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n/an/a 1.35n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092366
PNG
(3-Benzyl-4-(2-dimethylamino-ethanesulfonyl)-1-(3H-...)
Show SMILES CN(C)CCS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C25H30N6O2S/c1-29(2)10-11-34(32,33)31-16-22-12-21(14-26)8-9-25(22)30(17-23-15-27-19-28-23)18-24(31)13-20-6-4-3-5-7-20/h3-9,12,15,19,24H,10-11,13,16-18H2,1-2H3,(H,27,28)/t24-/m1/s1
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n/an/a 1.53n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092363
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-(propane-1-s...)
Show SMILES CCCS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C24H27N5O2S/c1-2-10-32(30,31)29-15-21-11-20(13-25)8-9-24(21)28(16-22-14-26-18-27-22)17-23(29)12-19-6-4-3-5-7-19/h3-9,11,14,18,23H,2,10,12,15-17H2,1H3,(H,26,27)/t23-/m1/s1
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n/an/a 1.77n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092377
PNG
(4-Benzenesulfonyl-3-benzyl-1-(3H-imidazol-4-ylmeth...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1ccccc1
Show InChI InChI=1S/C27H25N5O2S/c28-15-22-11-12-27-23(13-22)17-32(35(33,34)26-9-5-2-6-10-26)25(14-21-7-3-1-4-8-21)19-31(27)18-24-16-29-20-30-24/h1-13,16,20,25H,14,17-19H2,(H,29,30)/t25-/m1/s1
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n/an/a 1.77n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092372
PNG
(3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,...)
Show SMILES CN(C)S(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C23H26N6O2S/c1-27(2)32(30,31)29-14-20-10-19(12-24)8-9-23(20)28(15-21-13-25-17-26-21)16-22(29)11-18-6-4-3-5-7-18/h3-10,13,17,22H,11,14-16H2,1-2H3,(H,25,26)/t22-/m1/s1
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n/an/a 2.85n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092357
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C22H23N5O2S/c1-30(28,29)27-13-19-9-18(11-23)7-8-22(19)26(14-20-12-24-16-25-20)15-21(27)10-17-5-3-2-4-6-17/h2-9,12,16,21H,10,13-15H2,1H3,(H,24,25)/t21-/m1/s1
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n/an/a 3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092375
PNG
(1-(3H-Imidazol-4-ylmethyl)-4-methanesulfonyl-7-phe...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1cccnc1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-13-22(21-7-3-2-4-8-21)9-10-26(23)30(17-24-15-28-19-29-24)18-25(31)12-20-6-5-11-27-14-20/h2-11,13-15,19,25H,12,16-18H2,1H3,(H,28,29)/t25-/m1/s1
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n/an/a 5.95n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092371
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1)-c1cccnc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-13-21(22-8-5-11-27-14-22)9-10-26(23)30(17-24-15-28-19-29-24)18-25(31)12-20-6-3-2-4-7-20/h2-11,13-15,19,25H,12,16-18H2,1H3,(H,28,29)
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n/an/a 7.90n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092361
PNG
(4-Acetyl-3-benzyl-1-(3H-imidazol-4-ylmethyl)-2,3,4...)
Show SMILES CC(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C23H23N5O/c1-17(29)28-13-20-9-19(11-24)7-8-23(20)27(14-21-12-25-16-26-21)15-22(28)10-18-5-3-2-4-6-18/h2-9,12,16,22H,10,13-15H2,1H3,(H,25,26)/t22-/m1/s1
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n/an/a 8.75n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092364
PNG
(3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-4-meth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1
Show InChI InChI=1S/C21H23BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h2-8,10-11,15,20H,9,12-14H2,1H3,(H,23,24)/t20-/m1/s1
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n/an/a 10.7n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092355
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)-c1ccncc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-14-22(21-9-11-27-12-10-21)7-8-26(23)30(17-24-15-28-19-29-24)18-25(31)13-20-5-3-2-4-6-20/h2-12,14-15,19,25H,13,16-18H2,1H3,(H,28,29)/t25-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092367
PNG
(3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,...)
