Found 45 hits with Last Name = 'hickin' and Initial = 'hg' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216485
(5-benzyl-6-(4-(3-chlorophenyl)piperidin-1-yl)pyrim...)Show SMILES Clc1cccc(c1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-4-7-17(14-18)16-9-11-26(12-10-16)20-19(21(27)25-22(28)24-20)13-15-5-2-1-3-6-15/h1-8,14,16H,9-13H2,(H2,24,25,27,28) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 4.90 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216493
(5-benzyl-6-(3-phenylpiperidin-1-yl)pyrimidine-2,4(...)Show SMILES O=c1[nH]c(N2CCCC(C2)c2ccccc2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C22H23N3O2/c26-21-19(14-16-8-3-1-4-9-16)20(23-22(27)24-21)25-13-7-12-18(15-25)17-10-5-2-6-11-17/h1-6,8-11,18H,7,12-15H2,(H2,23,24,26,27) | PDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 6.5 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216480
(5-benzyl-6-(4-(2-methoxyphenyl)piperidin-1-yl)pyri...)Show SMILES COc1ccccc1C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C23H25N3O3/c1-29-20-10-6-5-9-18(20)17-11-13-26(14-12-17)21-19(22(27)25-23(28)24-21)15-16-7-3-2-4-8-16/h2-10,17H,11-15H2,1H3,(H2,24,25,27,28) | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 7.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216491
(5-benzyl-6-(4-phenylpiperidin-1-yl)pyrimidine-2,4(...)Show SMILES O=c1[nH]c(N2CCC(CC2)c2ccccc2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C22H23N3O2/c26-21-19(15-16-7-3-1-4-8-16)20(23-22(27)24-21)25-13-11-18(12-14-25)17-9-5-2-6-10-17/h1-10,18H,11-15H2,(H2,23,24,26,27) | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 8.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216488
(5-(2-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1ccccc1Cc1c([nH]c(=O)[nH]c1=O)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H22ClN3O2/c23-19-9-5-4-8-17(19)14-18-20(24-22(28)25-21(18)27)26-12-10-16(11-13-26)15-6-2-1-3-7-15/h1-9,16H,10-14H2,(H2,24,25,27,28) | PDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 8.70 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216474
(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1cccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)c1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-4-5-15(13-18)14-19-20(24-22(28)25-21(19)27)26-11-9-17(10-12-26)16-6-2-1-3-7-16/h1-8,13,17H,9-12,14H2,(H2,24,25,27,28) | PDB
KEGG
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antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 9.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216479
(5-benzyl-6-(4-(3-methoxyphenyl)piperidin-1-yl)pyri...)Show SMILES COc1cccc(c1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C23H25N3O3/c1-29-19-9-5-8-18(15-19)17-10-12-26(13-11-17)21-20(22(27)25-23(28)24-21)14-16-6-3-2-4-7-16/h2-9,15,17H,10-14H2,1H3,(H2,24,25,27,28) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 9.20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216494
(5-(3-bromobenzyl)-6-(4-phenylpiperidin-1-yl)pyrimi...)Show SMILES Brc1cccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)c1 Show InChI InChI=1S/C22H22BrN3O2/c23-18-8-4-5-15(13-18)14-19-20(24-22(28)25-21(19)27)26-11-9-17(10-12-26)16-6-2-1-3-7-16/h1-8,13,17H,9-12,14H2,(H2,24,25,27,28) | PDB
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GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 14 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216476
(5-(3-chlorobenzyl)-6-(4-benzylpiperidin-1-yl)-3-me...)Show SMILES Cn1c(=O)[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H26ClN3O2/c1-27-23(29)21(16-19-8-5-9-20(25)15-19)22(26-24(27)30)28-12-10-18(11-13-28)14-17-6-3-2-4-7-17/h2-9,15,18H,10-14,16H2,1H3,(H,26,30) | PDB
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antibodypedia
GoogleScholar
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 16 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216482
(5-benzyl-6-(4-benzylpiperidin-1-yl)pyrimidine-2,4(...)Show SMILES O=c1[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C23H25N3O2/c27-22-20(16-18-9-5-2-6-10-18)21(24-23(28)25-22)26-13-11-19(12-14-26)15-17-7-3-1-4-8-17/h1-10,19H,11-16H2,(H2,24,25,27,28) | PDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 19 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216489
