Found 437 hits with Last Name = 'pilorge' and Initial = 'f' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389047
(CHEMBL2064328)Show InChI InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50365890
(CHEMBL1957875)Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1 |r| Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389047
(CHEMBL2064328)Show InChI InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at T308 residue expressed in PTEN-deficient human PC3 cells after 2 hrs by Western blot ana... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389048
(CHEMBL2064417)Show SMILES Fc1ccc2oc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1-c1ccccc1 Show InChI InChI=1S/C22H19FN4O3/c23-15-6-7-16-22(21(15)14-4-2-1-3-5-14)26-20(30-16)12-17-24-18(13-19(28)25-17)27-8-10-29-11-9-27/h1-7,13H,8-12H2,(H,24,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449305
(CHEMBL3125379)Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1 Show InChI InChI=1S/C19H20ClN3O4S/c1-11-9-12-13(20)3-2-4-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-5-7-27-8-6-22/h2-4,11H,5-10H2,1H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389069
(CHEMBL2064344)Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H21N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h1-9,15H,10-14H2,(H,24,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389048
(CHEMBL2064417)Show SMILES Fc1ccc2oc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1-c1ccccc1 Show InChI InChI=1S/C22H19FN4O3/c23-15-6-7-16-22(21(15)14-4-2-1-3-5-14)26-20(30-16)12-17-24-18(13-19(28)25-17)27-8-10-29-11-9-27/h1-7,13H,8-12H2,(H,24,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389072
(CHEMBL2064341)Show SMILES Fc1ccc2n(C3CC3)c(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1 Show InChI InChI=1S/C19H20FN5O2/c20-12-1-4-15-14(9-12)21-18(25(15)13-2-3-13)10-16-22-17(11-19(26)23-16)24-5-7-27-8-6-24/h1,4,9,11,13H,2-3,5-8,10H2,(H,22,23,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50365890
(CHEMBL1957875)Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1 |r| Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389067
(CHEMBL2064346)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3[nH]2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H21N5O2/c28-21-14-20(27-9-11-29-12-10-27)24-19(25-21)13-18-23-17-8-4-7-16(22(17)26-18)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,26)(H,24,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449293
(CHEMBL3125394)Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1 Show InChI InChI=1S/C19H21ClN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 10 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50365890
(CHEMBL1957875)Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1 |r| Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in mouse MEF-3T3 cells after 0.5 to 2 hrs by Western blot analy... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449301
(CHEMBL3125383)Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1 Show InChI InChI=1S/C18H18BrN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449312
(CHEMBL3125390)Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1 Show InChI InChI=1S/C18H19BrN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 11 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449293
(CHEMBL3125394)Show SMILES CC1Cc2c(cccc2Cl)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1 Show InChI InChI=1S/C19H21ClN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 13 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449291
(CHEMBL3125375)Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1 Show InChI InChI=1S/C19H21FN4O3S/c1-11-8-12-9-13(20)2-3-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-4-6-27-7-5-23/h2-3,9,11H,4-8,10H2,1H3,(H2,21,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 14 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449296
