Found 132 hits with Last Name = 'cottin' and Initial = 't' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Aurora kinase A
(Homo sapiens (Human)) | BDBM84651
(TC-107)Show InChI InChI=1S/C17H14FN3O/c18-13-4-1-5-14(10-13)21-17-15-9-12(3-2-8-22)6-7-16(15)19-11-20-17/h1-7,9-11,22H,8H2,(H,19,20,21) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Parc de Recerca Biomedica de Barcelona
| Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur... |
Chembiochem 10: 464-78 (2009)
Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300863
(CHEMBL568011 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES COc1cc(cc(OC)c1OC)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C23H20ClN3O4/c1-29-19-10-13(11-20(30-2)21(19)31-3)23(28)25-14-8-9-16(24)15(12-14)22-26-17-6-4-5-7-18(17)27-22/h4-12H,1-3H3,(H,25,28)(H,26,27) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 79.8 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50249489
(CHEMBL514344 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES CCOc1cc(cc(OCC)c1OCC)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C26H26ClN3O4/c1-4-32-22-13-16(14-23(33-5-2)24(22)34-6-3)26(31)28-17-11-12-19(27)18(15-17)25-29-20-9-7-8-10-21(20)30-25/h7-15H,4-6H2,1-3H3,(H,28,31)(H,29,30) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 97.9 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300862
(CHEMBL577049 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES COc1ccc(cc1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C21H16ClN3O2/c1-27-15-9-6-13(7-10-15)21(26)23-14-8-11-17(22)16(12-14)20-24-18-4-2-3-5-19(18)25-20/h2-12H,1H3,(H,23,26)(H,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 117 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300861
(CHEMBL567378 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES FC(F)(F)c1cccc(c1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C21H13ClF3N3O/c22-16-9-8-14(11-15(16)19-27-17-6-1-2-7-18(17)28-19)26-20(29)12-4-3-5-13(10-12)21(23,24)25/h1-11H,(H,26,29)(H,27,28) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 119 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300860
(CHEMBL579397 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES Clc1ccc(NC(=O)c2ccccc2)cc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C20H14ClN3O/c21-16-11-10-14(22-20(25)13-6-2-1-3-7-13)12-15(16)19-23-17-8-4-5-9-18(17)24-19/h1-12H,(H,22,25)(H,23,24) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 163 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300859
(CHEMBL568022 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES Clc1ccc(NC(=O)c2ccc(cc2)C#N)cc1-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C21H13ClN4O/c22-17-10-9-15(24-21(27)14-7-5-13(12-23)6-8-14)11-16(17)20-25-18-3-1-2-4-19(18)26-20/h1-11H,(H,24,27)(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 185 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300858
(CHEMBL584688 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES CN(C)c1ccc(cc1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C22H19ClN4O/c1-27(2)16-10-7-14(8-11-16)22(28)24-15-9-12-18(23)17(13-15)21-25-19-5-3-4-6-20(19)26-21/h3-13H,1-2H3,(H,24,28)(H,25,26) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300857
(CHEMBL565554 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES Clc1ccc(cc1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C20H13Cl2N3O/c21-13-7-5-12(6-8-13)20(26)23-14-9-10-16(22)15(11-14)19-24-17-3-1-2-4-18(17)25-19/h1-11H,(H,23,26)(H,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 224 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300856
(CHEMBL583230 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES Fc1ccc(cc1)C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C20H13ClFN3O/c21-16-10-9-14(23-20(26)12-5-7-13(22)8-6-12)11-15(16)19-24-17-3-1-2-4-18(17)25-19/h1-11H,(H,23,26)(H,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 251 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300855
(CHEMBL578143 | N-(3-(1H-Benzo[d]imidazol-2-yl)-4-c...)Show SMILES COc1ccccc1C(=O)Nc1ccc(Cl)c(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C21H16ClN3O2/c1-27-19-9-5-2-6-14(19)21(26)23-13-10-11-16(22)15(12-13)20-24-17-7-3-4-8-18(17)25-20/h2-12H,1H3,(H,23,26)(H,24,25) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 876 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of IGF1R after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 930 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316781
