Compile Data Set for Download or QSAR

Found 2305 hits with Last Name = 'campbell' and Initial = 'sf'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226239 (CHEMBL50451) Show SMILES COc1nc(OC)nc(n1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C19H24N8O4/c1-28-13-9-11-12(10-14(13)29-2)21-16(22-15(11)20)26-5-7-27(8-6-26)17-23-18(30-3)25-19(24-17)31-4/h9-10H,5-8H2,1-4H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.0800	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226814 (CHEMBL6424) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCc1ccccc1 Show InChI InChI=1S/C24H29N5O3/c1-31-20-14-18-19(15-21(20)32-2)27-24(28-22(18)25)29-12-9-17(10-13-29)23(30)26-11-8-16-6-4-3-5-7-16/h3-7,14-15,17H,8-13H2,1-2H3,(H,26,30)(H2,25,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227376 (CHEMBL8689) Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C20H22N4O4/c1-26-17-10-13-14(21)11-19(22-15(13)12-18(17)27-2)23-5-7-24(8-6-23)20(25)16-4-3-9-28-16/h3-4,9-12H,5-8H2,1-2H3,(H2,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.140	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227298 (CHEMBL147255) Show SMILES CCOC(C)(COC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1)c1ccccc1 Show InChI InChI=1S/C26H34N4O4/c1-5-34-26(2,18-9-7-6-8-10-18)17-33-19-11-13-30(14-12-19)25-28-21-16-23(32-4)22(31-3)15-20(21)24(27)29-25/h6-10,15-16,19H,5,11-14,17H2,1-4H3,(H2,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227290 (CHEMBL148457) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)OCC(O)c1ccccc1 Show InChI InChI=1S/C23H28N4O4/c1-29-20-12-17-18(13-21(20)30-2)25-23(26-22(17)24)27-10-8-16(9-11-27)31-14-19(28)15-6-4-3-5-7-15/h3-7,12-13,16,19,28H,8-11,14H2,1-2H3,(H2,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.150	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226234 (CHEMBL50979) Show SMILES COc1cc(nc(OC)n1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C20H25N7O4/c1-28-14-9-12-13(10-15(14)29-2)22-19(25-18(12)21)27-7-5-26(6-8-27)16-11-17(30-3)24-20(23-16)31-4/h9-11H,5-8H2,1-4H3,(H2,21,22,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL MMDB PC cid PC sid UniChem Patents Similars	PubMed	0.160	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226235 (CHEMBL54288) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1cc(OC(C)C)ncn1 Show InChI InChI=1S/C21H27N7O3/c1-13(2)31-19-11-18(23-12-24-19)27-5-7-28(8-6-27)21-25-15-10-17(30-4)16(29-3)9-14(15)20(22)26-21/h9-13H,5-8H2,1-4H3,(H2,22,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226227 (CHEMBL52155) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1cnccn1 Show InChI InChI=1S/C18H21N7O2/c1-26-14-9-12-13(10-15(14)27-2)22-18(23-17(12)19)25-7-5-24(6-8-25)16-11-20-3-4-21-16/h3-4,9-11H,5-8H2,1-2H3,(H2,19,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.180	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity to Alpha-1 adrenergic receptor by displacement of [3H]prazosin				J Med Chem 31: 1036-9 (1988) BindingDB Entry DOI: 10.7270/Q2639RZK
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Compound was tested for its binding affinity for alpha-1 adrenergic receptor site by displacement of [3H]clonidine at 10e-6 M concentration				J Med Chem 30: 49-57 (1987) BindingDB Entry DOI: 10.7270/Q24J0HCH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM29568 (CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccco1 Show InChI InChI=1S/C19H21N5O4/c1-26-15-10-12-13(11-16(15)27-2)21-19(22-17(12)20)24-7-5-23(6-8-24)18(25)14-4-3-9-28-14/h3-4,9-11H,5-8H2,1-2H3,(H2,20,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor was determined by displacement of [3H]-prazosin in rat brain homogenates.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226233 (CHEMBL275524) Show SMILES COc1ccnc(n1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C19H23N7O3/c1-27-14-10-12-13(11-15(14)28-2)22-19(24-17(12)20)26-8-6-25(7-9-26)18-21-5-4-16(23-18)29-3/h4-5,10-11H,6-9H2,1-3H3,(H2,20,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.190	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226844 (CHEMBL415288) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)N(C)Cc1ccccc1 Show InChI InChI=1S/C24H29N5O3/c1-28(15-16-7-5-4-6-8-16)23(30)17-9-11-29(12-10-17)24-26-19-14-21(32-3)20(31-2)13-18(19)22(25)27-24/h4-8,13-14,17H,9-12,15H2,1-3H3,(H2,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.200	