Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14046 (Aminofurazanyl-azabenzimidazole 6m | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14044 (Aminofurazanyl-azabenzimidazole 6k | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14042 (Aminofurazanyl-azabenzimidazole 6i | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14043 (Aminofurazanyl-azabenzimidazole 6j | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14045 (Aminofurazanyl-azabenzimidazole 6l | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14035 (Aminofurazanyl-azabenzimidazole 6c | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14047 (Aminofurazanyl-azabenzimidazole 6n | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase MCE PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 1.80 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14041 (Aminofurazanyl-azabenzimidazole 6h | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 2 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14040 (Aminofurazanyl-azabenzimidazole 6g | N-(3-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14033 (4-{1-ethyl-6-methoxy-1H-imidazo[4,5-c]pyridin-2-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 4.40 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14037 (1-(3-{[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 13 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14039 (4-[6-(3-aminophenoxy)-1-ethyl-1H-imidazo[4,5-c]pyr...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 18 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14032 (4-(1-ethyl-1H-imidazo[4,5-c]pyridin-2-yl)-1,2,5-ox...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 19 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14034 (4-{1-ethyl-6-phenoxy-1H-imidazo[4,5-c]pyridin-2-yl...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 30 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14038 (4-[1-ethyl-6-(3-methanesulfonylphenoxy)-1H-imidazo...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 33 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Rho-associated protein kinase 1 (Homo sapiens (Human)) | BDBM14036 (Aminofurazanyl-azabenzimidazole 6d | N-(4-{[2-(4-a...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | Article PubMed | n/a | n/a | 90 | n/a | n/a | n/a | n/a | 7.4 | 22 |
GlaxoSmithKline | Assay Description The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid... | J Med Chem 50: 2-5 (2007) Article DOI: 10.1021/jm060873p BindingDB Entry DOI: 10.7270/Q2F18WZB | |||||||||||
More data for this Ligand-Target Pair |