Show SMILES CN(C)C(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C24H26N6O/c1-28(2)24(31)30-14-20-10-19(12-25)8-9-23(20)29(15-21-13-26-17-27-21)16-22(30)11-18-6-4-3-5-7-18/h3-10,13,17,22H,11,14-16H2,1-2H3,(H,26,27)/t22-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092368
PNG
(7-Bromo-3-(2-chloro-benzyl)-1-(3H-imidazol-4-ylmet...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1Cl
Show InChI InChI=1S/C21H22BrClN4O2S/c1-30(28,29)27-11-16-8-17(22)6-7-21(16)26(12-18-10-24-14-25-18)13-19(27)9-15-4-2-3-5-20(15)23/h2-8,10,14,19H,9,11-13H2,1H3,(H,24,25)
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n/an/a 18n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092373
PNG
(3-Benzyl-7-cyano-1-(3H-imidazol-4-ylmethyl)-1,2,3,...)
Show SMILES CCOC(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N
Show InChI InChI=1S/C24H25N5O2/c1-2-31-24(30)29-14-20-10-19(12-25)8-9-23(20)28(15-21-13-26-17-27-21)16-22(29)11-18-6-4-3-5-7-18/h3-10,13,17,22H,2,11,14-16H2,1H3,(H,26,27)/t22-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092356
PNG
(7-Bromo-3-cyclohexylmethyl-1-(3H-imidazol-4-ylmeth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)C[C@H]1CC1CCCCC1
Show InChI InChI=1S/C21H29BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h7-8,10-11,15-16,20H,2-6,9,12-14H2,1H3,(H,23,24)/t20-/m1/s1
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n/an/a 23.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092374
PNG
(7-Bromo-3-(3-chloro-benzyl)-1-(3H-imidazol-4-ylmet...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1cccc(Cl)c1
Show InChI InChI=1S/C21H22BrClN4O2S/c1-30(28,29)27-11-16-9-17(22)5-6-21(16)26(12-19-10-24-14-25-19)13-20(27)8-15-3-2-4-18(23)7-15/h2-7,9-10,14,20H,8,11-13H2,1H3,(H,24,25)
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n/an/a 24n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092378
PNG
(3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-4-meth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1
Show InChI InChI=1S/C21H23BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h2-8,10-11,15,20H,9,12-14H2,1H3,(H,23,24)
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n/an/a 30n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092369
PNG
(7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfon...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1CCc1ccccc1
Show InChI InChI=1S/C22H25BrN4O2S/c1-30(28,29)27-13-18-11-19(23)8-10-22(18)26(14-20-12-24-16-25-20)15-21(27)9-7-17-5-3-2-4-6-17/h2-6,8,10-12,16,21H,7,9,13-15H2,1H3,(H,24,25)
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n/an/a 45n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092370
PNG
(3-Benzyl-1-(3H-imidazol-4-ylmethyl)-4-methanesulfo...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H28N4O2S/c1-34(32,33)31-17-24-15-23(22-10-6-3-7-11-22)12-13-27(24)30(18-25-16-28-20-29-25)19-26(31)14-21-8-4-2-5-9-21/h2-13,15-16,20,26H,14,17-19H2,1H3,(H,28,29)
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n/an/a 54.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092381
PNG
(1-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-3-naphthalen...)
Show SMILES CC(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1cccc2ccccc12
Show InChI InChI=1S/C26H25BrN4O/c1-18(32)31-14-21-11-22(27)9-10-26(21)30(15-23-13-28-17-29-23)16-24(31)12-20-7-4-6-19-5-2-3-8-25(19)20/h2-11,13,17,24H,12,14-16H2,1H3,(H,28,29)
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n/an/a 54.5n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092362
PNG
(1-[3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-1,2...)
Show SMILES CC(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1
Show InChI InChI=1S/C22H23BrN4O/c1-16(28)27-12-18-10-19(23)7-8-22(18)26(13-20-11-24-15-25-20)14-21(27)9-17-5-3-2-4-6-17/h2-8,10-11,15,21H,9,12-14H2,1H3,(H,24,25)
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n/an/a 60n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092360
PNG
(CHEMBL119993 | N-[7-Bromo-1-(3H-imidazol-4-ylmethy...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1CNC(=O)c1ccccc1
Show InChI InChI=1S/C22H24BrN5O3S/c1-32(30,31)28-12-17-9-18(23)7-8-21(17)27(13-19-10-24-15-26-19)14-20(28)11-25-22(29)16-5-3-2-4-6-16/h2-10,15,20H,11-14H2,1H3,(H,24,26)(H,25,29)
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n/an/a 86n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092379
PNG
(7-Bromo-1-(3H-imidazol-4-ylmethyl)-4-methanesulfon...)
