Found 347 hits with Last Name = 'karbarz' and Initial = 'mj' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM23120
(7-phenyl-1-[5-(pyridin-2-yl)-1,3-oxazol-2-yl]hepta...)Show InChI InChI=1S/C21H22N2O2/c24-19(14-7-2-1-4-10-17-11-5-3-6-12-17)21-23-16-20(25-21)18-13-8-9-15-22-18/h3,5-6,8-9,11-13,15-16H,1-2,4,7,10,14H2 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 20 mins |
Bioorg Med Chem Lett 18: 4838-43 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.081
BindingDB Entry DOI: 10.7270/Q23T9H2B |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402675
(CHEMBL2207348)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4cnccc34)c2)cc1 Show InChI InChI=1S/C24H22ClN5O3/c25-18-4-6-19(7-5-18)32-20-3-1-2-17(14-20)16-29-10-12-30(13-11-29)24(31)27-23-21-8-9-26-15-22(21)33-28-23/h1-9,14-15H,10-13,16H2,(H,27,28,31) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50402675
(CHEMBL2207348)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4cnccc34)c2)cc1 Show InChI InChI=1S/C24H22ClN5O3/c25-18-4-6-19(7-5-18)32-20-3-1-2-17(14-20)16-29-10-12-30(13-11-29)24(31)27-23-21-8-9-26-15-22(21)33-28-23/h1-9,14-15H,10-13,16H2,(H,27,28,31) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 0.700 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174997
(CHEMBL3809683)Show SMILES Clc1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc3cccnc3)c2)nc1 Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-7-22(26-15-19)30-21-5-1-3-18(14-21)13-17-8-11-28(12-9-17)23(29)27-20-4-2-10-25-16-20/h1-7,10,14-17H,8-9,11-13H2,(H,27,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174990
(CHEMBL3809293)Show SMILES FC(F)(F)c1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C24H23F3N4O2/c25-24(26,27)19-6-8-21(9-7-19)33-22-5-1-3-18(15-22)17-30-11-13-31(14-12-30)23(32)29-20-4-2-10-28-16-20/h1-10,15-16H,11-14,17H2,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174984
(CHEMBL3809841)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)c2)cc1 Show InChI InChI=1S/C23H22Cl2N4O2/c24-18-4-6-19(7-5-18)31-20-3-1-2-17(14-20)16-28-10-12-29(13-11-28)23(30)27-22-15-26-9-8-21(22)25/h1-9,14-15H,10-13,16H2,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448310
(CHEMBL3121143)Show SMILES CCSc1ccc(cc1)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H21N3OS/c1-2-25-17-10-8-15(9-11-17)18-12-20(23-14-22-18)21-13-19(24)16-6-4-3-5-7-16/h3-12,14,19,24H,2,13H2,1H3,(H,21,22,23)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50245066
(CHEMBL527204 | N-(benzo[c][1,2,5]thiadiazol-4-yl)-...)Show SMILES O=C(Nc1cccc2nsnc12)N1CCN(CC1)c1nc(ns1)-c1ccccc1 Show InChI InChI=1S/C19H17N7OS2/c27-18(20-14-7-4-8-15-16(14)23-29-22-15)25-9-11-26(12-10-25)19-21-17(24-28-19)13-5-2-1-3-6-13/h1-8H,9-12H2,(H,20,27) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 1.35 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 10 mins |
Bioorg Med Chem Lett 18: 4838-43 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.081
BindingDB Entry DOI: 10.7270/Q23T9H2B |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50394620
(CHEMBL2164602)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50394620
(CHEMBL2164602)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
MCE
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 1.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50350557
(CHEMBL1812715)Show SMILES CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H20ClN3O2/c1-2-26-19-9-8-15(10-16(19)21)17-11-20(24-13-23-17)22-12-18(25)14-6-4-3-5-7-14/h3-11,13,18,25H,2,12H2,1H3,(H,22,23,24)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 1.5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50245066
(CHEMBL527204 | N-(benzo[c][1,2,5]thiadiazol-4-yl)-...)Show SMILES O=C(Nc1cccc2nsnc12)N1CCN(CC1)c1nc(ns1)-c1ccccc1 Show InChI InChI=1S/C19H17N7OS2/c27-18(20-14-7-4-8-15-16(14)23-29-22-15)25-9-11-26(12-10-25)19-21-17(24-28-19)13-5-2-1-3-6-13/h1-8H,9-12H2,(H,20,27) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.02 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 10 mins |
Bioorg Med Chem Lett 18: 4838-43 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.081
BindingDB Entry DOI: 10.7270/Q23T9H2B |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174988
(CHEMBL3808688)Show SMILES Brc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C23H23BrN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402695
(CHEMBL2207356)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nccn34)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-7-9-21(10-8-20)33-22-4-1-3-19(17-22)18-29-13-15-30(16-14-29)25(32)28-24-6-2-5-23-27-11-12-31(23)24/h1-12,17H,13-16,18H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402695
