Found 9 hits with Last Name = 'ferri' and Initial = 'n' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Ras-related C3 botulinum toxin substrate 1
(Homo sapiens (Human)) | BDBM50007190
(CHEMBL3237589)Show SMILES CCn1c2ccccc2c2cc(Nc3ccnc(NCCCN4CCOCC4)n3)ccc12 Show InChI InChI=1S/C25H30N6O/c1-2-31-22-7-4-3-6-20(22)21-18-19(8-9-23(21)31)28-24-10-12-27-25(29-24)26-11-5-13-30-14-16-32-17-15-30/h3-4,6-10,12,18H,2,5,11,13-17H2,1H3,(H2,26,27,28,29) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assay |
J Med Chem 57: 2953-62 (2014)
Article DOI: 10.1021/jm401924s BindingDB Entry DOI: 10.7270/Q2D2204K |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50497171
(CHEMBL3286844)Show SMILES CSCC[C@H](NC(=O)c1ccc(NC(=O)Cc2csc(N)n2)cc1-c1ccoc1)C(O)=O |r| Show InChI InChI=1S/C21H22N4O5S2/c1-31-7-5-17(20(28)29)25-19(27)15-3-2-13(8-16(15)12-4-6-30-10-12)23-18(26)9-14-11-32-21(22)24-14/h2-4,6,8,10-11,17H,5,7,9H2,1H3,(H2,22,24)(H,23,26)(H,25,27)(H,28,29)/t17-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of recombinant FTase (unknown origin) by spectrofluorimetric analysis |
Bioorg Med Chem Lett 24: 2924-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.078 BindingDB Entry DOI: 10.7270/Q2K35XM2 |
More data for this Ligand-Target Pair | |
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
(Homo sapiens (Human)) | BDBM50497172
(CHEMBL3286836)Show SMILES CSCC[C@H](NC(=O)c1ccc(OCC2COc3ccccc3O2)cc1-c1ccsc1)C(O)=O |r| Show InChI InChI=1S/C25H25NO6S2/c1-33-10-9-21(25(28)29)26-24(27)19-7-6-17(12-20(19)16-8-11-34-15-16)30-13-18-14-31-22-4-2-3-5-23(22)32-18/h2-8,11-12,15,18,21H,9-10,13-14H2,1H3,(H,26,27)(H,28,29)/t18?,21-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ di Milano
Curated by ChEMBL
| Assay Description Inhibition of recombinant FTase (unknown origin) by spectrofluorimetric analysis |
Bioorg Med Chem Lett 24: 2924-7 (2014)
Article DOI: 10.1016/j.bmcl.2014.04.078 BindingDB Entry DOI: 10.7270/Q2K35XM2 |
More data for this Ligand-Target Pair | |
Ras-related C3 botulinum toxin substrate 1
(Homo sapiens (Human)) | BDBM50293841
(3-((3,5-dimethylisoxazol-4-yl)methoxy)-N-(4-methyl...)Show SMILES Cc1noc(C)c1COc1cccc(c1)C(=O)Nc1ccc(C)c(c1)S(C)(=O)=O Show InChI InChI=1S/C21H22N2O5S/c1-13-8-9-17(11-20(13)29(4,25)26)22-21(24)16-6-5-7-18(10-16)27-12-19-14(2)23-28-15(19)3/h5-11H,12H2,1-4H3,(H,22,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.22E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA |
J Med Chem 52: 4087-90 (2009)
Article DOI: 10.1021/jm8015987 BindingDB Entry DOI: 10.7270/Q23T9H81 |
More data for this Ligand-Target Pair | |
Ras-related C3 botulinum toxin substrate 1
(Homo sapiens (Human)) | BDBM50293840
(CHEMBL562095 | N-(4-methoxy-3-(piperidin-1-ylsulfo...)Show SMILES COc1ccc(NC(=O)c2n[nH]c3ccccc23)cc1S(=O)(=O)N1CCCCC1 Show InChI InChI=1S/C20H22N4O4S/c1-28-17-10-9-14(13-18(17)29(26,27)24-11-5-2-6-12-24)21-20(25)19-15-7-3-4-8-16(15)22-23-19/h3-4,7-10,13H,2,5-6,11-12H2,1H3,(H,21,25)(H,22,23) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 2.41E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA |
