BindingDB PrimarySearch

Found 38 hits with Last Name = 'horenstein' and Initial = 'na'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	1	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	41	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-Nicotine binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50099562 ((3aS,9bR)-1-Methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrr...) Show SMILES CN1CC[C@@H]2CCc3ccncc3[C@H]12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	400	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-Nicotine binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50099562 ((3aS,9bR)-1-Methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrr...) Show SMILES CN1CC[C@@H]2CCc3ccncc3[C@H]12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	590	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to alpha7 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50170269 ((2R,6S)-12-(cyanoboranyl)-3-methyl-3,12-diazatricy...) Show SMILES CN1CC[C@@H]2CCc3cc[n+](BC#N)cc3[C@H]12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	600	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-Nicotine binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50004108 ((+-)-nicotine \| (R,S)-nicotine \| (RS)-nicotine \| 3...) Show SMILES CN1CCCC1c1cccnc1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	770	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to alpha7 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50170269 ((2R,6S)-12-(cyanoboranyl)-3-methyl-3,12-diazatricy...) Show SMILES CN1CC[C@@H]2CCc3cc[n+](BC#N)cc3[C@H]12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	2.40E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to rat alpha7 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50099564 ((3aR,9bS)-1-Methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrr...) Show SMILES CN1CC[C@H]2CCc3ncccc3[C@@H]12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.22E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-Nicotine binding to alpha4-beta2 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	1.52E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to alpha7 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50170271 ((2S,6R)-10-(cyanoboranyl)-3-methyl-3,10-diazatricy...) Show SMILES CN1CC[C@H]2CCc3c(ccc[n+]3BC#N)[C@@H]12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to rat alpha7 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50170271 ((2S,6R)-10-(cyanoboranyl)-3-methyl-3,10-diazatricy...) Show SMILES CN1CC[C@H]2CCc3c(ccc[n+]3BC#N)[C@@H]12 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-Nicotine binding to rat alpha4-beta2 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50099564 ((3aR,9bS)-1-Methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrr...) Show SMILES CN1CC[C@H]2CCc3ncccc3[C@@H]12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Inhibition of [3H]-MLA binding to alpha7 nicotinic acetylcholine receptor of rat brain membrane				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241437 (CHEMBL4082927) Show SMILES CCN1CCN(CC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.15E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response admini...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50436919 (CHEMBL2402006) Show SMILES C1CCC(=NC1)c1cncc(c1)-c1ccccc1 \|c:3\| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Silent agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of PNU-120596-stimulated peak current				Bioorg Med Chem Lett 23: 4145-9 (2013) Article DOI: 10.1016/j.bmcl.2013.05.039 BindingDB Entry DOI: 10.7270/Q22V2HJ0
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Homo sapiens (Human))	BDBM50241432 (CHEMBL4061049) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.10E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha4beta2 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response a...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241434 (CHEMBL3747954) Show SMILES CC[N+]1(CC)CCN(CC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response admini...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241432 (CHEMBL4061049) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Antagonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of acetylcholine-induced current response admini...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50503425 (CHEMBL4448268) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<3.00E+4	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at -60 mV holding potential treated for 12 secs followed by compou...				Eur J Med Chem 160: 207-228 (2018) Article DOI: 10.1016/j.ejmech.2018.10.015 BindingDB Entry DOI: 10.7270/Q28K7DB2
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50503427 (CHEMBL4473595) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes measured at peak to net charge ratio at -60 mV holding potential treated f...				Eur J Med Chem 160: 207-228 (2018) Article DOI: 10.1016/j.ejmech.2018.10.015 BindingDB Entry DOI: 10.7270/Q28K7DB2
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50503428 (CHEMBL4437122) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<3.00E+4	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at -60 mV holding potential treated for 12 secs followed by compou...				Eur J Med Chem 160: 207-228 (2018) Article DOI: 10.1016/j.ejmech.2018.10.015 BindingDB Entry DOI: 10.7270/Q28K7DB2
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50503429 (CHEMBL4457159) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<3.00E+4	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at -60 mV holding potential treated for 12 secs followed by compou...				Eur J Med Chem 160: 207-228 (2018) Article DOI: 10.1016/j.ejmech.2018.10.015 BindingDB Entry DOI: 10.7270/Q28K7DB2