(5-benzyl-3-methyl-6-(4-phenylpiperidin-1-yl)pyrimi...)Show SMILES Cn1c(=O)[nH]c(N2CCC(CC2)c2ccccc2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C23H25N3O2/c1-25-22(27)20(16-17-8-4-2-5-9-17)21(24-23(25)28)26-14-12-19(13-15-26)18-10-6-3-7-11-18/h2-11,19H,12-16H2,1H3,(H,24,28) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 20 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216473
(5-benzyl-6-(4-benzylpiperidin-1-yl)-3-methylpyrimi...)Show SMILES Cn1c(=O)[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C24H27N3O2/c1-26-23(28)21(17-19-10-6-3-7-11-19)22(25-24(26)29)27-14-12-20(13-15-27)16-18-8-4-2-5-9-18/h2-11,20H,12-17H2,1H3,(H,25,29) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 24 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216478
(5-(4-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1ccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)cc1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-6-15(7-9-18)14-19-20(24-22(28)25-21(19)27)26-12-10-17(11-13-26)16-4-2-1-3-5-16/h1-9,17H,10-14H2,(H2,24,25,27,28) | PDB
KEGG
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GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 31 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216477
(5-(2-bromobenzyl)-6-(4-benzylpiperidin-1-yl)-3-met...)Show SMILES Cn1c(=O)[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2ccccc2Br)c1=O Show InChI InChI=1S/C24H26BrN3O2/c1-27-23(29)20(16-19-9-5-6-10-21(19)25)22(26-24(27)30)28-13-11-18(12-14-28)15-17-7-3-2-4-8-17/h2-10,18H,11-16H2,1H3,(H,26,30) | PDB
KEGG
UniProtKB/SwissProt
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 33 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216495
(3-((2,4-dioxo-6-(4-phenylpiperidin-1-yl)-1,2,3,4-t...)Show SMILES O=c1[nH]c(N2CCC(CC2)c2ccccc2)c(Cc2cccc(c2)C#N)c(=O)[nH]1 Show InChI InChI=1S/C23H22N4O2/c24-15-17-6-4-5-16(13-17)14-20-21(25-23(29)26-22(20)28)27-11-9-19(10-12-27)18-7-2-1-3-8-18/h1-8,13,19H,9-12,14H2,(H2,25,26,28,29) | PDB
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 37 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216492
(5-benzyl-6-(4-(4-methoxyphenyl)piperidin-1-yl)pyri...)Show SMILES COc1ccc(cc1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C23H25N3O3/c1-29-19-9-7-17(8-10-19)18-11-13-26(14-12-18)21-20(22(27)25-23(28)24-21)15-16-5-3-2-4-6-16/h2-10,18H,11-15H2,1H3,(H2,24,25,27,28) | PDB
KEGG
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| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 45 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216490
(CHEMBL231500 | N-(4-(1-(5-benzyl-2,6-dioxo-1,2,3,6...)Show SMILES CC(=O)Nc1ccc(cc1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C24H26N4O3/c1-16(29)25-20-9-7-18(8-10-20)19-11-13-28(14-12-19)22-21(23(30)27-24(31)26-22)15-17-5-3-2-4-6-17/h2-10,19H,11-15H2,1H3,(H,25,29)(H2,26,27,30,31) | PDB
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AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
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| Article
PubMed
| 46 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216483
(5-benzyl-6-(3-phenylpyrrolidin-1-yl)pyrimidine-2,4...)Show SMILES O=c1[nH]c(N2CCC(C2)c2ccccc2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C21H21N3O2/c25-20-18(13-15-7-3-1-4-8-15)19(22-21(26)23-20)24-12-11-17(14-24)16-9-5-2-6-10-16/h1-10,17H,11-14H2,(H2,22,23,25,26) | PDB
KEGG
UniProtKB/SwissProt
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DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| 47 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216488
(5-(2-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1ccccc1Cc1c([nH]c(=O)[nH]c1=O)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H22ClN3O2/c23-19-9-5-4-8-17(19)14-18-20(24-22(28)25-21(18)27)26-12-10-16(11-13-26)15-6-2-1-3-7-15/h1-9,16H,10-14H2,(H2,24,25,27,28) | PDB
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| 50 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216494