(CHEMBL2207356)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nccn34)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-7-9-21(10-8-20)33-22-4-1-3-19(17-22)18-29-13-15-30(16-14-29)25(32)28-24-6-2-5-23-27-11-12-31(23)24/h1-12,17H,13-16,18H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 2.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50350557
(CHEMBL1812715)Show SMILES CCOc1ccc(cc1Cl)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H20ClN3O2/c1-2-26-19-9-8-15(10-16(19)21)17-11-20(24-13-23-17)22-12-18(25)14-6-4-3-5-7-14/h3-11,13,18,25H,2,12H2,1H3,(H,22,23,24)/t18-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448297
(CHEMBL3121113)Show SMILES CCOc1ccc(cc1C(F)(F)F)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C21H20F3N3O2/c1-2-29-19-9-8-15(10-16(19)21(22,23)24)17-11-20(27-13-26-17)25-12-18(28)14-6-4-3-5-7-14/h3-11,13,18,28H,2,12H2,1H3,(H,25,26,27)/t18-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402692
(CHEMBL2207358)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccnc4nccn34)c2)cc1 Show InChI InChI=1S/C24H23ClN6O2/c25-19-4-6-20(7-5-19)33-21-3-1-2-18(16-21)17-29-12-14-30(15-13-29)24(32)28-22-8-9-26-23-27-10-11-31(22)23/h1-11,16H,12-15,17H2,(H,28,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448337
(CHEMBL3121116)Show SMILES CC(=O)c1ccc(cc1F)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H18FN3O2/c1-13(25)16-8-7-15(9-17(16)21)18-10-20(24-12-23-18)22-11-19(26)14-5-3-2-4-6-14/h2-10,12,19,26H,11H2,1H3,(H,22,23,24)/t19-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 3.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174991
(CHEMBL3809071)Show SMILES Fc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)c2)cc1 Show InChI InChI=1S/C23H22ClFN4O2/c24-21-8-9-26-15-22(21)27-23(30)29-12-10-28(11-13-29)16-17-2-1-3-20(14-17)31-19-6-4-18(25)5-7-19/h1-9,14-15H,10-13,16H2,(H,27,30) | PDB
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| n/a | n/a | 3.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402679
(CHEMBL2207344)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnc4[nH]ccc4c3)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-4-6-22(7-5-20)33-23-3-1-2-18(14-23)17-30-10-12-31(13-11-30)25(32)29-21-15-19-8-9-27-24(19)28-16-21/h1-9,14-16H,10-13,17H2,(H,27,28)(H,29,32) | PDB
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| n/a | n/a | 3.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402694
(CHEMBL2203328)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnc4cccnn34)c2)cc1 Show InChI InChI=1S/C24H23ClN6O2/c25-19-6-8-20(9-7-19)33-21-4-1-3-18(15-21)17-29-11-13-30(14-12-29)24(32)28-23-16-26-22-5-2-10-27-31(22)23/h1-10,15-16H,11-14,17H2,(H,28,32) | PDB
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| n/a | n/a | 3.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174994
(CHEMBL3809332)Show SMILES Clc1ccc(Oc2cccc(CC3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C24H24ClN3O2/c25-20-6-8-22(9-7-20)30-23-5-1-3-19(16-23)15-18-10-13-28(14-11-18)24(29)27-21-4-2-12-26-17-21/h1-9,12,16-18H,10-11,13-15H2,(H,27,29) | PDB
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| n/a | n/a | 4.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448317
(CHEMBL3121136)Show SMILES CC(C)c1ccc(cc1)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C21H23N3O/c1-15(2)16-8-10-17(11-9-16)19-12-21(24-14-23-19)22-13-20(25)18-6-4-3-5-7-18/h3-12,14-15,20,25H,13H2,1-2H3,(H,22,23,24)/t20-/m0/s1 | PDB
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| n/a | n/a | 5 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402685
(CHEMBL2207365)Show SMILES Clc1conc1NC(=O)N1CCN(Cc2cccc(Oc3ccc(Cl)cc3)c2)CC1 Show InChI InChI=1S/C21H20Cl2N4O3/c22-16-4-6-17(7-5-16)30-18-3-1-2-15(12-18)13-26-8-10-27(11-9-26)21(28)24-20-19(23)14-29-25-20/h1-7,12,14H,8-11,13H2,(H,24,25,28) | PDB
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| n/a | n/a | 5.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448334
(CHEMBL3121119)Show SMILES O[C@@H](CNc1cc(ncn1)-c1ccc(c(Cl)c1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C19H15ClF3N3O/c20-15-8-13(6-7-14(15)19(21,22)23)16-9-18(26-11-25-16)24-10-17(27)12-4-2-1-3-5-12/h1-9,11,17,27H,10H2,(H,24,25,26)/t17-/m0/s1 | PDB
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| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50447674
(CHEMBL3112940)Show SMILES Clc1ccc(Oc2cccc(CN3CC4(C3)CCN(CC4)C(=O)Nc3noc4ccccc34)c2)cc1 Show InChI InChI=1S/C28H27ClN4O3/c29-21-8-10-22(11-9-21)35-23-5-3-4-20(16-23)17-32-18-28(19-32)12-14-33(15-13-28)27(34)30-26-24-6-1-2-7-25(24)36-31-26/h1-11,16H,12-15,17-19H2,(H,30,31,34) | PDB
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| n/a | n/a | 5.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, L.L.C.