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226846 (CHEMBL6474) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCc1ccccc1 Show InChI InChI=1S/C23H27N5O3/c1-30-19-12-17-18(13-20(19)31-2)26-23(27-21(17)24)28-10-8-16(9-11-28)22(29)25-14-15-6-4-3-5-7-15/h3-7,12-13,16H,8-11,14H2,1-2H3,(H,25,29)(H2,24,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.220	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226237 (CHEMBL299584) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1ccnc(Oc2ccccc2)n1 Show InChI InChI=1S/C24H25N7O3/c1-32-19-14-17-18(15-20(19)33-2)27-23(29-22(17)25)31-12-10-30(11-13-31)21-8-9-26-24(28-21)34-16-6-4-3-5-7-16/h3-9,14-15H,10-13H2,1-2H3,(H2,25,27,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.240	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226229 (CHEMBL52439) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1ncccn1 Show InChI InChI=1S/C18H21N7O2/c1-26-14-10-12-13(11-15(14)27-2)22-18(23-16(12)19)25-8-6-24(7-9-25)17-20-4-3-5-21-17/h3-5,10-11H,6-9H2,1-2H3,(H2,19,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.260	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226225 (CHEMBL50746) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1nccc(n1)N(C)C Show InChI InChI=1S/C20H26N8O2/c1-26(2)17-5-6-22-19(24-17)27-7-9-28(10-8-27)20-23-14-12-16(30-4)15(29-3)11-13(14)18(21)25-20/h5-6,11-12H,7-10H2,1-4H3,(H2,21,23,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226228 (CHEMBL50137) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1ccncn1 Show InChI InChI=1S/C18H21N7O2/c1-26-14-9-12-13(10-15(14)27-2)22-18(23-17(12)19)25-7-5-24(6-8-25)16-3-4-20-11-21-16/h3-4,9-11H,5-8H2,1-2H3,(H2,19,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.270	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227379 (CHEMBL267428) Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)C(=O)NCC=C Show InChI InChI=1S/C19H25N5O3/c1-4-5-21-19(25)24-8-6-23(7-9-24)18-11-14(20)13-10-16(26-2)17(27-3)12-15(13)22-18/h4,10-12H,1,5-9H2,2-3H3,(H2,20,22)(H,21,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226238 (CHEMBL301614) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1ccc(OC(C)C)nn1 Show InChI InChI=1S/C21H27N7O3/c1-13(2)31-19-6-5-18(25-26-19)27-7-9-28(10-8-27)21-23-15-12-17(30-4)16(29-3)11-14(15)20(22)24-21/h5-6,11-13H,7-10H2,1-4H3,(H2,22,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.290	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226241 (CHEMBL301749) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1ccnc(n1)N1CCOCC1 Show InChI InChI=1S/C22H28N8O3/c1-31-17-13-15-16(14-18(17)32-2)25-22(27-20(15)23)29-7-5-28(6-8-29)19-3-4-24-21(26-19)30-9-11-33-12-10-30/h3-4,13-14H,5-12H2,1-2H3,(H2,23,25,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.310	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226230 (CHEMBL50084) Show SMILES CCCOc1ccnc(n1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C21H27N7O3/c1-4-11-31-18-5-6-23-20(25-18)27-7-9-28(10-8-27)21-24-15-13-17(30-3)16(29-2)12-14(15)19(22)26-21/h5-6,12-13H,4,7-11H2,1-3H3,(H2,22,24,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.320	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227369 (CHEMBL268416) Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C22H25N5O3/c1-29-19-12-16-17(23)13-21(25-18(16)14-20(19)30-2)26-8-10-27(11-9-26)22(28)24-15-6-4-3-5-7-15/h3-7,12-14H,8-11H2,1-2H3,(H2,23,25)(H,24,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.340	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226242 (CHEMBL51056) Show SMILES CCCOc1cc(ncn1)N1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C21H27N7O3/c1-4-9-31-19-12-18(23-13-24-19)27-5-7-28(8-6-27)21-25-15-11-17(30-3)16(29-2)10-14(15)20(22)26-21/h10-13H,4-9H2,1-3H3,(H2,22,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	0.360	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226231 (CHEMBL50473) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1cccnn1 Show InChI InChI=1S/C18H21N7O2/c1-26-14-10-12-13(11-15(14)27-2)21-18(22-17(12)19)25-8-6-24(7-9-25)16-4-3-5-20-23-16/h3-5,10-11H,6-9H2,1-2H3,(H2,19,21,22)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226812 (CHEMBL266317) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCCOc1ccccc1 Show InChI