(5-(3-bromobenzyl)-6-(4-phenylpiperidin-1-yl)pyrimi...)Show SMILES Brc1cccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)c1 Show InChI InChI=1S/C22H22BrN3O2/c23-18-8-4-5-15(13-18)14-19-20(24-22(28)25-21(19)27)26-11-9-17(10-12-26)16-6-2-1-3-7-16/h1-8,13,17H,9-12,14H2,(H2,24,25,27,28) | PDB
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| 65 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216481
(5-benzyl-3-methyl-6-(4-phenoxypiperidin-1-yl)pyrim...)Show SMILES Cn1c(=O)[nH]c(N2CCC(CC2)Oc2ccccc2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C23H25N3O3/c1-25-22(27)20(16-17-8-4-2-5-9-17)21(24-23(25)28)26-14-12-19(13-15-26)29-18-10-6-3-7-11-18/h2-11,19H,12-16H2,1H3,(H,24,28) | PDB
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| 78 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216491
(5-benzyl-6-(4-phenylpiperidin-1-yl)pyrimidine-2,4(...)Show SMILES O=c1[nH]c(N2CCC(CC2)c2ccccc2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C22H23N3O2/c26-21-19(15-16-7-3-1-4-8-16)20(23-22(27)24-21)25-13-11-18(12-14-25)17-9-5-2-6-10-17/h1-10,18H,11-15H2,(H2,23,24,26,27) | PDB
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| 93 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216474
(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1cccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)c1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-4-5-15(13-18)14-19-20(24-22(28)25-21(19)27)26-11-9-17(10-12-26)16-6-2-1-3-7-16/h1-8,13,17H,9-12,14H2,(H2,24,25,27,28) | PDB
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| 96 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216485
(5-benzyl-6-(4-(3-chlorophenyl)piperidin-1-yl)pyrim...)Show SMILES Clc1cccc(c1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-4-7-17(14-18)16-9-11-26(12-10-16)20-19(21(27)25-22(28)24-20)13-15-5-2-1-3-6-15/h1-8,14,16H,9-13H2,(H2,24,25,27,28) | PDB
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| 97 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216473
(5-benzyl-6-(4-benzylpiperidin-1-yl)-3-methylpyrimi...)Show SMILES Cn1c(=O)[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C24H27N3O2/c1-26-23(28)21(17-19-10-6-3-7-11-19)22(25-24(26)29)27-14-12-20(13-15-27)16-18-8-4-2-5-9-18/h2-11,20H,12-17H2,1H3,(H,25,29) | PDB
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| 100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216497
(5-benzyl-6-(4-(4-chlorophenyl)piperidin-1-yl)pyrim...)Show SMILES Clc1ccc(cc1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-6-16(7-9-18)17-10-12-26(13-11-17)20-19(21(27)25-22(28)24-20)14-15-4-2-1-3-5-15/h1-9,17H,10-14H2,(H2,24,25,27,28) | PDB
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| 103 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216476
(5-(3-chlorobenzyl)-6-(4-benzylpiperidin-1-yl)-3-me...)Show SMILES Cn1c(=O)[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2cccc(Cl)c2)c1=O Show InChI InChI=1S/C24H26ClN3O2/c1-27-23(29)21(16-19-8-5-9-20(25)15-19)22(26-24(27)30)28-12-10-18(11-13-28)14-17-6-3-2-4-7-17/h2-9,15,18H,10-14,16H2,1H3,(H,26,30) | PDB
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| 135 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216482
(5-benzyl-6-(4-benzylpiperidin-1-yl)pyrimidine-2,4(...)Show SMILES O=c1[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C23H25N3O2/c27-22-20(16-18-9-5-2-6-10-18)21(24-23(28)25-22)26-13-11-19(12-14-26)15-17-7-3-1-4-8-17/h1-10,19H,11-16H2,(H2,24,25,27,28) | PDB
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| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216496
(5-benzyl-3-methyl-6-(4-phenethylpiperidin-1-yl)pyr...)Show SMILES Cn1c(=O)[nH]c(N2CCC(CCc3ccccc3)CC2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C25H29N3O2/c1-27-24(29)22(18-21-10-6-3-7-11-21)23(26-25(27)30)28-16-14-20(15-17-28)13-12-19-8-4-2-5-9-19/h2-11,20H,12-18H2,1H3,(H,26,30) | PDB
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| 154 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216479
(5-benzyl-6-(4-(3-methoxyphenyl)piperidin-1-yl)pyri...)Show SMILES COc1cccc(c1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C23H25N3O3/c1-29-19-9-5-8-18(15-19)17-10-12-26(13-11-17)21-20(22(27)25-23(28)24-21)14-16-6-3-2-4-7-16/h2-9,15,17H,10-14H2,1H3,(H2,24,25,27,28) | PDB