Show SMILES COc1ccc(CC2CN(Cc3cnc[nH]3)c3ccc(Br)cc3CN2S(C)(=O)=O)cc1
Show InChI InChI=1S/C22H25BrN4O3S/c1-30-21-6-3-16(4-7-21)9-20-14-26(13-19-11-24-15-25-19)22-8-5-18(23)10-17(22)12-27(20)31(2,28)29/h3-8,10-11,15,20H,9,12-14H2,1-2H3,(H,24,25)
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n/an/a 101n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083431
PNG
(CHEMBL121010 | [7-Bromo-1-(3H-imidazol-4-ylmethyl)...)
Show SMILES Brc1ccc2N(Cc3cnc[nH]3)CCN(Cc2c1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H21BrN4O/c25-19-8-9-23-18(12-19)14-29(11-10-28(23)15-20-13-26-16-27-20)24(30)22-7-3-5-17-4-1-2-6-21(17)22/h1-9,12-13,16H,10-11,14-15H2,(H,26,27)
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n/an/a 228n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092359
PNG
(CHEMBL118496 | [3-Benzyl-1-(3H-imidazol-4-ylmethyl...)
Show SMILES O=C(N1Cc2ccccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1)c1cccc2ccccc12
Show InChI InChI=1S/C31H28N4O/c36-31(29-15-8-13-24-11-4-6-14-28(24)29)35-19-25-12-5-7-16-30(25)34(20-26-18-32-22-33-26)21-27(35)17-23-9-2-1-3-10-23/h1-16,18,22,27H,17,19-21H2,(H,32,33)
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n/an/a 276n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083418
PNG
(Biphenyl-2-yl-[1-(3H-imidazol-4-ylmethyl)-1,2,3,5-...)
Show SMILES O=C(N1CCN(Cc2cnc[nH]2)c2ccccc2C1)c1ccccc1-c1ccccc1
Show InChI InChI=1S/C26H24N4O/c31-26(24-12-6-5-11-23(24)20-8-2-1-3-9-20)30-15-14-29(18-22-16-27-19-28-22)25-13-7-4-10-21(25)17-30/h1-13,16,19H,14-15,17-18H2,(H,27,28)
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n/an/a 320n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083419
PNG
(CHEMBL356840 | {1-[2-(1H-Imidazol-4-yl)-ethyl]-1,2...)
Show SMILES O=C(N1CCN(CCc2cnc[nH]2)c2ccccc2C1)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N4O/c30-25(23-10-5-8-19-6-1-3-9-22(19)23)29-15-14-28(13-12-21-16-26-18-27-21)24-11-4-2-7-20(24)17-29/h1-11,16,18H,12-15,17H2,(H,26,27)
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n/an/a 340n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092358
PNG
(1-(3H-Imidazol-4-ylmethyl)-4-methanesulfonyl-7-phe...)
Show SMILES CS(=O)(=O)N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccncc1)-c1ccccc1
Show InChI InChI=1S/C26H27N5O2S/c1-34(32,33)31-16-23-14-22(21-5-3-2-4-6-21)7-8-26(23)30(17-24-15-28-19-29-24)18-25(31)13-20-9-11-27-12-10-20/h2-12,14-15,19,25H,13,16-18H2,1H3,(H,28,29)/t25-/m1/s1
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n/an/a 383n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092376
PNG
(3-Benzyl-7-bromo-1-(3H-imidazol-4-ylmethyl)-4-meth...)
Show SMILES CS(=O)(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)C[C@@H]1Cc1ccccc1
Show InChI InChI=1S/C21H23BrN4O2S/c1-29(27,28)26-12-17-10-18(22)7-8-21(17)25(13-19-11-23-15-24-19)14-20(26)9-16-5-3-2-4-6-16/h2-8,10-11,15,20H,9,12-14H2,1H3,(H,23,24)/t20-/m0/s1
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n/an/a 437n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083439
PNG
(CHEMBL358680 | [1-(1H-Imidazol-4-ylmethyl)-1,2,3,5...)