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH after 60 mins |
Bioorg Med Chem Lett 24: 737-41 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.113
BindingDB Entry DOI: 10.7270/Q2CN75DP |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50448337
(CHEMBL3121116)Show SMILES CC(=O)c1ccc(cc1F)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C20H18FN3O2/c1-13(25)16-8-7-15(9-17(16)21)18-10-20(24-12-23-18)22-11-19(26)14-5-3-2-4-6-14/h2-10,12,19,26H,11H2,1H3,(H,22,23,24)/t19-/m0/s1 | PDB
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| n/a | n/a | 5.40 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50402695
(CHEMBL2207356)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nccn34)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-7-9-21(10-8-20)33-22-4-1-3-19(17-22)18-29-13-15-30(16-14-29)25(32)28-24-6-2-5-23-27-11-12-31(23)24/h1-12,17H,13-16,18H2,(H,28,32) | PDB
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PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant rat FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation anal... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50402695
(CHEMBL2207356)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nccn34)c2)cc1 Show InChI InChI=1S/C25H24ClN5O2/c26-20-7-9-21(10-8-20)33-22-4-1-3-19(17-22)18-29-13-15-30(16-14-29)25(32)28-24-6-2-5-23-27-11-12-31(23)24/h1-12,17H,13-16,18H2,(H,28,32) | PDB
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GoogleScholar
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PubMed
| n/a | n/a | 5.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402683
(CHEMBL2207340)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccc4nsnc34)c2)cc1 Show InChI InChI=1S/C24H22ClN5O2S/c25-18-7-9-19(10-8-18)32-20-4-1-3-17(15-20)16-29-11-13-30(14-12-29)24(31)26-21-5-2-6-22-23(21)28-33-27-22/h1-10,15H,11-14,16H2,(H,26,31) | PDB
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antibodypedia
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| n/a | n/a | 5.80 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50394629
(CHEMBL2164596 | US9169224, 60)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1 Show InChI InChI=1S/C24H24ClN3O2/c25-20-9-11-22(12-10-20)30-23-8-4-5-19(17-23)18-27-13-15-28(16-14-27)24(29)26-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2,(H,26,29) | PDB
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PubMed
| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50394629
(CHEMBL2164596 | US9169224, 60)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1 Show InChI InChI=1S/C24H24ClN3O2/c25-20-9-11-22(12-10-20)30-23-8-4-5-19(17-23)18-27-13-15-28(16-14-27)24(29)26-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2,(H,26,29) | PDB
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| n/a | n/a | 6 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50244890
(CHEMBL472535 | N-(2-fluorophenyl)-4-(3-phenyl-1,2,...)Show SMILES Fc1ccccc1NC(=O)N1CCN(CC1)c1nc(ns1)-c1ccccc1 Show InChI InChI=1S/C19H18FN5OS/c20-15-8-4-5-9-16(15)21-18(26)24-10-12-25(13-11-24)19-22-17(23-27-19)14-6-2-1-3-7-14/h1-9H,10-13H2,(H,21,26) | PDB
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| n/a | n/a | 6.20 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 20 mins |
Bioorg Med Chem Lett 18: 4838-43 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.081
BindingDB Entry DOI: 10.7270/Q23T9H2B |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50245030
