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Compile Data Set for Download or QSAR

Found 283 hits with Last Name = 'martin' and Initial = 'jg'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50369261
PNG
(CHEMBL1907812)
Show SMILES C[C@H](CN(O)C(N)=O)C#Cc1ccc(Oc2ccc(F)cc2)o1 |r|
Show InChI InChI=1S/C16H15FN2O4/c1-11(10-19(21)16(18)20)2-5-13-8-9-15(22-13)23-14-6-3-12(17)4-7-14/h3-4,6-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m0/s1
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n/an/a 50n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50369069
PNG
(CHEMBL1907933)
Show SMILES C[C@@H](C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O |r|
Show InChI InChI=1S/C15H13FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h3-4,6-10,20H,1H3,(H2,17,19)/t10-/m0/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058635
PNG
(CHEMBL60523 | N-{2-[({(1E)-[5-(4-fluorophenoxy)-2-...)
Show SMILES NC(=O)N(O)CCO\N=C\c1ccc(Oc2ccc(F)cc2)o1
Show InChI InChI=1S/C14H14FN3O5/c15-10-1-3-11(4-2-10)22-13-6-5-12(23-13)9-17-21-8-7-18(20)14(16)19/h1-6,9,20H,7-8H2,(H2,16,19)/b17-9+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029778
PNG
(CHEMBL264717 | N-{3-[5-(4-fluorophenoxy)-2-furyl]p...)
Show SMILES NC(=O)N(O)CC#Cc1ccc(Oc2ccc(F)cc2)o1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-5-12(6-4-10)21-13-8-7-11(20-13)2-1-9-17(19)14(16)18/h3-8,19H,9H2,(H2,16,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058592
PNG
(CHEMBL291993 | N-hydroxy-N-[3-(3-phenoxyphenyl)pro...)
Show SMILES NC(=O)N(O)CC#Cc1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C16H14N2O3/c17-16(19)18(20)11-5-7-13-6-4-10-15(12-13)21-14-8-2-1-3-9-14/h1-4,6,8-10,12,20H,11H2,(H2,17,19)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029778
PNG
(CHEMBL264717 | N-{3-[5-(4-fluorophenoxy)-2-furyl]p...)
Show SMILES NC(=O)N(O)CC#Cc1ccc(Oc2ccc(F)cc2)o1
Show InChI InChI=1S/C14H11FN2O4/c15-10-3-5-12(6-4-10)21-13-8-7-11(20-13)2-1-9-17(19)14(16)18/h3-8,19H,9H2,(H2,16,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029775
PNG
((R)-(+)-N-{3-[5-(4-fluorophenoxy)furan-2-yl]-1-met...)
Show SMILES CC(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H13FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h3-4,6-10,20H,1H3,(H2,17,19)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029776
PNG
(CHEMBL359455 | N-{3-[5-(4-fluorobenzyl)thien-2-yl]...)
Show SMILES NC(=O)N(O)CC#Cc1ccc(Cc2ccc(F)cc2)s1
Show InChI InChI=1S/C15H13FN2O2S/c16-12-5-3-11(4-6-12)10-14-8-7-13(21-14)2-1-9-18(20)15(17)19/h3-8,20H,9-10H2,(H2,17,19)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (l...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50369260
PNG
(CHEMBL1907824)
Show SMILES C[C@@H](CN(O)C(N)=O)C#Cc1ccc(Oc2ccc(F)cc2)o1 |r|
Show InChI InChI=1S/C16H15FN2O4/c1-11(10-19(21)16(18)20)2-5-13-8-9-15(22-13)23-14-6-3-12(17)4-7-14/h3-4,6-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m1/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029775
PNG
((R)-(+)-N-{3-[5-(4-fluorophenoxy)furan-2-yl]-1-met...)
Show SMILES CC(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H13FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h3-4,6-10,20H,1H3,(H2,17,19)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50369068
PNG
(A-79175 | CHEMBL90552)
Show SMILES C[C@H](C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H13FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h3-4,6-10,20H,1H3,(H2,17,19)/t10-/m1/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058554