Show SMILES O=C(N1CCN(Cc2cnc[nH]2)c2ccccc2C1)c1cccc2ccccc12
Show InChI InChI=1S/C24H22N4O/c29-24(22-10-5-8-18-6-1-3-9-21(18)22)28-13-12-27(16-20-14-25-17-26-20)23-11-4-2-7-19(23)15-28/h1-11,14,17H,12-13,15-16H2,(H,25,26)
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n/an/a 456n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083439
PNG
(CHEMBL358680 | [1-(1H-Imidazol-4-ylmethyl)-1,2,3,5...)
Show SMILES O=C(N1CCN(Cc2cnc[nH]2)c2ccccc2C1)c1cccc2ccccc12
Show InChI InChI=1S/C24H22N4O/c29-24(22-10-5-8-18-6-1-3-9-21(18)22)28-13-12-27(16-20-14-25-17-26-20)23-11-4-2-7-19(23)15-28/h1-11,14,17H,12-13,15-16H2,(H,25,26)
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n/an/a 460n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083422
PNG
(1-(3H-Imidazol-4-ylmethyl)-4-(naphthalene-1-sulfon...)
Show SMILES O=S(=O)(N1CCN(Cc2cnc[nH]2)c2ccccc2C1)c1cccc2ccccc12
Show InChI InChI=1S/C23H22N4O2S/c28-30(29,23-11-5-8-18-6-1-3-9-21(18)23)27-13-12-26(16-20-14-24-17-25-20)22-10-4-2-7-19(22)15-27/h1-11,14,17H,12-13,15-16H2,(H,24,25)
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n/an/a 480n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083433
PNG
(CHEMBL151851 | {1-[3-(1H-Imidazol-2-yl)-propyl]-1,...)
Show SMILES O=C(N1CCN(CCCc2ncc[nH]2)c2ccccc2C1)c1cccc2ccccc12
Show InChI InChI=1S/C26H26N4O/c31-26(23-11-5-9-20-7-1-3-10-22(20)23)30-18-17-29(16-6-13-25-27-14-15-28-25)24-12-4-2-8-21(24)19-30/h1-5,7-12,14-15H,6,13,16-19H2,(H,27,28)
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n/an/a 590n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083420
PNG
((2-Benzylamino-phenyl)-[1-(3H-imidazol-4-ylmethyl)...)
Show SMILES O=C(N1CCN(Cc2cnc[nH]2)c2ccccc2C1)c1ccccc1NCc1ccccc1
Show InChI InChI=1S/C27H27N5O/c33-27(24-11-5-6-12-25(24)29-16-21-8-2-1-3-9-21)32-15-14-31(19-23-17-28-20-30-23)26-13-7-4-10-22(26)18-32/h1-13,17,20,29H,14-16,18-19H2,(H,28,30)
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n/an/a 600n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083405
PNG
(1-[1-(3H-Imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-b...)
Show SMILES O=C(Cc1ccccc1Oc1ccccc1)N1CCN(Cc2cnc[nH]2)c2ccccc2C1
Show InChI InChI=1S/C27H26N4O2/c32-27(16-21-8-5-7-13-26(21)33-24-10-2-1-3-11-24)31-15-14-30(19-23-17-28-20-29-23)25-12-6-4-9-22(25)18-31/h1-13,17,20H,14-16,18-19H2,(H,28,29)
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n/an/a 700n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083445
PNG
(2-[1-(3H-Imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-b...)
Show SMILES COC(=O)c1ccccc1S(=O)(=O)N1CCN(Cc2cnc[nH]2)c2ccccc2C1
Show InChI InChI=1S/C21H22N4O4S/c1-29-21(26)18-7-3-5-9-20(18)30(27,28)25-11-10-24(14-17-12-22-15-23-17)19-8-4-2-6-16(19)13-25/h2-9,12,15H,10-11,13-14H2,1H3,(H,22,23)
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n/an/a 720n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083444
PNG
(CHEMBL357974 | [1-(2-Aminomethyl-3H-imidazol-4-ylm...)