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| 158 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216489
(5-benzyl-3-methyl-6-(4-phenylpiperidin-1-yl)pyrimi...)Show SMILES Cn1c(=O)[nH]c(N2CCC(CC2)c2ccccc2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C23H25N3O2/c1-25-22(27)20(16-17-8-4-2-5-9-17)21(24-23(25)28)26-14-12-19(13-15-26)18-10-6-3-7-11-18/h2-11,19H,12-16H2,1H3,(H,24,28) | PDB
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| 190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216493
(5-benzyl-6-(3-phenylpiperidin-1-yl)pyrimidine-2,4(...)Show SMILES O=c1[nH]c(N2CCCC(C2)c2ccccc2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C22H23N3O2/c26-21-19(14-16-8-3-1-4-9-16)20(23-22(27)24-21)25-13-7-12-18(15-25)17-10-5-2-6-11-17/h1-6,8-11,18H,7,12-15H2,(H2,23,24,26,27) | PDB
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| 225 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Activity at human GR expressed in SW1353 cells |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216487
(6-(4-benzoylpiperidin-1-yl)-5-benzyl-3-methylpyrim...)Show SMILES Cn1c(=O)[nH]c(N2CCC(CC2)C(=O)c2ccccc2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C24H25N3O3/c1-26-23(29)20(16-17-8-4-2-5-9-17)22(25-24(26)30)27-14-12-19(13-15-27)21(28)18-10-6-3-7-11-18/h2-11,19H,12-16H2,1H3,(H,25,30) | PDB
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| 227 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216478
(5-(4-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1ccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)cc1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-6-15(7-9-18)14-19-20(24-22(28)25-21(19)27)26-12-10-17(11-13-26)16-4-2-1-3-5-16/h1-9,17H,10-14H2,(H2,24,25,27,28) | PDB
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| 260 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50216480
(5-benzyl-6-(4-(2-methoxyphenyl)piperidin-1-yl)pyri...)Show SMILES COc1ccccc1C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C23H25N3O3/c1-29-20-10-6-5-9-18(20)17-11-13-26(14-12-17)21-19(22(27)25-23(28)24-21)15-16-7-3-2-4-8-16/h2-10,17H,11-15H2,1H3,(H2,24,25,27,28) | PDB
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| 298 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]aldosterone from mineralocorticoid receptor expressed in Sf9 cells |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216477
(5-(2-bromobenzyl)-6-(4-benzylpiperidin-1-yl)-3-met...)Show SMILES Cn1c(=O)[nH]c(N2CCC(Cc3ccccc3)CC2)c(Cc2ccccc2Br)c1=O Show InChI InChI=1S/C24H26BrN3O2/c1-27-23(29)20(16-19-9-5-6-10-21(19)25)22(26-24(27)30)28-13-11-18(12-14-28)15-17-7-3-2-4-8-17/h2-10,18H,11-16H2,1H3,(H,26,30) | PDB
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| 300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Antagonist activity at human GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216475
(5-benzyl-6-(4-benzyl-4-hydroxypiperidin-1-yl)-3-me...)Show SMILES Cn1c(=O)[nH]c(N2CCC(O)(Cc3ccccc3)CC2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C24H27N3O3/c1-26-22(28)20(16-18-8-4-2-5-9-18)21(25-23(26)29)27-14-12-24(30,13-15-27)17-19-10-6-3-7-11-19/h2-11,30H,12-17H2,1H3,(H,25,29) | PDB
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| 360 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216486
(5-benzyl-3-methyl-6-(4-phenylpiperazin-1-yl)pyrimi...)Show SMILES Cn1c(=O)[nH]c(N2CCN(CC2)c2ccccc2)c(Cc2ccccc2)c1=O Show InChI InChI=1S/C22H24N4O2/c1-24-21(27)19(16-17-8-4-2-5-9-17)20(23-22(24)28)26-14-12-25(13-15-26)18-10-6-3-7-11-18/h2-11H,12-16H2,1H3,(H,23,28) | PDB
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PC sid
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| Article
PubMed
| 470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50216485
(5-benzyl-6-(4-(3-chlorophenyl)piperidin-1-yl)pyrim...)Show SMILES Clc1cccc(c1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-4-7-17(14-18)16-9-11-26(12-10-16)20-19(21(27)25-22(28)24-20)13-15-5-2-1-3-6-15/h1-8,14,16H,9-13H2,(H2,24,25,27,28) | PDB
MMDB
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| CHEMBL
PC cid
PC sid
UniChem