J Med Chem 52: 4087-90 (2009)
Article DOI: 10.1021/jm8015987 BindingDB Entry DOI: 10.7270/Q23T9H81 |
More data for this Ligand-Target Pair | |
Ras-related C3 botulinum toxin substrate 1
(Homo sapiens (Human)) | BDBM50293842
(1-(4-morpholinophenylamino)-1-oxopropan-2-yl 1-hyd...)Show SMILES CC(OC(=O)c1ccc2ccccc2c1O)C(=O)Nc1ccc(cc1)N1CCOCC1 Show InChI InChI=1S/C24H24N2O5/c1-16(31-24(29)21-11-6-17-4-2-3-5-20(17)22(21)27)23(28)25-18-7-9-19(10-8-18)26-12-14-30-15-13-26/h2-11,16,27H,12-15H2,1H3,(H,25,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.83E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA |
J Med Chem 52: 4087-90 (2009)
Article DOI: 10.1021/jm8015987 BindingDB Entry DOI: 10.7270/Q23T9H81 |
More data for this Ligand-Target Pair | |
Ras-related C3 botulinum toxin substrate 1
(Homo sapiens (Human)) | BDBM50293843
(1,8-diamino-6-methoxy-3-(4-(2-methoxyphenyl)pipera...)Show SMILES COc1cc2c(C#N)c(nc(N)c2c(N)n1)N1CCN(CC1)c1ccccc1OC Show InChI InChI=1S/C21H23N7O2/c1-29-16-6-4-3-5-15(16)27-7-9-28(10-8-27)21-14(12-22)13-11-17(30-2)25-19(23)18(13)20(24)26-21/h3-6,11H,7-10H2,1-2H3,(H2,23,25)(H2,24,26) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 4.61E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA |
J Med Chem 52: 4087-90 (2009)
Article DOI: 10.1021/jm8015987 BindingDB Entry DOI: 10.7270/Q23T9H81 |
More data for this Ligand-Target Pair | |
Ras-related C3 botulinum toxin substrate 1
(Homo sapiens (Human)) | BDBM50293839
(2-(4-fluoro-3-nitrophenylamino)-N-(4-morpholinophe...)Show SMILES [O-][N+](=O)c1cc(NCC(=O)Nc2ccc(cc2)N2CCOCC2)ccc1F Show InChI InChI=1S/C18H19FN4O4/c19-16-6-3-14(11-17(16)23(25)26)20-12-18(24)21-13-1-4-15(5-2-13)22-7-9-27-10-8-22/h1-6,11,20H,7-10,12H2,(H,21,24) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 5.72E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Inhibition of PDGF-BB-stimulated Rac1 activity in human aortic smooth muscle cells assessed as reduction of Rac1GTP level after 4 hrs by G-LISA |
J Med Chem 52: 4087-90 (2009)
Article DOI: 10.1021/jm8015987 BindingDB Entry DOI: 10.7270/Q23T9H81 |
More data for this Ligand-Target Pair | |
Ras-related C3 botulinum toxin substrate 1
(Homo sapiens (Human)) | BDBM50007189
(CHEMBL3237582)Show SMILES CC(CCCN(C)C)Nc1nc(C)cc(Nc2ccc3nc(C)cc(N)c3c2)n1 Show InChI InChI=1S/C22H31N7/c1-14(7-6-10-29(4)5)25-22-26-16(3)12-21(28-22)27-17-8-9-20-18(13-17)19(23)11-15(2)24-20/h8-9,11-14H,6-7,10H2,1-5H3,(H2,23,24)(H2,25,26,27,28) | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| CHEMBL PC cid PC sid UniChem
Similars
| Article PubMed
| n/a | n/a | 9.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Universit£ degli Studi di Milano
Curated by ChEMBL
| Assay Description Inhibition of Rac1 in human MDA-MB-435 cells after 24 hrs by G-LISA assay |
J Med Chem 57: 2953-62 (2014)
Article DOI: 10.1021/jm401924s BindingDB Entry DOI: 10.7270/Q2D2204K |
More data for this Ligand-Target Pair | |