InChI=1S/C24H29N5O4/c1-31-20-14-18-19(15-21(20)32-2)27-24(28-22(18)25)29-11-8-16(9-12-29)23(30)26-10-13-33-17-6-4-3-5-7-17/h3-7,14-16H,8-13H2,1-2H3,(H,26,30)(H2,25,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227368 (CHEMBL8603) Show SMILES CCOc1ccnc(n1)N1CCN(CC1)c1cc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C21H26N6O3/c1-4-30-20-5-6-23-21(25-20)27-9-7-26(8-10-27)19-12-15(22)14-11-17(28-2)18(29-3)13-16(14)24-19/h5-6,11-13H,4,7-10H2,1-3H3,(H2,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.420	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227374 (CHEMBL8369) Show SMILES CCCNC(=O)N1CCN(CC1)c1cc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C19H27N5O3/c1-4-5-21-19(25)24-8-6-23(7-9-24)18-11-14(20)13-10-16(26-2)17(27-3)12-15(13)22-18/h10-12H,4-9H2,1-3H3,(H2,20,22)(H,21,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.440	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227372 (CHEMBL8585) Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)c1nccc(n1)N(C)C Show InChI InChI=1S/C21H27N7O2/c1-26(2)19-5-6-23-21(25-19)28-9-7-27(8-10-28)20-12-15(22)14-11-17(29-3)18(30-4)13-16(14)24-20/h5-6,11-13H,7-10H2,1-4H3,(H2,22,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.460	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226839 (CHEMBL267457) Show SMILES CCCCNC(=O)CCC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C22H33N5O3/c1-4-5-10-24-20(28)7-6-15-8-11-27(12-9-15)22-25-17-14-19(30-3)18(29-2)13-16(17)21(23)26-22/h13-15H,4-12H2,1-3H3,(H,24,28)(H2,23,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226232 (CHEMBL300972) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1nc(N)nc(N)n1 Show InChI InChI=1S/C17H22N10O2/c1-28-11-7-9-10(8-12(11)29-2)21-16(22-13(9)18)26-3-5-27(6-4-26)17-24-14(19)23-15(20)25-17/h7-8H,3-6H2,1-2H3,(H2,18,21,22)(H4,19,20,23,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226847 (CHEMBL6380) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)Nc1ccccc1 Show InChI InChI=1S/C22H25N5O3/c1-29-18-12-16-17(13-19(18)30-2)25-22(26-20(16)23)27-10-8-14(9-11-27)21(28)24-15-6-4-3-5-7-15/h3-7,12-14H,8-11H2,1-2H3,(H,24,28)(H2,23,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.470	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227287 (CHEMBL147393) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)OCCOc1ccccc1 Show InChI InChI=1S/C23H28N4O4/c1-28-20-14-18-19(15-21(20)29-2)25-23(26-22(18)24)27-10-8-17(9-11-27)31-13-12-30-16-6-4-3-5-7-16/h3-7,14-15,17H,8-13H2,1-2H3,(H2,24,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.480	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227373 (CHEMBL266119) Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)C(=O)c1ccccc1 Show InChI InChI=1S/C22H24N4O3/c1-28-19-12-16-17(23)13-21(24-18(16)14-20(19)29-2)25-8-10-26(11-9-25)22(27)15-6-4-3-5-7-15/h3-7,12-14H,8-11H2,1-2H3,(H2,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.490	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227289 (CHEMBL149047) Show SMILES CCOC(COC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1)c1ccccc1 Show InChI InChI=1S/C25H32N4O4/c1-4-32-23(17-8-6-5-7-9-17)16-33-18-10-12-29(13-11-18)25-27-20-15-22(31-3)21(30-2)14-19(20)24(26)28-25/h5-9,14-15,18,23H,4,10-13,16H2,1-3H3,(H2,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.520	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227296 (CHEMBL150112) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)OCC(C)(O)c1ccccc1 Show InChI InChI=1S/C24H30N4O4/c1-24(29,16-7-5-4-6-8-16)15-32-17-9-11-28(12-10-17)23-26-19-14-21(31-3)20(30-2)13-18(19)22(25)27-23/h4-8,13-14,17,29H,9-12,15H2,1-3H3,(H2,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.620	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227381 (CHEMBL267804) Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)c1nccc(C)n1 Show InChI InChI=1S/C20H24N6O2/c1-13-4-5-22-20(23-13)26-8-6-25(7-9-26)19-11-15(21)14-10-17(27-2)18(28-3)12-16(14)24-19/h4-5,10-12H,6-9H2,1-3H3,(H2,21,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226848 (CHEMBL6598) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NC1CCCC1 Show InChI InChI=1S/C21H29N5O3/c1-28-17-11-15-16(12-18(17)29-2)24-21(25-19(15)22)26-9-7-13(8-10-26)20(27)23-14-5-3-4-6-14/h11-14H,3-10H2,1-2H3,(H,23,27)(H2,22,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.630	