(4-(2-(3-Amino-9-(5-(4-methoxyphenyl)pentyl)-2,3,4,...)Show SMILES COc1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1 Show InChI InChI=1S/C32H38N2O3/c1-36-27-13-8-23(9-14-27)5-3-2-4-19-34-31-16-10-25(33)21-29(31)30-22-28(15-17-32(30)34)37-20-18-24-6-11-26(35)12-7-24/h6-9,11-15,17,22,25,35H,2-5,10,16,18-21,33H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 940 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50316775
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1 Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 960 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316779
(2-{5-(4-Methoxyphenethoxy)-1-{5-[4-(methylthio)-ph...)Show SMILES COc1ccc(CCOc2ccc3n(CCCCCc4ccc(SC)cc4)cc(CCN)c3c2)cc1 Show InChI InChI=1S/C31H38N2O2S/c1-34-27-11-7-25(8-12-27)18-21-35-28-13-16-31-30(22-28)26(17-19-32)23-33(31)20-5-3-4-6-24-9-14-29(36-2)15-10-24/h7-16,22-23H,3-6,17-21,32H2,1-2H3 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 980 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 990 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of EGFR after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316775
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1 Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.01E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.02E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.04E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.06E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of IGF1R after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.07E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.09E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of EGFR after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.11E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.12E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of EGFR after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316776
(2-[5-(4-Hydroxyphenethoxy)-1-(4-phenyl)benzyl-1Hin...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2ccccc2)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C31H30N2O2/c32-18-16-27-22-33(21-24-6-10-26(11-7-24)25-4-2-1-3-5-25)31-15-14-29(20-30(27)31)35-19-17-23-8-12-28(34)13-9-23/h1-15,20,22,34H,16-19,21,32H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.17E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316788
(4-(2-(3-amino-9-(5-phenylpentyl)-2,3,4,4a,9,9a-hex...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCCCc1ccccc1 Show InChI InChI=1S/C31H36N2O2/c32-25-12-16-30-28(21-25)29-22-27(35-20-18-24-10-13-26(34)14-11-24)15-17-31(29)33(30)19-6-2-5-9-23-7-3-1-4-8-23/h1,3-4,7-8,10-11,13-15,17,22,25,34H,2,5-6,9,12,16,18-21,32H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316791
(2-{5-(4-Hydroxyphenethoxy)-1-{5-[4-(methylthio)-ph...)Show SMILES CSc1ccc(CCCCCn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1 Show InChI InChI=1S/C30H36N2O2S/c1-35-28-13-8-23(9-14-28)5-3-2-4-19-32-22-25(16-18-31)29-21-27(12-15-30(29)32)34-20-17-24-6-10-26(33)11-7-24/h6-15,21-22,33H,2-5,16-20,31H2,1H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.22E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316775
(2-[5-(4-Hydroxyphenethoxy)-1-(4-methoxyphenyl)-ben...)Show SMILES COc1ccc(cc1)-c1ccc(Cn2cc(CCN)c3cc(OCCc4ccc(O)cc4)ccc23)cc1 Show InChI InChI=1S/C32H32N2O3/c1-36-29-12-8-26(9-13-29)25-6-2-24(3-7-25)21-34-22-27(16-18-33)31-20-30(14-15-32(31)34)37-19-17-23-4-10-28(35)11-5-23/h2-15,20,22,35H,16-19,21,33H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.25E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of EGFR after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316776
(2-[5-(4-Hydroxyphenethoxy)-1-(4-phenyl)benzyl-1Hin...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2ccccc2)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C31H30N2O2/c32-18-16-27-22-33(21-24-6-10-26(11-7-24)25-4-2-1-3-5-25)31-15-14-29(20-30(27)31)35-19-17-23-8-12-28(34)13-9-23/h1-15,20,22,34H,16-19,21,32H2 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of EGFR after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM50316779
(2-{5-(4-Methoxyphenethoxy)-1-{5-[4-(methylthio)-ph...)Show SMILES COc1ccc(CCOc2ccc3n(CCCCCc4ccc(SC)cc4)cc(CCN)c3c2)cc1 Show InChI InChI=1S/C31H38N2O2S/c1-34-27-11-7-25(8-12-27)18-21-35-28-13-16-31-30(22-28)26(17-19-32)23-33(31)20-5-3-4-6-24-9-14-29(36-2)15-10-24/h7-16,22-23H,3-6,17-21,32H2,1-2H3 | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of VEGFR3 after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50232973