(4-(3-phenyl-1,2,4-thiadiazol-5-yl)-N-(pyrimidin-4-...)Show InChI InChI=1S/C17H17N7OS/c25-16(20-14-6-7-18-12-19-14)23-8-10-24(11-9-23)17-21-15(22-26-17)13-4-2-1-3-5-13/h1-7,12H,8-11H2,(H,18,19,20,25) | PDB
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PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Johnson & Johnson Pharmaceutical Research and Development
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 10 mins |
Bioorg Med Chem Lett 18: 4838-43 (2008)
Article DOI: 10.1016/j.bmcl.2008.07.081
BindingDB Entry DOI: 10.7270/Q23T9H2B |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448338
(CHEMBL3121115)Show SMILES O[C@@H](CNc1cc(ncn1)-c1ccc(OCC(F)(F)F)c(F)c1)c1ccccc1 |r| Show InChI InChI=1S/C20H17F4N3O2/c21-15-8-14(6-7-18(15)29-11-20(22,23)24)16-9-19(27-12-26-16)25-10-17(28)13-4-2-1-3-5-13/h1-9,12,17,28H,10-11H2,(H,25,26,27)/t17-/m0/s1 | PDB
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| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50448334
(CHEMBL3121119)Show SMILES O[C@@H](CNc1cc(ncn1)-c1ccc(c(Cl)c1)C(F)(F)F)c1ccccc1 |r| Show InChI InChI=1S/C19H15ClF3N3O/c20-15-8-13(6-7-14(15)19(21,22)23)16-9-18(26-11-25-16)24-10-17(27)12-4-2-1-3-5-12/h1-9,11,17,27H,10H2,(H,24,25,26)/t17-/m0/s1 | PDB
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UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
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UniChem
Similars
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PubMed
| n/a | n/a | 6.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402680
(CHEMBL2207343)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cncc4ccccc34)c2)cc1 Show InChI InChI=1S/C27H25ClN4O2/c28-22-8-10-23(11-9-22)34-24-6-3-4-20(16-24)19-31-12-14-32(15-13-31)27(33)30-26-18-29-17-21-5-1-2-7-25(21)26/h1-11,16-18H,12-15,19H2,(H,30,33) | PDB
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| n/a | n/a | 6.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50448297
(CHEMBL3121113)Show SMILES CCOc1ccc(cc1C(F)(F)F)-c1cc(NC[C@H](O)c2ccccc2)ncn1 |r| Show InChI InChI=1S/C21H20F3N3O2/c1-2-29-19-9-8-15(10-16(19)21(22,23)24)17-11-20(27-13-26-17)25-12-18(28)14-6-4-3-5-7-14/h3-11,13,18,28H,2,12H2,1H3,(H,25,26,27)/t18-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50448326
(CHEMBL3121127)Show SMILES O[C@@H](CNc1cc(ncn1)-c1ccc(c(Cl)c1)C(F)(F)F)c1ccc(F)c(F)c1 |r| Show InChI InChI=1S/C19H13ClF5N3O/c20-13-5-10(1-3-12(13)19(23,24)25)16-7-18(28-9-27-16)26-8-17(29)11-2-4-14(21)15(22)6-11/h1-7,9,17,29H,8H2,(H,26,27,28)/t17-/m0/s1 | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402689
(CHEMBL2207361)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnn3)c2)cc1 Show InChI InChI=1S/C22H22ClN5O2/c23-18-6-8-19(9-7-18)30-20-4-1-3-17(15-20)16-27-11-13-28(14-12-27)22(29)25-21-5-2-10-24-26-21/h1-10,15H,11-14,16H2,(H,25,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402681
(CHEMBL2207342)Show SMILES Cc1nc2cc(NC(=O)N3CCN(Cc4cccc(Oc5ccc(Cl)cc5)c4)CC3)ccc2o1 Show InChI InChI=1S/C26H25ClN4O3/c1-18-28-24-16-21(7-10-25(24)33-18)29-26(32)31-13-11-30(12-14-31)17-19-3-2-4-23(15-19)34-22-8-5-20(27)6-9-22/h2-10,15-16H,11-14,17H2,1H3,(H,29,32) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 7.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50447654
(CHEMBL3112760)Show SMILES Clc1ccc(Oc2cccc(CN3CCC4(CN(C4)C(=O)Nc4cnccc4Cl)CC3)c2)cc1 Show InChI InChI=1S/C26H26Cl2N4O2/c27-20-4-6-21(7-5-20)34-22-3-1-2-19(14-22)16-31-12-9-26(10-13-31)17-32(18-26)25(33)30-24-15-29-11-8-23(24)28/h1-8,11,14-15H,9-10,12-13,16-18H2,(H,30,33) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, L.L.C.