PNG
(CHEMBL294028 | N-{(2Z)-2-fluoro-3-[5-(4-fluorophen...)
Show SMILES CC(N(O)C(N)=O)C(\F)=C\c1ccc(Oc2ccc(F)cc2)o1
Show InChI InChI=1S/C15H14F2N2O4/c1-9(19(21)15(18)20)13(17)8-12-6-7-14(23-12)22-11-4-2-10(16)3-5-11/h2-9,21H,1H3,(H2,18,20)/b13-8-
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058580
PNG
(CHEMBL300985 | N-hydroxy-N-{[2-(3-phenoxyphenyl)cy...)
Show SMILES NC(=O)N(O)CC1CC1c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C17H18N2O3/c18-17(20)19(21)11-13-10-16(13)12-5-4-8-15(9-12)22-14-6-2-1-3-7-14/h1-9,13,16,21H,10-11H2,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058590
PNG
(CHEMBL293743 | Fenleuton | N-{3-[3-(4-fluorophenox...)
Show SMILES CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058627
PNG
(CHEMBL60174 | N-[3-(1-benzothien-2-yl)-1-methylpro...)
Show SMILES CC(C#Cc1cc2ccccc2s1)N(O)C(N)=O
Show InChI InChI=1S/C13H12N2O2S/c1-9(15(17)13(14)16)6-7-11-8-10-4-2-3-5-12(10)18-11/h2-5,8-9,17H,1H3,(H2,14,16)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058533
PNG
(CHEMBL61888 | N-(1-{5-[(benzyloxy)methyl]-2-furyl}...)
Show SMILES CC(N(O)C(N)=O)c1ccc(COCc2ccccc2)o1
Show InChI InChI=1S/C15H18N2O4/c1-11(17(19)15(16)18)14-8-7-13(21-14)10-20-9-12-5-3-2-4-6-12/h2-8,11,19H,9-10H2,1H3,(H2,16,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058615
PNG
(CHEMBL58335 | N-[1-(1-benzothien-2-yl)ethyl]-N-hyd...)
Show SMILES CCCCCNC(=O)N(O)C(C)c1cc2ccccc2s1
Show InChI InChI=1S/C16H22N2O2S/c1-3-4-7-10-17-16(19)18(20)12(2)15-11-13-8-5-6-9-14(13)21-15/h5-6,8-9,11-12,20H,3-4,7,10H2,1-2H3,(H,17,19)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058585
PNG
(CHEMBL61583 | N-{2-[({(1E)-[5-(4-fluorophenoxy)-2-...)
Show SMILES CC(CO\N=C\c1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H16FN3O5/c1-10(19(21)15(17)20)9-22-18-8-13-6-7-14(24-13)23-12-4-2-11(16)3-5-12/h2-8,10,21H,9H2,1H3,(H2,17,20)/b18-8+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058650
PNG
(CHEMBL58314 | N-[1-(1-benzothien-2-yl)ethyl]-N'-be...)
Show SMILES CC(N(O)C(=O)NCc1ccccc1)c1cc2ccccc2s1
Show InChI InChI=1S/C18H18N2O2S/c1-13(17-11-15-9-5-6-10-16(15)23-17)20(22)18(21)19-12-14-7-3-2-4-8-14/h2-11,13,22H,12H2,1H3,(H,19,21)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058621
PNG
(CHEMBL59119 | N-hydroxy-N-[(2E)-3-(5-phenyl-2-fury...)
Show SMILES NC(=O)N(O)C\C=C\c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O3/c15-14(17)16(18)10-4-7-12-8-9-13(19-12)11-5-2-1-3-6-11/h1-9,18H,10H2,(H2,15,17)/b7-4+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058631
PNG
(CHEMBL59301 | N-hydroxy-N-[(5-phenoxy-2-furyl)meth...)
Show SMILES NC(=O)N(O)Cc1ccc(Oc2ccccc2)o1
Show InChI InChI=1S/C12H12N2O4/c13-12(15)14(16)8-10-6-7-11(18-10)17-9-4-2-1-3-5-9/h1-7,16H,8H2,(H2,13,15)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058628
PNG
(CHEMBL61974 | N-hydroxy-N-[1-(3-phenoxyphenyl)ethy...)
Show SMILES CC(N(O)C(N)=O)c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C15H16N2O3/c1-11(17(19)15(16)18)12-6-5-9-14(10-12)20-13-7-3-2-4-8-13/h2-11,19H,1H3,(H2,16,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058623
PNG
(CHEMBL58425 | N-hydroxy-N-[1-methyl-3-(3-phenoxyph...)
Show SMILES CC(C#Cc1cccc(Oc2ccccc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H16N2O3/c1-13(19(21)17(18)20)10-11-14-6-5-9-16(12-14)22-15-7-3-2-4-8-15/h2-9,12-13,21H,1H3,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058560
PNG
(CHEMBL413102 | N-hydroxy-N-(1-{5-[(E)-2-phenylviny...)