(CHEMBL254129 | CYCLOPAMINE)Show SMILES C[C@@H]1[C@@H]2NC[C@@H](C)C[C@H]2O[C@]11CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC2=C1C |r,c:32,t:18| Show InChI InChI=1S/C27H41NO2/c1-15-11-24-25(28-14-15)17(3)27(30-24)10-8-20-21-6-5-18-12-19(29)7-9-26(18,4)23(21)13-22(20)16(27)2/h5,15,17,19-21,23-25,28-29H,6-14H2,1-4H3/t15-,17+,19-,20-,21-,23-,24+,25-,26-,27-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.31E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Sonic hedgehog protein
(Mus musculus (Mouse)) | BDBM50300854
(CHEMBL583231 | N-(3-(1H-Benzo[d]imidazol-2-yl)phen...)Show SMILES CCOc1cc(cc(OCC)c1OCC)C(=O)Nc1cccc(c1)-c1nc2ccccc2[nH]1 Show InChI InChI=1S/C26H27N3O4/c1-4-31-22-15-18(16-23(32-5-2)24(22)33-6-3)26(30)27-19-11-9-10-17(14-19)25-28-20-12-7-8-13-21(20)29-25/h7-16H,4-6H2,1-3H3,(H,27,30)(H,28,29) | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Leipzig
Curated by ChEMBL
| Assay Description Inhibition of SHH in mouse Shh-Light2 cells after 48 hrs by Gli1 reporter gene assay in presence of SAG |
Bioorg Med Chem 17: 4943-54 (2009)
Article DOI: 10.1016/j.bmc.2009.06.008 BindingDB Entry DOI: 10.7270/Q2SJ1KPN |
More data for this Ligand-Target Pair | |
Insulin-like growth factor 1 receptor
(Homo sapiens (Human)) | BDBM50316784
(4-(2-(3-Amino-9-(3-phenylpropyl)-2,3,4,9-tetrahydr...)Show SMILES NC1CCc2c(C1)c1cc(OCCc3ccc(O)cc3)ccc1n2CCCc1ccccc1 Show InChI InChI=1S/C29H32N2O2/c30-23-10-14-28-26(19-23)27-20-25(33-18-16-22-8-11-24(32)12-9-22)13-15-29(27)31(28)17-4-7-21-5-2-1-3-6-21/h1-3,5-6,8-9,11-13,15,20,23,32H,4,7,10,14,16-19,30H2 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.33E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of IGF1R after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Epidermal growth factor receptor
(Homo sapiens (Human)) | BDBM50316781
(4-(2-(3-Amino-9-(5-(4-methoxyphenyl)pentyl)-2,3,4,...)Show SMILES COc1ccc(CCCCCn2c3CCC(N)Cc3c3cc(OCCc4ccc(O)cc4)ccc23)cc1 Show InChI InChI=1S/C32H38N2O3/c1-36-27-13-8-23(9-14-27)5-3-2-4-19-34-31-16-10-25(33)21-29(31)30-22-28(15-17-32(30)34)37-20-18-24-6-11-26(35)12-7-24/h6-9,11-15,17,22,25,35H,2-5,10,16,18-21,33H2,1H3 | PDB MMDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.37E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of EGFR after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316779
(2-{5-(4-Methoxyphenethoxy)-1-{5-[4-(methylthio)-ph...)Show SMILES COc1ccc(CCOc2ccc3n(CCCCCc4ccc(SC)cc4)cc(CCN)c3c2)cc1 Show InChI InChI=1S/C31H38N2O2S/c1-34-27-11-7-25(8-12-27)18-21-35-28-13-16-31-30(22-28)26(17-19-32)23-33(31)20-5-3-4-6-24-9-14-29(36-2)15-10-24/h7-16,22-23H,3-6,17-21,32H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.45E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.48E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 50 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 250 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 3
(Homo sapiens (Human)) | BDBM84651
(TC-107)Show InChI InChI=1S/C17H14FN3O/c18-13-4-1-5-14(10-13)21-17-15-9-12(3-2-8-22)6-7-16(15)19-11-20-17/h1-7,9-11,22H,8H2,(H,19,20,21) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | 7.5 | 4 |
Parc de Recerca Biomedica de Barcelona
| Assay Description The IC50 for the different compounds was determined with Invitrogen Z'-LYTE kinase assay kit Ser/Thr 1 peptide PV3174 by following the manufactur... |
Chembiochem 10: 464-78 (2009)
Article DOI: 10.1002/cbic.200800600 BindingDB Entry DOI: 10.7270/Q24F1P8K |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50316792
(2-{5-(4-Hydroxyphenethoxy)-1-[4-(3-trifluoromethyl...)Show SMILES NCCc1cn(Cc2ccc(cc2)-c2cccc(c2)C(F)(F)F)c2ccc(OCCc3ccc(O)cc3)cc12 Show InChI InChI=1S/C32H29F3N2O2/c33-32(34,35)27-3-1-2-25(18-27)24-8-4-23(5-9-24)20-37-21-26(14-16-36)30-19-29(12-13-31(30)37)39-17-15-22-6-10-28(38)11-7-22/h1-13,18-19,21,38H,14-17,20,36H2 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£t Leipzig
Curated by ChEMBL
| Assay Description Noncompetitive inhibition of VEGFR2 after 30 mins by chemiluminescence ELISA in presence of 25 uM ATP |
Bioorg Med Chem 18: 3387-402 (2010)
Article DOI: 10.1016/j.bmc.2010.04.001 BindingDB Entry DOI: 10.7270/Q21836NT |
More data for this Ligand-Target Pair | |