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50565550 (CHEMBL4777431) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	764	n/a	n/a	n/a	n/a
TBA					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at -60 mV holding potential by two electrode voltage-clamp assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112669 BindingDB Entry DOI: 10.7270/Q2TB1BNJ
TBA					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50503426 (CHEMBL4579933) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<3.00E+4	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at -60 mV holding potential treated for 12 secs followed by compou...				Eur J Med Chem 160: 207-228 (2018) Article DOI: 10.1016/j.ejmech.2018.10.015 BindingDB Entry DOI: 10.7270/Q28K7DB2
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50503425 (CHEMBL4448268) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	<3.00E+4	n/a	n/a	n/a	n/a
University of Milan Curated by ChEMBL					Assay Description Agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes measured at peak to net charge ratio at -60 mV holding potential treated f...				Eur J Med Chem 160: 207-228 (2018) Article DOI: 10.1016/j.ejmech.2018.10.015 BindingDB Entry DOI: 10.7270/Q28K7DB2
University of Milan Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241434 (CHEMBL3747954) Show SMILES CC[N+]1(CC)CCN(CC1)c1ccccc1 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.21E+5	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of maximum current response administered for...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50241432 (CHEMBL4061049) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as induction of maximum current response administered for...				J Med Chem 60: 7928-7934 (2017) Article DOI: 10.1021/acs.jmedchem.7b00875 BindingDB Entry DOI: 10.7270/Q20C4XX6
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50204416 (3-[1-(4-methoxy-phenyl)-meth-(E)-ylidene]-1-azonia...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.30E+3	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Agonist activity at nAChR alpha-7 expressed in Xenopus oocytes				Bioorg Med Chem Lett 17: 1520-2 (2007) Article DOI: 10.1016/j.bmcl.2007.01.003 BindingDB Entry DOI: 10.7270/Q2542PDZ
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50204415 (1-methyl-1-azonia-bicyclo[2.2.2]octane \| CHEMBL120...) Show SMILES C[N+]12CCC(CC1)CC2 Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	4.00E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Agonist activity at nAChR alpha-7 expressed in Xenopus oocytes				Bioorg Med Chem Lett 17: 1520-2 (2007) Article DOI: 10.1016/j.bmcl.2007.01.003 BindingDB Entry DOI: 10.7270/Q2542PDZ
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50204414 (3-[1-phenyl-meth-(E)-ylidene]-1-azonia-bicyclo[2.2...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+3	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Agonist activity at nAChR alpha-7 expressed in Xenopus oocytes				Bioorg Med Chem Lett 17: 1520-2 (2007) Article DOI: 10.1016/j.bmcl.2007.01.003 BindingDB Entry DOI: 10.7270/Q2542PDZ
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Homo sapiens (Human))	BDBM50565551 (CHEMBL4785409) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	322	n/a	n/a	n/a	n/a
TBA					Assay Description Partial agonist activity at human alpha7 nAChR expressed in Xenopus laevis oocytes at -60 mV holding potential by two electrode voltage-clamp assay				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112669 BindingDB Entry DOI: 10.7270/Q2TB1BNJ
TBA					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50170269 ((2R,6S)-12-(cyanoboranyl)-3-methyl-3,12-diazatricy...) Show SMILES CN1CC[C@@H]2CCc3cc[n+](BC#N)cc3[C@H]12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha7 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM82070 (CAS_29790-52-1 \| NICOTINE-L (BASE) \| Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 \|r\| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha4-beta2 nicotinic acetylcholinereceptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rattus norvegicus (Rat))	BDBM82070 (CAS_29790-52-1 \| NICOTINE-L (BASE) \| Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 \|r\| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	8.60E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha3-beta4 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.10E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha7 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-4/beta-2 (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.50E+5	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha4-beta2 nicotinic acetylcholinereceptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM50099562 ((3aS,9bR)-1-Methyl-2,3,3a,4,5,9b-hexahydro-1H-pyrr...) Show SMILES CN1CC[C@@H]2CCc3ccncc3[C@H]12 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	4.40E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha7 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-3/beta-4 (Rattus norvegicus (Rat))	BDBM50170270 (CHEMBL182530 \| S(-)nicotine-B) Show SMILES CN1CCC[C@H]1c1ccc[n+](BC#N)c1 Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	2.80E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha3-beta4 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat))	BDBM82070 (CAS_29790-52-1 \| NICOTINE-L (BASE) \| Nicotine-D sa...) Show SMILES CN1CCC[C@H]1c1cccnc1 \|r\| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase KEGG PC cid PC sid PDB UniChem Similars	PDB Article PubMed	n/a	n/a	n/a	n/a	1.30E+4	n/a	n/a	n/a	n/a
University of Florida Curated by ChEMBL					Assay Description Effective concentration against rat alpha7 nicotinic acetylcholine receptor				Bioorg Med Chem Lett 15: 3874-80 (2005) Article DOI: 10.1016/j.bmcl.2005.05.118 BindingDB Entry DOI: 10.7270/Q2ZK5G6J
University of Florida Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)