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH after 60 mins |
Bioorg Med Chem Lett 24: 737-41 (2014)
Article DOI: 10.1016/j.bmcl.2013.12.113
BindingDB Entry DOI: 10.7270/Q2CN75DP |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50448309
(CHEMBL3121144)Show SMILES O[C@@H](CNc1cc(ncn1)-c1ccc(SC(F)(F)F)cc1)c1ccccc1 |r| Show InChI InChI=1S/C19H16F3N3OS/c20-19(21,22)27-15-8-6-13(7-9-15)16-10-18(25-12-24-16)23-11-17(26)14-4-2-1-3-5-14/h1-10,12,17,26H,11H2,(H,23,24,25)/t17-/m0/s1 | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of human FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50448324
(CHEMBL3121129)Show SMILES OC(CNc1cc(ncn1)-c1ccc(c(Cl)c1)C(F)(F)F)c1ccc(F)c(Cl)c1 Show InChI InChI=1S/C19H13Cl2F4N3O/c20-13-5-10(1-3-12(13)19(23,24)25)16-7-18(28-9-27-16)26-8-17(29)11-2-4-15(22)14(21)6-11/h1-7,9,17,29H,8H2,(H,26,27,28) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH |
Bioorg Med Chem Lett 24: 1280-4 (2014)
Article DOI: 10.1016/j.bmcl.2014.01.064
BindingDB Entry DOI: 10.7270/Q2TH8P67 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50174992
(CHEMBL3809180)Show SMILES Clc1ccc(Oc2cc(Cl)cc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1 Show InChI InChI=1S/C23H22Cl2N4O2/c24-18-3-5-21(6-4-18)31-22-13-17(12-19(25)14-22)16-28-8-10-29(11-9-28)23(30)27-20-2-1-7-26-15-20/h1-7,12-15H,8-11,16H2,(H,27,30) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50402677
(CHEMBL2207346)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4ccccc34)c2)cc1 Show InChI InChI=1S/C25H23ClN4O3/c26-19-8-10-20(11-9-19)32-21-5-3-4-18(16-21)17-29-12-14-30(15-13-29)25(31)27-24-22-6-1-2-7-23(22)33-28-24/h1-11,16H,12-15,17H2,(H,27,28,31) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant rat FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation anal... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50402677
(CHEMBL2207346)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3noc4ccccc34)c2)cc1 Show InChI InChI=1S/C25H23ClN4O3/c26-19-8-10-20(11-9-19)32-21-5-3-4-18(16-21)17-29-12-14-30(15-13-29)25(31)27-24-22-6-1-2-7-23(22)33-28-24/h1-11,16H,12-15,17H2,(H,27,28,31) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.10 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1 [30-579]
(Rattus norvegicus (rat)) | BDBM50402680
(CHEMBL2207343)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cncc4ccccc34)c2)cc1 Show InChI InChI=1S/C27H25ClN4O2/c28-22-8-10-23(11-9-22)34-24-6-3-4-20(16-24)19-31-12-14-32(15-13-31)27(33)30-26-18-29-17-21-5-1-2-7-25(21)26/h1-11,16-18H,12-15,19H2,(H,30,33) | PDB
MMDB
UniProtKB/SwissProt
B.MOAD
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 8.30 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Research and Development, LLC
Curated by ChEMBL
| Assay Description
Inhibition of rat FAAH preincubated for 60 mins |
Bioorg Med Chem Lett 22: 7357-62 (2012)
Article DOI: 10.1016/j.bmcl.2012.10.076
BindingDB Entry DOI: 10.7270/Q28S4R30 |
More data for this
Ligand-Target Pair | |
Fatty-acid amide hydrolase 1
(Homo sapiens (Human)) | BDBM50402690
(CHEMBL2207360)Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cnccn3)c2)cc1 Show InChI InChI=1S/C22H22ClN5O2/c23-18-4-6-19(7-5-18)30-20-3-1-2-17(14-20)16-27-10-12-28(13-11-27)22(29)26-21-15-24-8-9-25-21/h1-9,14-15H,10-13,16H2,(H,25,26,29) | PDB
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.70 | n/a | n/a | n/a | n/a | n/a | n/a |
Janssen Pharmaceutical Companies of Johnson& Johnson, L.L.C.
Curated by ChEMBL
| Assay Description
Apparent inhibition of recombinant human FAAH expressed in SK-N-MC cells assessed as [3H]-anandamide hydrolysis after 1 hr by liquid scintillation an... |
Bioorg Med Chem Lett 26: 3109-14 (2016)
Article DOI: 10.1016/j.bmcl.2016.05.001
BindingDB Entry DOI: 10.7270/Q25B04F3 |
More data for this
Ligand-Target Pair | |
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