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226813 (CHEMBL6766) Show SMILES CCCNC(=O)CC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C20H29N5O3/c1-4-7-22-18(26)10-13-5-8-25(9-6-13)20-23-15-12-17(28-3)16(27-2)11-14(15)19(21)24-20/h11-13H,4-10H2,1-3H3,(H,22,26)(H2,21,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.650	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227294 (CHEMBL149262) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)OCCOC(C)C Show InChI InChI=1S/C20H30N4O4/c1-13(2)27-9-10-28-14-5-7-24(8-6-14)20-22-16-12-18(26-4)17(25-3)11-15(16)19(21)23-20/h11-14H,5-10H2,1-4H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	0.670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226853 (CHEMBL6556) Show SMILES CCCCNC(=O)C1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C20H29N5O3/c1-4-5-8-22-19(26)13-6-9-25(10-7-13)20-23-15-12-17(28-3)16(27-2)11-14(15)18(21)24-20/h11-13H,4-10H2,1-3H3,(H,22,26)(H2,21,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.670	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226842 (CHEMBL6481) Show SMILES CCCCNC(=O)COC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C21H31N5O4/c1-4-5-8-23-19(27)13-30-14-6-9-26(10-7-14)21-24-16-12-18(29-3)17(28-2)11-15(16)20(22)25-21/h11-12,14H,4-10,13H2,1-3H3,(H,23,27)(H2,22,24,25)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.790	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227380 (CHEMBL8632) Show SMILES COc1cc2nc(cc(N)c2cc1OC)N1CCN(CC1)C(=O)C1COc2ccccc2O1 Show InChI InChI=1S/C24H26N4O5/c1-30-20-11-15-16(25)12-23(26-17(15)13-21(20)31-2)27-7-9-28(10-8-27)24(29)22-14-32-18-5-3-4-6-19(18)33-22/h3-6,11-13,22H,7-10,14H2,1-2H3,(H2,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.810	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity towards alpha-1 adrenergic receptor from rat brain homogenate preparation by displacement of [3H]prazosin				J Med Chem 31: 1031-5 (1988) BindingDB Entry DOI: 10.7270/Q29W0HPJ
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226236 (CHEMBL300632) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1nc(Oc2ccccc2)nc(Oc2ccccc2)n1 Show InChI InChI=1S/C29H28N8O4/c1-38-23-17-21-22(18-24(23)39-2)31-26(32-25(21)30)36-13-15-37(16-14-36)27-33-28(40-19-9-5-3-6-10-19)35-29(34-27)41-20-11-7-4-8-12-20/h3-12,17-18H,13-16H2,1-2H3,(H2,30,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.870	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226838 (CHEMBL6447) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCC(CC1)C(=O)NCC1CC1 Show InChI InChI=1S/C20H27N5O3/c1-27-16-9-14-15(10-17(16)28-2)23-20(24-18(14)21)25-7-5-13(6-8-25)19(26)22-11-12-3-4-12/h9-10,12-13H,3-8,11H2,1-2H3,(H,22,26)(H2,21,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.900	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity determined for alpha-1 adrenergic receptor by the displacement of [3H]- prazosin.				J Med Chem 30: 999-1003 (1987) BindingDB Entry DOI: 10.7270/Q2PC34MG
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50226240 (CHEMBL298946) Show SMILES COc1cc2nc(nc(N)c2cc1OC)N1CCN(CC1)c1nccc(C)n1 Show InChI InChI=1S/C19H23N7O2/c1-12-4-5-21-18(22-12)25-6-8-26(9-7-25)19-23-14-11-16(28-3)15(27-2)10-13(14)17(20)24-19/h4-5,10-11H,6-9H2,1-3H3,(H2,20,23,24)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.920	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity against alpha-1-adrenoceptor in rat brain homogenates [3H]-prazosin displacement.				J Med Chem 30: 1794-8 (1987) BindingDB Entry DOI: 10.7270/Q2W0985N
					More data for this Ligand-Target Pair
Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor (Rattus norvegicus (rat)-Rattus norvegicus (Rat))	BDBM50227299 (CHEMBL149187) Show SMILES CCOC(C)COC1CCN(CC1)c1nc(N)c2cc(OC)c(OC)cc2n1 Show InChI InChI=1S/C20H30N4O4/c1-5-27-13(2)12-28-14-6-8-24(9-7-14)20-22-16-11-18(26-4)17(25-3)10-15(16)19(21)23-20/h10-11,13-14H,5-9,12H2,1-4H3,(H2,21,22,23)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	0.990	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Binding affinity for alpha-1 adrenergic receptor by displacement of [3H]-prazosin from rat brain homogenate preparation				J Med Chem 31: 516-20 (1988) BindingDB Entry DOI: 10.7270/Q2ZP48BH
					More data for this Ligand-Target Pair

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