(CHEMBL3125391)Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1 Show InChI InChI=1S/C18H19FN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449303
(CHEMBL3125381)Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(O)=O)N1CCOCC1 Show InChI InChI=1S/C19H20FN3O4S/c1-11-8-12-9-13(20)2-3-15(12)23(11)16(24)10-14-17(18(25)26)28-19(21-14)22-4-6-27-7-5-22/h2-3,9,11H,4-8,10H2,1H3,(H,25,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 15 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389041
(CHEMBL2064333)Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2cc(F)ccc12 Show InChI InChI=1S/C17H18FN5O2/c1-22-13-3-2-11(18)8-12(13)19-15(22)9-14-20-16(10-17(24)21-14)23-4-6-25-7-5-23/h2-3,8,10H,4-7,9H2,1H3,(H,20,21,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 16 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449292
(CHEMBL3125395)Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1 Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389065
(CHEMBL2064348)Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2cccc(-c3ccccc3)c12 Show InChI InChI=1S/C23H23N5O2/c1-27-20(14-19-25-21(15-22(29)26-19)28-10-12-30-13-11-28)24-18-9-5-8-17(23(18)27)16-6-3-2-4-7-16/h2-9,15H,10-14H2,1H3,(H,25,26,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449292
(CHEMBL3125395)Show SMILES CC1Cc2c(cccc2Br)N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1 Show InChI InChI=1S/C19H21BrN4O3S/c1-11-9-12-13(20)3-2-4-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-5-7-27-8-6-23/h2-4,11H,5-10H2,1H3,(H2,21,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 17 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389054
(CHEMBL2064411)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H20N4O3/c27-20-14-19(26-9-11-28-12-10-26)23-18(24-20)13-21-25-22-16(7-4-8-17(22)29-21)15-5-2-1-3-6-15/h1-8,14H,9-13H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 19 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449291
(CHEMBL3125375)Show SMILES CC1Cc2cc(F)ccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1 Show InChI InChI=1S/C19H21FN4O3S/c1-11-8-12-9-13(20)2-3-15(12)24(11)16(25)10-14-17(18(21)26)28-19(22-14)23-4-6-27-7-5-23/h2-3,9,11H,4-8,10H2,1H3,(H2,21,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50389070
(CHEMBL2064343)Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2C2CCCCC2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H27N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h4-5,8-9,15-16H,1-3,6-7,10-14H2,(H,24,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 21 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449296
(CHEMBL3125391)Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1 Show InChI InChI=1S/C18H19FN4O3S/c19-12-1-2-14-11(9-12)3-4-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-5-7-26-8-6-22/h1-2,9H,3-8,10H2,(H2,20,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449312
(CHEMBL3125390)Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Br)N1CCOCC1 Show InChI InChI=1S/C18H19BrN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389052
(CHEMBL2064413)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2cccs2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C20H18N4O3S/c25-18-12-17(24-6-8-26-9-7-24)21-16(22-18)11-19-23-20-13(15-5-2-10-28-15)3-1-4-14(20)27-19/h1-5,10,12H,6-9,11H2,(H,21,22,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449306
(CHEMBL3125378)Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2Cl)N1CCOCC1 Show InChI InChI=1S/C18H18ClN3O4S/c19-12-2-1-3-14-11(12)4-5-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-6-8-26-9-7-21/h1-3H,4-10H2,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 23 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449304