Show SMILES CC(N(O)C(N)=O)c1ccc(\C=C\c2ccccc2)s1
Show InChI InChI=1S/C15H16N2O2S/c1-11(17(19)15(16)18)14-10-9-13(20-14)8-7-12-5-3-2-4-6-12/h2-11,19H,1H3,(H2,16,18)/b8-7+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058614
PNG
(CHEMBL62146 | N-{3-[5-(4-fluorophenoxy)-2-furyl]-1...)
Show SMILES CC(C)(C#Cc1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C16H15FN2O4/c1-16(2,19(21)15(18)20)10-9-13-7-8-14(23-13)22-12-5-3-11(17)4-6-12/h3-8,21H,1-2H3,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058580
PNG
(CHEMBL300985 | N-hydroxy-N-{[2-(3-phenoxyphenyl)cy...)
Show SMILES NC(=O)N(O)CC1CC1c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C17H18N2O3/c18-17(20)19(21)11-13-10-16(13)12-5-4-8-15(9-12)22-14-6-2-1-3-7-14/h1-9,13,16,21H,10-11H2,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058612
PNG
(CHEMBL58336 | N-[1-(1-benzothien-2-yl)ethyl]-N'-bu...)
Show SMILES CCCCNC(=O)N(O)C(C)c1cc2ccccc2s1
Show InChI InChI=1S/C15H20N2O2S/c1-3-4-9-16-15(18)17(19)11(2)14-10-12-7-5-6-8-13(12)20-14/h5-8,10-11,19H,3-4,9H2,1-2H3,(H,16,18)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058643
PNG
(CHEMBL58664 | N-{(2E)-3-[5-(4-fluorophenoxy)-2-fur...)
Show SMILES CC(\C=C\c1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H15FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h2-10,20H,1H3,(H2,17,19)/b5-2+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029781
PNG
((R)-(+)-N-{3-[5-(4-fluorobenzyl)thien-2-yl]-1-meth...)
Show SMILES C[C@H](C#Cc1ccc(Cc2ccc(F)cc2)s1)N(O)C(N)=O
Show InChI InChI=1S/C16H15FN2O2S/c1-11(19(21)16(18)20)2-7-14-8-9-15(22-14)10-12-3-5-13(17)6-4-12/h3-6,8-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m1/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029781
PNG
((R)-(+)-N-{3-[5-(4-fluorobenzyl)thien-2-yl]-1-meth...)
Show SMILES C[C@H](C#Cc1ccc(Cc2ccc(F)cc2)s1)N(O)C(N)=O
Show InChI InChI=1S/C16H15FN2O2S/c1-11(19(21)16(18)20)2-7-14-8-9-15(22-14)10-12-3-5-13(17)6-4-12/h3-6,8-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m1/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058623
PNG
(CHEMBL58425 | N-hydroxy-N-[1-methyl-3-(3-phenoxyph...)
Show SMILES CC(C#Cc1cccc(Oc2ccccc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H16N2O3/c1-13(19(21)17(18)20)10-11-14-6-5-9-16(12-14)22-15-7-3-2-4-8-15/h2-9,12-13,21H,1H3,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058640
PNG
(CHEMBL61752 | N-hydroxy-N-[(2E)-3-(5-methyl-2-fury...)
Show SMILES Cc1ccc(\C=C\CN(O)C(N)=O)o1
Show InChI InChI=1S/C9H12N2O3/c1-7-4-5-8(14-7)3-2-6-11(13)9(10)12/h2-5,13H,6H2,1H3,(H2,10,12)/b3-2+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029780
PNG
(CHEMBL145318 | N-{(2Z)-3-[5-(4-fluorophenoxy)furan...)
Show SMILES CC(\C=C/c1ccc(Oc2ccc(F)cc2)o1)N(O)C(N)=O
Show InChI InChI=1S/C15H15FN2O4/c1-10(18(20)15(17)19)2-5-12-8-9-14(21-12)22-13-6-3-11(16)4-7-13/h2-10,20H,1H3,(H2,17,19)/b5-2-
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058621
PNG
(CHEMBL59119 | N-hydroxy-N-[(2E)-3-(5-phenyl-2-fury...)
Show SMILES NC(=O)N(O)C\C=C\c1ccc(o1)-c1ccccc1
Show InChI InChI=1S/C14H14N2O3/c15-14(17)16(18)10-4-7-12-8-9-13(19-12)11-5-2-1-3-6-11/h1-9,18H,10H2,(H2,15,17)/b7-4+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50022701
PNG
(CHEMBL58810 | N-[1-(4-Benzylsulfanyl-phenyl)-ethyl...)
Show SMILES CC(N(O)C(C)=O)c1ccc(SCc2ccccc2)cc1
Show InChI InChI=1S/C17H19NO2S/c1-13(18(20)14(2)19)16-8-10-17(11-9-16)21-12-15-6-4-3-5-7-15/h3-11,13,20H,12H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase from RBL-1 cells