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| Article
PubMed
| 527 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]aldosterone from mineralocorticoid receptor expressed in Sf9 cells |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50216474
(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1cccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)c1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-4-5-15(13-18)14-19-20(24-22(28)25-21(19)27)26-11-9-17(10-12-26)16-6-2-1-3-7-16/h1-8,13,17H,9-12,14H2,(H2,24,25,27,28) | PDB
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PC sid
UniChem
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| Article
PubMed
| 585 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]aldosterone from mineralocorticoid receptor expressed in Sf9 cells |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50216491
(5-benzyl-6-(4-phenylpiperidin-1-yl)pyrimidine-2,4(...)Show SMILES O=c1[nH]c(N2CCC(CC2)c2ccccc2)c(Cc2ccccc2)c(=O)[nH]1 Show InChI InChI=1S/C22H23N3O2/c26-21-19(15-16-7-3-1-4-8-16)20(23-22(27)24-21)25-13-11-18(12-14-25)17-9-5-2-6-10-17/h1-10,18H,11-15H2,(H2,23,24,26,27) | PDB
MMDB
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PC sid
UniChem
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| Article
PubMed
| 930 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]aldosterone from mineralocorticoid receptor expressed in Sf9 cells |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50216479
(5-benzyl-6-(4-(3-methoxyphenyl)piperidin-1-yl)pyri...)Show SMILES COc1cccc(c1)C1CCN(CC1)c1[nH]c(=O)[nH]c(=O)c1Cc1ccccc1 Show InChI InChI=1S/C23H25N3O3/c1-29-19-9-5-8-18(15-19)17-10-12-26(13-11-17)21-20(22(27)25-23(28)24-21)14-16-6-3-2-4-7-16/h2-9,15,17H,10-14H2,1H3,(H2,24,25,27,28) | PDB
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| Article
PubMed
| 1.27E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]aldosterone from mineralocorticoid receptor expressed in Sf9 cells |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Mineralocorticoid receptor
(Homo sapiens (Human)) | BDBM50216488
(5-(2-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1ccccc1Cc1c([nH]c(=O)[nH]c1=O)N1CCC(CC1)c1ccccc1 Show InChI InChI=1S/C22H22ClN3O2/c23-19-9-5-4-8-17(19)14-18-20(24-22(28)25-21(18)27)26-12-10-16(11-13-26)15-6-2-1-3-7-15/h1-9,16H,10-14H2,(H2,24,25,27,28) | PDB
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| CHEMBL
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PC sid
UniChem
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| Article
PubMed
| 3.49E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]aldosterone from mineralocorticoid receptor expressed in Sf9 cells |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Glucocorticoid receptor
(Homo sapiens (Human)) | BDBM50216484
(5-(3-(trifluoromethyl)benzyl)-6-(4-hydroxypiperidi...)Show SMILES Cn1c(=O)[nH]c(N2CCC(O)CC2)c(Cc2cccc(c2)C(F)(F)F)c1=O Show InChI InChI=1S/C18H20F3N3O3/c1-23-16(26)14(10-11-3-2-4-12(9-11)18(19,20)21)15(22-17(23)27)24-7-5-13(25)6-8-24/h2-4,9,13,25H,5-8,10H2,1H3,(H,22,27) | PDB
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PubMed
| 4.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]dexamethasone from human recombinant GR |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
Progesterone receptor
(Homo sapiens (Human)) | BDBM50216474
(5-(3-chlorobenzyl)-6-(4-phenylpiperidin-1-yl)pyrim...)Show SMILES Clc1cccc(Cc2c([nH]c(=O)[nH]c2=O)N2CCC(CC2)c2ccccc2)c1 Show InChI InChI=1S/C22H22ClN3O2/c23-18-8-4-5-15(13-18)14-19-20(24-22(28)25-21(19)27)26-11-9-17(10-12-26)16-6-2-1-3-7-16/h1-8,13,17H,9-12,14H2,(H2,24,25,27,28) | PDB
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UniChem
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PubMed
| 7.05E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Argenta Discovery Ltd
Curated by ChEMBL
| Assay Description
Displacement of [3H]progesterone from progesterone receptor |
Bioorg Med Chem Lett 17: 4901-5 (2007)
Article DOI: 10.1016/j.bmcl.2007.06.036
BindingDB Entry DOI: 10.7270/Q21Z444J |
More data for this
Ligand-Target Pair | |
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