Show SMILES NCc1ncc(CN2CCN(Cc3ccccc23)C(=O)c2cccc3ccccc23)[nH]1
Show InChI InChI=1S/C25H25N5O/c26-14-24-27-15-20(28-24)17-29-12-13-30(16-19-7-2-4-11-23(19)29)25(31)22-10-5-8-18-6-1-3-9-21(18)22/h1-11,15H,12-14,16-17,26H2,(H,27,28)
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n/an/a 840n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092380
PNG
(CHEMBL118896 | [1-(3H-Imidazol-4-ylmethyl)-3-methy...)
Show SMILES CC1CN(Cc2cnc[nH]2)c2ccccc2CN1C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C25H24N4O/c1-18-14-28(16-21-13-26-17-27-21)24-12-5-3-8-20(24)15-29(18)25(30)23-11-6-9-19-7-2-4-10-22(19)23/h2-13,17-18H,14-16H2,1H3,(H,26,27)
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083438
PNG
(CHEMBL424509 | [1-(3-Benzyl-3H-imidazol-4-ylmethyl...)
Show SMILES O=C(N1CCN(Cc2cncn2Cc2ccccc2)c2ccccc2C1)c1cccc2ccccc12
Show InChI InChI=1S/C31H28N4O/c36-31(29-15-8-13-25-11-4-6-14-28(25)29)34-18-17-33(30-16-7-5-12-26(30)21-34)22-27-19-32-23-35(27)20-24-9-2-1-3-10-24/h1-16,19,23H,17-18,20-22H2
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n/an/a 1.10E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083410
PNG
(1-(3H-Imidazol-4-ylmethyl)-1,2,3,5-tetrahydro-benz...)
Show SMILES O=C(N(c1ccccc1)c1ccccc1)N1CCN(Cc2cnc[nH]2)c2ccccc2C1
Show InChI InChI=1S/C26H25N5O/c32-26(31(23-10-3-1-4-11-23)24-12-5-2-6-13-24)30-16-15-29(19-22-17-27-20-28-22)25-14-8-7-9-21(25)18-30/h1-14,17,20H,15-16,18-19H2,(H,27,28)
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n/an/a 1.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092382
PNG
(1-[7-Bromo-1-(3H-imidazol-4-ylmethyl)-3-naphthalen...)
Show SMILES CC(=O)N1Cc2cc(Br)ccc2N(Cc2cnc[nH]2)CC1Cc1ccc2ccccc2c1
Show InChI InChI=1S/C26H25BrN4O/c1-18(32)31-14-22-12-23(27)8-9-26(22)30(15-24-13-28-17-29-24)16-25(31)11-19-6-7-20-4-2-3-5-21(20)10-19/h2-10,12-13,17,25H,11,14-16H2,1H3,(H,28,29)
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n/an/a 1.26E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))
BDBM50092365
PNG
((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of geranylgeranyl transferase (GGT1) using Ras-CVLL as substrate


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083430
PNG
(CHEMBL148816 | [(S)-4-(3H-Imidazol-4-ylmethyl)-3-(...)
Show SMILES COCC[C@H]1CN(CCN1Cc1cnc[nH]1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C22H26N4O2/c1-28-12-9-19-15-26(11-10-25(19)14-18-13-23-16-24-18)22(27)21-8-4-6-17-5-2-3-7-20(17)21/h2-8,13,16,19H,9-12,14-15H2,1H3,(H,23,24)/t19-/m0/s1
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50092383
PNG
(1-[3-Benzyl-1-(3H-imidazol-4-ylmethyl)-1,2,3,5-tet...)
Show SMILES CC(=O)N1Cc2ccccc2N(Cc2cnc[nH]2)CC1Cc1ccccc1
Show InChI InChI=1S/C22H24N4O/c1-17(27)26-13-19-9-5-6-10-22(19)25(14-20-12-23-16-24-20)15-21(26)11-18-7-3-2-4-8-18/h2-10,12,16,21H,11,13-15H2,1H3,(H,23,24)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of purified recombinant human farnesyltransferase (FT)


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083428
PNG
(CHEMBL348426 | {1-[2-(2-Amino-ethyl)-3H-imidazol-4...)