J Med Chem 31: 1960-4 (1988)


BindingDB Entry DOI: 10.7270/Q2JS9PF1
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058573
PNG
(CHEMBL58779 | N-[1-(1-benzothien-2-yl)ethyl]-N-hyd...)
Show SMILES CC(N(O)C(N)=S)c1cc2ccccc2s1
Show InChI InChI=1S/C11H12N2OS2/c1-7(13(14)11(12)15)10-6-8-4-2-3-5-9(8)16-10/h2-7,14H,1H3,(H2,12,15)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058581
PNG
(CHEMBL59838 | N-hydroxy-N-{1-[4-(1-phenylethoxy)ph...)
Show SMILES CC(Oc1ccc(cc1)C(C)N(O)C(N)=O)c1ccccc1
Show InChI InChI=1S/C17H20N2O3/c1-12(19(21)17(18)20)14-8-10-16(11-9-14)22-13(2)15-6-4-3-5-7-15/h3-13,21H,1-2H3,(H2,18,20)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058555
PNG
(CHEMBL58463 | N-[1-(4-chloro-1-benzothien-2-yl)eth...)
Show SMILES CC(N(O)C(N)=O)c1cc2c(Cl)cccc2s1
Show InChI InChI=1S/C11H11ClN2O2S/c1-6(14(16)11(13)15)10-5-7-8(12)3-2-4-9(7)17-10/h2-6,16H,1H3,(H2,13,15)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029777
PNG
((S)-(-)-N-{3-[5-(4-fluorobenzyl)thien-2-yl]-1-meth...)
Show SMILES C[C@@H](C#Cc1ccc(Cc2ccc(F)cc2)s1)N(O)C(N)=O
Show InChI InChI=1S/C16H15FN2O2S/c1-11(19(21)16(18)20)2-7-14-8-9-15(22-14)10-12-3-5-13(17)6-4-12/h3-6,8-9,11,21H,10H2,1H3,(H2,18,20)/t11-/m0/s1
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Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058625
PNG
(CHEMBL418475 | N-hydroxy-N-({5-[(E)-2-thien-2-ylvi...)
Show SMILES NC(=O)N(O)Cc1ccc(\C=C\c2cccs2)s1
Show InChI InChI=1S/C12H12N2O2S2/c13-12(15)14(16)8-11-6-5-10(18-11)4-3-9-2-1-7-17-9/h1-7,16H,8H2,(H2,13,15)/b4-3+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058632
PNG
(CHEMBL293141 | N-[1-(2,2'-bithien-5-yl)ethyl]-N-hy...)
Show SMILES CC(N(O)C(N)=O)c1ccc(s1)-c1cccs1
Show InChI InChI=1S/C11H12N2O2S2/c1-7(13(15)11(12)14)8-4-5-10(17-8)9-3-2-6-16-9/h2-7,15H,1H3,(H2,12,14)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058556
PNG
(CHEMBL58078 | N-[1-(5-butyl-2-furyl)ethyl]-N-hydro...)
Show SMILES CCCCc1ccc(o1)C(C)N(O)C(N)=O
Show InChI InChI=1S/C11H18N2O3/c1-3-4-5-9-6-7-10(16-9)8(2)13(15)11(12)14/h6-8,15H,3-5H2,1-2H3,(H2,12,14)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50029779
PNG
(CHEMBL144028 | N-{3-[5-(4-fluorobenzyl)thien-2-yl]...)
Show SMILES CC(C#Cc1ccc(Cc2ccc(F)cc2)s1)N(O)C(N)=O
Show InChI InChI=1S/C16H15FN2O2S/c1-11(19(21)16(18)20)2-7-14-8-9-15(22-14)10-12-3-5-13(17)6-4-12/h3-6,8-9,11,21H,10H2,1H3,(H2,18,20)
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n/an/a 200n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
5-lipoxygenase Inhibitory activity was measured by enzyme immunoassay using human whole blood stimulated with calcium ionophore (A23187) and LTB4 (le...

