Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Smoothened homolog (Homo sapiens (Human)) | BDBM50293788 (CHEMBL538867 | N-((2S,3R,3aS,3'R,4a'R,6S,6a'R,6b'S...) | PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | Article PubMed | n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Infinity Pharmaceuticals, Inc Curated by ChEMBL | Assay Description Inhibition of human recombinant SMO expressed in mouse C3H10T1/2 cells assessed as inhibition of association of BODIPY-cyclopamine | J Med Chem 52: 4400-18 (2009) Article DOI: 10.1021/jm900305z BindingDB Entry DOI: 10.7270/Q2CC10QM | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM50366992 (CHEMBL4168754) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 22 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate measured after 2... | ACS Med Chem Lett 9: 612-617 (2018) Article DOI: 10.1021/acsmedchemlett.8b00014 BindingDB Entry DOI: 10.7270/Q2TF00XN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM50366992 (CHEMBL4168754) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 25 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PRMT5 in human MCF7 cells assessed as reduction in SmBB'-Rme2s levels after 48 hrs by Western blot analysis | ACS Med Chem Lett 9: 612-617 (2018) Article DOI: 10.1021/acsmedchemlett.8b00014 BindingDB Entry DOI: 10.7270/Q2TF00XN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM50367026 (CHEMBL4164229) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate measured after 2... | ACS Med Chem Lett 9: 612-617 (2018) Article DOI: 10.1021/acsmedchemlett.8b00014 BindingDB Entry DOI: 10.7270/Q2TF00XN | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396269 (US10314827, Compound 10) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396270 (US10314827, Compound 13) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396271 (US10314827, Compound 20) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396272 (US10314827, Compound 21) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396273 (US10314827, Compound 22) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396274 (US10314827, Compound 23) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396275 (US10314827, Compound 24) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396276 (US10314827, Compound 27 | US10314827, Compound 33) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396277 (US10314827, Compound 29) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396278 (US10314827, Compound 31) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396276 (US10314827, Compound 27 | US10314827, Compound 33) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396280 (US10314827, Compound 35) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396281 (US10314827, Compound 37) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396282 (US10314827, Compound 39) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | 60 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396283 (US10314827, Compound 40) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM50293788 (CHEMBL538867 | N-((2S,3R,3aS,3'R,4a'R,6S,6a'R,6b'S...) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL MCE PC cid PC sid UniChem Patents | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396285 (US10314827, Compound 55) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Methylosome protein 50/Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM50366992 (CHEMBL4168754) | PDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PRMT5/MEP50 complex (unknown origin) expressed in Sf9 insect cells using SGRGKGGKGLGKGGAKRHRKVLRDK-Biotin as substrate by surface plasm... | ACS Med Chem Lett 9: 612-617 (2018) Article DOI: 10.1021/acsmedchemlett.8b00014 BindingDB Entry DOI: 10.7270/Q2TF00XN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396265 (US10314827, Compound 1 | US10314827, Compound 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396266 (US10314827, Compound 7 | US10314827, Compound 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396266 (US10314827, Compound 7 | US10314827, Compound 8) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | >100 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Protein arginine N-methyltransferase 5 (Homo sapiens (Human)) | BDBM50366992 (CHEMBL4168754) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | n/a | 40 | n/a | n/a | n/a | n/a |
Lilly Research Laboratories Curated by ChEMBL | Assay Description Inhibition of PRMT5 in human MCF7 cells assessed as skipping of Mdm4 exon 6 mRNA splicing after 72 hrs by qRT-PCR method | ACS Med Chem Lett 9: 612-617 (2018) Article DOI: 10.1021/acsmedchemlett.8b00014 BindingDB Entry DOI: 10.7270/Q2TF00XN | |||||||||||
More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
Alkaline phosphatase, germ cell type (Homo sapiens (Human)) | BDBM396265 (US10314827, Compound 1 | US10314827, Compound 9) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | n/a | n/a | n/a | n/a | <20 | n/a | n/a | n/a | n/a |
Boehringer Ingelheim Pharmaceuticals Inc. | Assay Description C3H10T1/2 cells were plated in 96 wells with a density of 8×103 cells/well. Cells were grown to confluence (72 hrs). After sonic Hedgehog (250 ng/ml)... | Bioorg Med Chem Lett 18: 1994-9 (2008) BindingDB Entry DOI: 10.7270/Q2QR50GW | |||||||||||
More data for this Ligand-Target Pair |