(CHEMBL3125380)Show SMILES OC(=O)c1sc(nc1CC(=O)N1CCc2cc(F)ccc12)N1CCOCC1 Show InChI InChI=1S/C18H18FN3O4S/c19-12-1-2-14-11(9-12)3-4-22(14)15(23)10-13-16(17(24)25)27-18(20-13)21-5-7-26-8-6-21/h1-2,9H,3-8,10H2,(H,24,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449300
(CHEMBL3125385)Show InChI InChI=1S/C18H20N4O3S/c19-17(24)16-13(20-18(26-16)21-7-9-25-10-8-21)11-15(23)22-6-5-12-3-1-2-4-14(12)22/h1-4H,5-11H2,(H2,19,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389062
(CHEMBL2064352)Show InChI InChI=1S/C16H15FN4O3/c17-10-1-2-12-11(7-10)18-16(24-12)8-13-19-14(9-15(22)20-13)21-3-5-23-6-4-21/h1-2,7,9H,3-6,8H2,(H,19,20,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389066
(CHEMBL2064347)Show SMILES Cn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2c(cccc12)-c1ccccc1 Show InChI InChI=1S/C23H23N5O2/c1-27-18-9-5-8-17(16-6-3-2-4-7-16)23(18)26-20(27)14-19-24-21(15-22(29)25-19)28-10-12-30-13-11-28/h2-9,15H,10-14H2,1H3,(H,24,25,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389073
(CHEMBL2064340)Show SMILES CCn1c(Cc2nc(cc(=O)[nH]2)N2CCOCC2)nc2ccccc12 Show InChI InChI=1S/C18H21N5O2/c1-2-23-14-6-4-3-5-13(14)19-17(23)11-15-20-16(12-18(24)21-15)22-7-9-25-10-8-22/h3-6,12H,2,7-11H2,1H3,(H,20,21,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 26 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389047
(CHEMBL2064328)Show InChI InChI=1S/C22H24N2O3/c1-15-12-18(16(2)23-17-6-4-3-5-7-17)22-19(13-15)20(25)14-21(27-22)24-8-10-26-11-9-24/h3-7,12-14,16,23H,8-11H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 28 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389072
(CHEMBL2064341)Show SMILES Fc1ccc2n(C3CC3)c(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1 Show InChI InChI=1S/C19H20FN5O2/c20-12-1-4-15-14(9-12)21-18(25(15)13-2-3-13)10-16-22-17(11-19(26)23-16)24-5-7-27-8-6-24/h1,4,9,11,13H,2-3,5-8,10H2,(H,22,23,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 29 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389042
(CHEMBL2064331)Show SMILES Fc1ccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)[nH]c2c1 Show InChI InChI=1S/C16H16FN5O2/c17-10-1-2-11-12(7-10)19-13(18-11)8-14-20-15(9-16(23)21-14)22-3-5-24-6-4-22/h1-2,7,9H,3-6,8H2,(H,18,19)(H,20,21,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Heat shock protein HSP 90-beta
(Homo sapiens (Human)) | BDBM50357454
(CHEMBL1917878)Show SMILES O=C(N[C@@H]1c2ccccc2-c2c1cccc2-c1nc2ccncc2[nH]1)c1ccnc2[nH]ccc12 |r| Show InChI InChI=1S/C27H18N6O/c34-27(18-9-13-30-25-17(18)8-12-29-25)33-24-16-5-2-1-4-15(16)23-19(24)6-3-7-20(23)26-31-21-10-11-28-14-22(21)32-26/h1-14,24H,(H,29,30)(H,31,32)(H,33,34)/t24-/m1/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| PDB Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi-Aventis Research and Development
Curated by ChEMBL
| Assay Description Inhibition of HSP90beta in human SKBR3 cells assessed as down regulation of HER2 expression levels after 24 hrs by FACS analysis |
J Med Chem 54: 7206-19 (2011)
Article DOI: 10.1021/jm200784m BindingDB Entry DOI: 10.7270/Q2QR4XH4 |
More data for this Ligand-Target Pair | 3D Structure (crystal) |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50365890
(CHEMBL1957875)Show SMILES C[C@@H](Nc1ccccc1)c1cc(C)cn2c1nc(cc2=O)N1CCOCC1 |r| Show InChI InChI=1S/C21H24N4O2/c1-15-12-18(16(2)22-17-6-4-3-5-7-17)21-23-19(13-20(26)25(21)14-15)24-8-10-27-11-9-24/h3-7,12-14,16,22H,8-11H2,1-2H3/t16-/m1/s1 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 30 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389046
(CHEMBL2064327)Show InChI InChI=1S/C20H19FN2O3/c1-13-11-14(21)5-6-17(13)26-18-4-2-3-15-16(24)12-19(22-20(15)18)23-7-9-25-10-8-23/h2-6,11-12H,7-10H2,1H3,(H,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 32 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50389069