J Med Chem 38: 4768-75 (1996)


BindingDB Entry DOI: 10.7270/Q2V40VV9
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058539
PNG
(CHEMBL302169 | N-hydroxy-N-{[5-(phenylthio)-2-fury...)
Show SMILES NC(=O)N(O)Cc1ccc(Sc2ccccc2)o1
Show InChI InChI=1S/C12H12N2O3S/c13-12(15)14(16)8-9-6-7-11(17-9)18-10-4-2-1-3-5-10/h1-7,16H,8H2,(H2,13,15)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Homo sapiens (Human))		BDBM50058579
PNG
(CHEMBL294092 | N-{[2-(3-furyl)cyclopropyl]methyl}-...)
Show SMILES NC(=O)N(O)CC1CC1c1ccoc1
Show InChI InChI=1S/C9H12N2O3/c10-9(12)11(13)4-7-3-8(7)6-1-2-14-5-6/h1-2,5,7-8,13H,3-4H2,(H2,10,12)
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n/an/a 230n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase (5-LO) measured as LTB4 production in human whole blood stimulated with calcium ionophore (A23187).

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058544
PNG
(CHEMBL58021 | N-({5-[(4-chlorophenyl)thio]thien-2-...)
Show SMILES NC(=O)N(O)Cc1ccc(Sc2ccc(Cl)cc2)s1
Show InChI InChI=1S/C12H11ClN2O2S2/c13-8-1-3-9(4-2-8)18-11-6-5-10(19-11)7-15(17)12(14)16/h1-6,17H,7H2,(H2,14,16)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50015159
PNG
(2-(4-Benzyloxy-phenyl)-N-hydroxy-N-methyl-propiona...)
Show SMILES CC(C(=O)N(C)O)c1ccc(OCc2ccccc2)cc1
Show InChI InChI=1S/C17H19NO3/c1-13(17(19)18(2)20)15-8-10-16(11-9-15)21-12-14-6-4-3-5-7-14/h3-11,13,20H,12H2,1-2H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase in RBL-1 cells

J Med Chem 31: 3-5 (1988)


BindingDB Entry DOI: 10.7270/Q2V40T6C
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50012887
PNG
(CHEMBL65430 | N-Hydroxy-2-(4-isobutyl-phenyl)-N-me...)
Show SMILES CC(C)Cc1ccc(cc1)C(C)C(=O)N(C)O
Show InChI InChI=1S/C14H21NO2/c1-10(2)9-12-5-7-13(8-6-12)11(3)14(16)15(4)17/h5-8,10-11,17H,9H2,1-4H3
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Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase in RBL-1 cells

J Med Chem 31: 3-5 (1988)


BindingDB Entry DOI: 10.7270/Q2V40T6C
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50022687
PNG
(CHEMBL61360 | N-Hydroxy-N-[1-(4-styryl-phenyl)-eth...)
Show SMILES CC(N(O)C(C)=O)c1ccc(\C=C\c2ccccc2)cc1
Show InChI InChI=1S/C18H19NO2/c1-14(19(21)15(2)20)18-12-10-17(11-13-18)9-8-16-6-4-3-5-7-16/h3-14,21H,1-2H3/b9-8+
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Abbott Laboratories

Curated by ChEMBL


Assay Description
In vitro inhibition of 5-lipoxygenase from RBL-1 cells

J Med Chem 31: 1960-4 (1988)


BindingDB Entry DOI: 10.7270/Q2JS9PF1
More data for this
Ligand-Target Pair
Polyunsaturated fatty acid 5-lipoxygenase


(Rattus norvegicus)		BDBM50058590
PNG
(CHEMBL293743 | Fenleuton | N-{3-[3-(4-fluorophenox...)
Show SMILES CC(C#Cc1cccc(Oc2ccc(F)cc2)c1)N(O)C(N)=O
Show InChI InChI=1S/C17H15FN2O3/c1-12(20(22)17(19)21)5-6-13-3-2-4-16(11-13)23-15-9-7-14(18)8-10-15/h2-4,7-12,22H,1H3,(H2,19,21)
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Abbott Laboratories

Curated by ChEMBL


Assay Description
Inhibition of 5-lipoxygenase on rat basophil leukemia cell line lysate (RBL-1 2H3 subline) by measuring 5-HETE production

J Med Chem 40: 1955-68 (1997)


Article DOI: 10.1021/jm9700474
BindingDB Entry DOI: 10.7270/Q2NV9JWT
More data for this
Ligand-Target Pair
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