Show SMILES NCCc1ncc(CN2CCN(Cc3ccccc23)C(=O)c2cccc3ccccc23)[nH]1
Show InChI InChI=1S/C26H27N5O/c27-13-12-25-28-16-21(29-25)18-30-14-15-31(17-20-7-2-4-11-24(20)30)26(32)23-10-5-8-19-6-1-3-9-22(19)23/h1-11,16H,12-15,17-18,27H2,(H,28,29)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Geranylgeranyl transferase type-1 subunit beta/Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha


(Homo sapiens (Human))
BDBM50092365
PNG
((R)-1-((1H-imidazol-5-yl)methyl)-3-benzyl-4-(thiop...)
Show SMILES O=S(=O)(N1Cc2cc(ccc2N(Cc2cnc[nH]2)C[C@H]1Cc1ccccc1)C#N)c1cccs1
Show InChI InChI=1S/C25H23N5O2S2/c26-13-20-8-9-24-21(11-20)15-30(34(31,32)25-7-4-10-33-25)23(12-19-5-2-1-3-6-19)17-29(24)16-22-14-27-18-28-22/h1-11,14,18,23H,12,15-17H2,(H,27,28)/t23-/m1/s1
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n/an/a 2.30E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibition of geranylgeranyl transferase (GGT1) using K-Ras as substrate


J Med Chem 43: 3587-95 (2000)


BindingDB Entry DOI: 10.7270/Q2WD3ZSV
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083417
PNG
(CHEMBL151813 | [4-(1H-Imidazol-4-ylmethyl)-2,3,4,5...)
Show SMILES O=C(N1CCN(Cc2cnc[nH]2)Cc2ccccc12)c1cccc2ccccc12
Show InChI InChI=1S/C24H22N4O/c29-24(22-10-5-8-18-6-1-3-9-21(18)22)28-13-12-27(16-20-14-25-17-26-20)15-19-7-2-4-11-23(19)28/h1-11,14,17H,12-13,15-16H2,(H,25,26)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083412
PNG
(CHEMBL151902 | [(S)-4-[2-(3H-Imidazol-4-yl)-ethyl]...)
Show SMILES COCC[C@H]1CN(CCN1CCc1cnc[nH]1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C23H28N4O2/c1-29-14-10-20-16-27(13-12-26(20)11-9-19-15-24-17-25-19)23(28)22-8-4-6-18-5-2-3-7-21(18)22/h2-8,15,17,20H,9-14,16H2,1H3,(H,24,25)/t20-/m0/s1
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n/an/a 3.20E+3n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083435
PNG
(CHEMBL348672 | [(S)-4-[3-(3H-Imidazol-4-yl)-propyl...)
Show SMILES COCC[C@H]1CN(CCN1CCCc1cnc[nH]1)C(=O)c1cccc2ccccc12
Show InChI InChI=1S/C24H30N4O2/c1-30-15-11-21-17-28(14-13-27(21)12-5-8-20-16-25-18-26-20)24(29)23-10-4-7-19-6-2-3-9-22(19)23/h2-4,6-7,9-10,16,18,21H,5,8,11-15,17H2,1H3,(H,25,26)/t21-/m0/s1
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n/an/a 1.00E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
Dimer of Protein farnesyltransferase subunit beta


(Homo sapiens (Human))
BDBM50083409
PNG
(CHEMBL355971 | [1-(3H-Imidazol-4-ylmethyl)-7-pyrid...)
Show SMILES O=C(N1CCN(Cc2cnc[nH]2)c2ccc(cc2C1)-c1ccncc1)c1cccc2ccccc12
Show InChI InChI=1S/C29H25N5O/c35-29(27-7-3-5-22-4-1-2-6-26(22)27)34-15-14-33(19-25-17-31-20-32-25)28-9-8-23(16-24(28)18-34)21-10-12-30-13-11-21/h1-13,16-17,20H,14-15,18-19H2,(H,31,32)
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n/an/a 1.54E+4n/an/an/an/an/an/a



Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL


Assay Description
Inhibitory activity against human purified recombinant farnesyltransferase (hFT)


J Med Chem 42: 5241-53 (2000)


BindingDB Entry DOI: 10.7270/Q2GM86GZ
More data for this
Ligand-Target Pair
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