(CHEMBL2064344)Show SMILES O=c1cc(nc(Cc2nc3ccccc3n2-c2ccccc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C22H21N5O2/c28-22-15-20(26-10-12-29-13-11-26)24-19(25-22)14-21-23-17-8-4-5-9-18(17)27(21)16-6-2-1-3-7-16/h1-9,15H,10-14H2,(H,24,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50389072
(CHEMBL2064341)Show SMILES Fc1ccc2n(C3CC3)c(Cc3nc(cc(=O)[nH]3)N3CCOCC3)nc2c1 Show InChI InChI=1S/C19H20FN5O2/c20-12-1-4-15-14(9-12)21-18(25(15)13-2-3-13)10-16-22-17(11-19(26)23-16)24-5-7-27-8-6-24/h1,4,9,11,13H,2-3,5-8,10H2,(H,22,23,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of poly-His tagged human PI3Kdelta expressed in baculovirus infected insect sf9 cells coexpressing p85alpha using PI(4,5)P2 as substrate p... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449298
(CHEMBL3125388)Show SMILES NC(=O)c1sc(nc1CC(=O)N1CCc2c1cccc2F)N1CCOCC1 Show InChI InChI=1S/C18H19FN4O3S/c19-12-2-1-3-14-11(12)4-5-23(14)15(24)10-13-16(17(20)25)27-18(21-13)22-6-8-26-9-7-22/h1-3H,4-10H2,(H2,20,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 38 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449299
(CHEMBL3125386)Show SMILES CC1Cc2ccccc2N1C(=O)Cc1nc(sc1C(N)=O)N1CCOCC1 Show InChI InChI=1S/C19H22N4O3S/c1-12-10-13-4-2-3-5-15(13)23(12)16(24)11-14-17(18(20)25)27-19(21-14)22-6-8-26-9-7-22/h2-5,12H,6-11H2,1H3,(H2,20,25) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of PI3Kbeta in human PTEN-deficient PC3 cells assessed as Akt phosphorylation at S473 |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389042
(CHEMBL2064331)Show SMILES Fc1ccc2nc(Cc3nc(cc(=O)[nH]3)N3CCOCC3)[nH]c2c1 Show InChI InChI=1S/C16H16FN5O2/c17-10-1-2-11-12(7-10)19-13(18-11)8-14-20-15(9-16(23)21-14)22-3-5-24-6-4-22/h1-2,7,9H,3-6,8H2,(H,18,19)(H,20,21,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389035
(CHEMBL2064419)Show InChI InChI=1S/C16H18N4O3/c21-15(17-12-4-2-1-3-5-12)10-13-18-14(11-16(22)19-13)20-6-8-23-9-7-20/h1-5,11H,6-10H2,(H,17,21)(H,18,19,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL MMDB PC cid PC sid PDB UniChem
Similars
| Article PubMed
| n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389050
(CHEMBL2064415)Show SMILES O=c1cc(nc(Cc2nc3c(cccc3o2)-c2cccnc2)[nH]1)N1CCOCC1 Show InChI InChI=1S/C21H19N5O3/c27-19-12-18(26-7-9-28-10-8-26)23-17(24-19)11-20-25-21-15(4-1-5-16(21)29-20)14-3-2-6-22-13-14/h1-6,12-13H,7-11H2,(H,23,24,27) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 44 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta-mediated Akt phosphorylation at Ser473 residue expressed in PTEN-deficient human PC3 cells by chemiluminescence assay |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50449309
(CHEMBL3125541)Show SMILES NC(=O)c1sc(nc1CC(=O)Nc1ccc(F)c(Cl)c1)N1CCOCC1 Show InChI InChI=1S/C16H16ClFN4O3S/c17-10-7-9(1-2-11(10)18)20-13(23)8-12-14(15(19)24)26-16(21-12)22-3-5-25-6-4-22/h1-2,7H,3-6,8H2,(H2,19,24)(H,20,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta after 15 mins |
Bioorg Med Chem Lett 24: 1506-10 (2014)
Article DOI: 10.1016/j.bmcl.2014.02.004 BindingDB Entry DOI: 10.7270/Q25H7HR2 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50389062
(CHEMBL2064352)Show InChI InChI=1S/C16H15FN4O3/c17-10-1-2-12-11(7-10)18-16(24-12)8-13-19-14(9-15(22)20-13)21-3-5-23-6-4-21/h1-2,7,9H,3-6,8H2,(H,19,20,22) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 46 | n/a | n/a | n/a | n/a | n/a | n/a |
Sanofi Research& Development
Curated by ChEMBL
| Assay Description Inhibition of N-terminus poly-His tagged human PI3Kbeta expressed in baculovirus infected insect S21 cells coexpressing p85alpha using PI(4,5)P2 as s... |
J Med Chem 55: 4788-805 (2012)
Article DOI: 10.1021/jm300241b BindingDB Entry DOI: 10.7270/Q2R78G88 |
More data for this Ligand-Target Pair | |